CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation
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TLDR
The behavioral phenotype is due to an acute requirement for CBP HAT activity in the adult as it is rescued by both suppression of transgene expression or by administration of the histone deacetylase inhibitor Trichostatin A in adult animals.About:
This article is published in Neuron.The article was published on 2004-06-24 and is currently open access. It has received 814 citations till now. The article focuses on the topics: Histone acetyltransferase activity & Epigenetics in learning and memory.read more
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Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Nadia M. Tsankova,Olivier Berton,William Renthal,Arvind Kumar,Rachel L. Neve,Eric J. Nestler +5 more
TL;DR: An important role for histone remodeling in the pathophysiology and treatment of depression is underscored and the therapeutic potential for hist one methylation and deacetylation inhibitors in depression is highlighted.
Journal ArticleDOI
HDAC2 negatively regulates memory formation and synaptic plasticity
Ji-Song Guan,Stephen J. Haggarty,Emanuela Giacometti,Jan Hermen Dannenberg,Jan Hermen Dannenberg,Nadine F. Joseph,Nadine F. Joseph,Jun Gao,Thomas J.F. Nieland,Ying Zhou,X. L. Wang,Ralph Mazitschek,James E. Bradner,Ronald A. DePinho,Rudolf Jaenisch,Li-Huei Tsai,Li-Huei Tsai +16 more
TL;DR: It is suggested that HDAC2 functions in modulating synaptic plasticity and long-lasting changes of neural circuits, which in turn negatively regulates learning and memory.
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Epigenetic regulation in psychiatric disorders
TL;DR: This review summarizes recent evidence for the existence of sustained epigenetic mechanisms of gene regulation in neurons that have been implicated in the regulation of complex behaviour, including abnormalities in several psychiatric disorders such as depression, drug addiction and schizophrenia.
Journal ArticleDOI
Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Recovery of learning and memory is associated with chromatin remodelling
Andre Fischer,Farahnaz Sananbenesi,Xinyu Wang,Xinyu Wang,Xinyu Wang,Matthew Dobbin,Matthew Dobbin,Matthew Dobbin,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +10 more
TL;DR: It is shown that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred, and suggests that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment.
References
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
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A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
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Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning
R. G. Phillips,Joseph E. LeDoux +1 more
TL;DR: An associative roles for the amygdala and a sensory relay role for the hippocampus are suggested in fear conditioning, which is involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli.
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The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
TL;DR: It is demonstrated that p300/CBP acetylates nucleosomes in concert with PCAF, a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyl transferases.