Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer.
Victoria A. Avanzato,Victoria A. Avanzato,M. Jeremiah Matson,M. Jeremiah Matson,Stephanie N. Seifert,Rhys Pryce,Brandi N. Williamson,Sarah L. Anzick,Kent D. Barbian,Seth D. Judson,Elizabeth R. Fischer,Craig Martens,Thomas A. Bowden,Emmie de Wit,Francis X. Riedo,Vincent J. Munster +15 more
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TLDR
The data indicate that certain immunocompromised patients may shed infectious virus for longer durations than previously recognized, and detection of subgenomic RNA is recommended in persistently SARS-CoV-2 positive individuals as a proxy for shedding of infectious virus.About:
This article is published in Cell.The article was published on 2020-12-23 and is currently open access. It has received 573 citations till now.read more
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Journal ArticleDOI
SARS-CoV-2 variants, spike mutations and immune escape.
William T. Harvey,Alessandro M Carabelli,Ben Jackson,Ravindra K. Gupta,E. Thomson,E. Thomson,Ewan M. Harrison,Ewan M. Harrison,Catherine Ludden,Richard Reeve,Andrew Rambaut,Sharon J. Peacock,David Robertson +12 more
TL;DR: A review of the literature on mutations of the SARS-CoV-2 spike protein, the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the protein structure is presented in this article.
Journal ArticleDOI
Detection of a SARS-CoV-2 variant of concern in South Africa.
Houriiyah Tegally,Eduan Wilkinson,Marta Giovanetti,Marta Giovanetti,Arash Iranzadeh,Vagner Fonseca,Vagner Fonseca,Jennifer Giandhari,Deelan Doolabh,Sureshnee Pillay,Emmanuel James San,Nokukhanya Msomi,Koleka Mlisana,Anne von Gottberg,Sibongile Walaza,Mushal Allam,Arshad Ismail,Thabo Mohale,Allison J. Glass,Susan Engelbrecht,Gert U. van Zyl,Wolfgang Preiser,Francesco Petruccione,Alex Sigal,Alex Sigal,Diana Hardie,Gert Marais,Nei yuan Hsiao,Stephen N.J. Korsman,Mary-Ann Davies,Lynn Tyers,Innocent Mudau,Denis York,Caroline Maslo,Dominique Goedhals,Shareef Abrahams,Oluwakemi Laguda-Akingba,Arghavan Alisoltani-Dehkordi,Arghavan Alisoltani-Dehkordi,Adam Godzik,Constantinos Kurt Wibmer,B.T. Sewell,José Lourenço,Luiz Carlos Junior Alcantara,Luiz Carlos Junior Alcantara,Sergei L Kosakovsky Pond,Steven Weaver,Darren P. Martin,Richard J Lessells,Richard J Lessells,Jinal N. Bhiman,Carolyn Williamson,Carolyn Williamson,Tulio de Oliveira,Tulio de Oliveira,Tulio de Oliveira +55 more
TL;DR: A newly arisen lineage of SARS-CoV-2 (designated 501Y.V2) was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province.
Journal ArticleDOI
Adaptive immunity to SARS-CoV-2 and COVID-19.
TL;DR: In this article, a picture has begun to emerge that reveals that CD4+ T cells, CD8+ Tcells, and neutralizing antibodies all contribute to control SARS-CoV-2 in both non-hospitalized and hospitalized cases of COVID-19.
Journal ArticleDOI
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil.
Nuno R. Faria,Thomas A. Mellan,Charles Whittaker,Ingra Morales Claro,Darlan da Silva Candido,Darlan da Silva Candido,Swapnil Mishra,Myuki A E Crispim,Flavia C. S. Sales,Iwona Hawryluk,John T. McCrone,Ruben J.G. Hulswit,Lucas A M Franco,Mariana S. Ramundo,Jaqueline Goes de Jesus,Pamela S Andrade,Thais M. Coletti,Giulia M. Ferreira,Camila A. M. Silva,Erika R. Manuli,Rafael Henrique Moraes Pereira,Pedro S. Peixoto,Moritz U. G. Kraemer,Nelson Gaburo,Cecilia da C. Camilo,Henrique Hoeltgebaum,William Marciel de Souza,Esmenia C. Rocha,Leandro Marques de Souza,Mariana C. Pinho,Leonardo José Tadeu de Araújo,Frederico S V Malta,Aline B. de Lima,Joice do P. Silva,Danielle A G Zauli,Alessandro C. S. Ferreira,Ricardo P Schnekenberg,Daniel J Laydon,Patrick G T Walker,Hannah M. Schlüter,Ana L. P. dos Santos,Maria S. Vidal,Valentina S. Del Caro,Rosinaldo M. F. Filho,Helem M. dos Santos,Renato Santana Aguiar,José Luiz Proença-Módena,Bruce Walker Nelson,James A. Hay,Melodie Monod,Xenia Miscouridou,Helen Coupland,Raphael Sonabend,Michaela A. C. Vollmer,Axel Gandy,Carlos A. Prete,Vitor H. Nascimento,Marc A. Suchard,Thomas A. Bowden,Sergei L Kosakovsky Pond,Chieh-Hsi Wu,Oliver Ratmann,Neil M. Ferguson,Christopher Dye,Nicholas J. Loman,Philippe Lemey,Andrew Rambaut,Nelson Abrahim Fraiji,Maria Perpétuo Socorro Sampaio Carvalho,Oliver G. Pybus,Oliver G. Pybus,Seth Flaxman,Samir Bhatt,Samir Bhatt,Ester Cerdeira Sabino +74 more
TL;DR: In this article, the authors used a two-category dynamical model that integrates genomic and mortality data to estimate that P.1 may be 1.7-to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection against infection with P.
Posted ContentDOI
Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa
Houriiyah Tegally,Eduan Wilkinson,Marta Giovanetti,Marta Giovanetti,Arash Iranzadeh,Vagner Fonseca,Vagner Fonseca,Jennifer Giandhari,Deelan Doolabh,Sureshnee Pillay,Emmanuel James San,Nokukhanya Msomi,Koleka Mlisana,Koleka Mlisana,Anne von Gottberg,Anne von Gottberg,Sibongile Walaza,Sibongile Walaza,Mushal Allam,Arshad Ismail,Thabo Mohale,Allison J. Glass,Susan Engelbrecht,Gert U. van Zyl,Wolfgang Preiser,Francesco Petruccione,Alex Sigal,Alex Sigal,Diana Hardie,Gert Marais,Marvin Hsiao,Stephen N.J. Korsman,Mary-Ann Davies,Lynn Tyers,Innocent Mudau,Denis York,Caroline Maslo,Dominique Goedhals,Shareef Abrahams,Oluwakemi Laguda-Akingba,Oluwakemi Laguda-Akingba,Arghavan Alisoltani-Dehkordi,Arghavan Alisoltani-Dehkordi,Adam Godzik,Constantinos Kurt Wibmer,B.T. Sewell,José Lourenço,Luiz Carlos Junior Alcantara,Luiz Carlos Junior Alcantara,Sergei L Kosakovsky Pond,Steven Weaver,Darren P. Martin,Richard J Lessells,Richard J Lessells,Jinal N. Bhiman,Jinal N. Bhiman,Carolyn Williamson,Carolyn Williamson,Tulio de Oliveira,Tulio de Oliveira,Tulio de Oliveira +60 more
TL;DR: In this paper, the authors describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y).
References
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Shedding of infectious virus in hospitalized patients with coronavirus disease-2019 (COVID-19): duration and key determinants
Jeroen J. A. van Kampen,David A. M. C. van de Vijver,Pieter L. A. Fraaij,Bart L. Haagmans,Mart M. Lamers,Nisreen M.A. Okba,Johannes P. C. van den Akker,Henrik Endeman,Diederik Gommers,Jan J. Cornelissen,Rogier A.S. Hoek,Menno M. van der Eerden,Dennis A. Hesselink,Herold J. Metselaar,Annelies Verbon,Jurriaan E. M. de Steenwinkel,Georgina I. Aron,Eric C. M. van Gorp,Sander van Boheemen,Jolanda J.C. Voermans,Charles A. Boucher,Richard Molenkamp,Marion Koopmans,Corine H. GeurtsvanKessel,Annemiek A. van der Eijk +24 more
TL;DR: Infectious virus shedding drops to undetectable levels below a viral RNA load threshold and once serum neutralizing antibodies are present, which warrants the use of quantitative viralRNA load assays and serological assays in test-based strategies to discontinue or de-escalate infection prevention and control precautions.
Journal ArticleDOI
Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma.
Eric Salazar,Katherine K. Perez,Madiha Ashraf,Jian Chen,Brian Castillo,Paul A. Christensen,Taryn A Eubank,David W. Bernard,Todd N. Eagar,S. Wesley Long,Sishir Subedi,Randall J. Olsen,Christopher Leveque,Mary R. Schwartz,Monisha Dey,Cheryl Chavez-East,John Rogers,Ahmed Shehabeldin,David Joseph,Guy Williams,Karen D. Thomas,Faisal Masud,Christina Talley,Katharine G. Dlouhy,Bevin Valdez Lopez,Curt Hampton,Jason J. Lavinder,Jimmy Gollihar,Andre C. Maranhao,Gregory C. Ippolito,Matthew Ojeda Saavedra,Concepcion C. Cantu,Prasanti Yerramilli,Layne Pruitt,James M. Musser,James M. Musser +35 more
TL;DR: Administration of convalescent plasma is a safe treatment option for those with severe COVID-19 disease, and whole genome sequencing data did not identify a strain genotype-disease severity correlation.
Posted ContentDOI
The architecture of SARS-CoV-2 transcriptome
TL;DR: A high-resolution map of the SARS-CoV-2 transcriptome and epitranscriptome is provided using nanopore direct RNA sequencing and DNA nanoball sequencing, finding at least 41 potential RNA modification sites with an AAGAA motif.
Journal ArticleDOI
Prolonged Persistence of SARS-CoV-2 RNA in Body Fluids.
Jiufeng Sun,Jianpeng Xiao,Ruilin Sun,Xi Tang,Chumin Liang,Huifang Lin,Lilian Zeng,Jianxiong Hu,Runyu Yuan,Pingping Zhou,Jinju Peng,Qianlin Xiong,Fengfu Cui,Zhe Liu,Jing Lu,Junzhang Tian,Wenjun Ma,Changwen Ke +17 more
TL;DR: The frequency and duration of detectable severe acute respiratory syndrome coronavirus 2 RNA in human body fluids is estimated and the prolonged persistence of virus RNA in various body fluids may guide the clinical diagnosis and prevention of onward virus transmission.
Posted ContentDOI
Detection of Nucleocapsid Antibody to SARS-CoV-2 is More Sensitive than Antibody to Spike Protein in COVID-19 Patients.
Peter D. Burbelo,Francis X. Riedo,Chihiro Morishima,Stephen A. Rawlings,Davey M. Smith,Sanchita Das,Jeffrey R Strich,Daniel S. Chertow,Richard T. Davey,Jeffrey I. Cohen +9 more
TL;DR: Analysis of heat-inactivated samples by LIPS is a safe and sensitive method for detecting SARS-CoV-2 antibodies, which is more sensitive than spike protein antibody for detecting early infection.
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