Journal ArticleDOI
Cell therapy for Parkinson′s disease is coming of age: current challenges and future prospects with a focus on immunomodulation
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TLDR
The factors that affect the outcome of cell therapy in PD are discussed, with focus on the cell types used and the functional effects of the host immune response on graft survival and differentiation.Abstract:
Parkinson’s disease (PD) is a neurodegenerative disease that affects more than 1% of people over the age of 60. The principal feature of this disease is the progressive loss of dopaminergic neurons (DAn) within the nigrostriatal system, causing the motor symptoms observed in these patients. At present, there is no therapeutic approach with a cytoprotective effect that can prevent DAn cell death or disease progression. Cell replacement therapy began 30 years ago with the objective to compensate for the loss of DAn by transplantation of dopamine-producing cells. The results from these trials have provided proof of concept of safety and efficacy of cell replacement. However, a major limiting factor of this strategy has been the poor survival rate of grafted DAn. An important factor that could cause cell death of DA precursors is the host response to the graft. In this review, we discuss the factors that affect the outcome of cell therapy in PD, with focus on the cell types used and the functional effects of the host immune response on graft survival and differentiation. We also discuss the strategies that may increase the efficacy of cell replacement therapy which target the host immune response.read more
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Parkinson's disease, aging and adult neurogenesis: Wnt/β-catenin signalling as the key to unlock the mystery of endogenous brain repair.
Bianca Marchetti,Cataldo Tirolo,Francesca L'Episcopo,Salvatore Caniglia,Nunzio Testa,Jayden A. Smith,Stefano Pluchino,M.F. Serapide +7 more
TL;DR: Harnessing WβC‐signalling in the aged PD brain can restore neurogenesis, rejuvenate the microenvironment, and promote neurorescue and regeneration.
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Synergistic Photothermal and Chemical Therapy by Smart Dual-Functional Graphdiyne Nanosheets for Treatment of Parkinson's Disease
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LncRNA OIP5-AS1 reduces α-synuclein aggregation and toxicity by targeting miR-126 to activate PLK2 in human neuroblastoma SH-SY5Y cells.
Zhiwei Song,Baoming Xie +1 more
TL;DR: The data indicate that OIP5-AS1 promotes the autophagy of PLK2-α-synuclein by targeting the miR-126 axis with pathogenic factors, thus reducing the aggregation toxicity of α- synuclein, which will help better to understand the mechanism of dopaminergic neuron loss in PD and provide novel treatment options.
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Inflammatory Mechanisms in Parkinson's Disease: From Pathogenesis to Targeted Therapies.
Stellina Y H Lee,Nathanael J. Yates,Nathanael J. Yates,Susannah J. Tye,Susannah J. Tye,Susannah J. Tye +5 more
TL;DR: In this article, the authors summarize the data about main inflammatory biomarkers described in Parkinson's disease to date and their potential for regulation as a novel target for disease-modifying pharmacological strategies.
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Glial cells in intracerebral transplantation for Parkinson's disease.
TL;DR: Recognizing and utilizing glial reactivity can move translational research forward and provide an insight not only to post-transplantation events but also to mechanisms of neuronal death and degeneration.
References
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors (GBD) study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions as discussed by the authors.
Journal ArticleDOI
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
Sonja Kriks,Jae-Won Shim,Jinghua Piao,Yosif Ganat,Dustin R. Wakeman,Zhi-Zhong Xie,Luis Carrillo-Reid,Gordon Auyeung,Chris Antonacci,Amanda Buch,Lichuan Yang,M. Flint Beal,D. James Surmeier,Jeffrey H. Kordower,Viviane Tabar,Lorenz Studer +15 more
TL;DR: A novel floor-plate-based strategy for the derivation of human DA neurons that efficiently engraft in vivo is presented, suggesting that past failures were due to incomplete specification rather than a specific vulnerability of the cells.
Journal ArticleDOI
Global, regional, and national burden of neurological disorders during 1990-2015
Valery L. Feigin,Amanuel Alemu Abajobir,Kalkidan Hassen Abate,Foad Abd-Allah,Abdishakur M. Abdulle,Semaw Ferede Abera,Gebre Yitayih Abyu,Muktar Beshir Ahmed,Amani Nidhal Aichour,Ibtihel Aichour,Miloud Taki Eddine Aichour,Rufus Akinyemi,Samer Alabed,Rajaa Al-Raddadi,Nelson Alvis-Guzman,Azmeraw T. Amare,Hossein Ansari,Palwasha Anwari,Johan Ärnlöv,Hamid Asayesh,Solomon Weldegebreal Asgedom,Tesfay Mehari Atey,Leticia Avila-Burgos,Euripide Frinel G Arthur Avokpaho,Mahmood Reza Azarpazhooh,Aleksandra Barac,Miguel A Barboza,Suzanne Barker-Collo,Till Baernighausen,Neeraj Bedi,Ettore Beghi,Derrick A Bennett,Isabela M. Benseñor,Adugnaw Berhane,Balem Demtsu Betsu,Soumyadeep Bhaumik,Sait Mentes Birlik,Stan Biryukov,Dube Jara Boneya,Lemma NegesaBulto Bulto,Hélène Carabin,Daniel C Casey,Carlos A Castañeda-Orjuela,Ferrán Catalá-López,Honglei Chen,Abdulaal A Chitheer,Rajiv Chowdhury,Hanne Christensen,Lalit Dandona,Rakhi Dandona,Gabrielle deVeber,Samath D Dharmaratne,Huyen Phuc Do,Klara Dokova,E. Ray Dorsey,Richard G. Ellenbogen,Sharareh Eskandarieh,Maryam S. Farvid,Seyed-Mohammad Fereshtehnejad,Florian Fischer,Kyle J Foreman,Johanna M. Geleijnse,Richard F. Gillum,Giorgia Giussani,Ellen M Goldberg,Philimon Gona,Alessandra C. Goulart,Harish Chander Gugnani,Rashmi Gupta,Rajeev Gupta,Vladimir Hachinski,Randah R. Hamadeh,Mitiku Teshome Hambisa,Graeme J. Hankey,Habtamu Abera Hareri,Rasmus Havmoeller,Simon I. Hay,Pouria Heydarpour,Peter J. Hotez,Mihajlo Jakovljevic,Mehdi Javanbakht,Panniyammakal Jeemon,Jost B. Jonas,Yogeshwar Kalkonde,Amit Kandel,André Karch,Amir Kasaeian,Anshul Kastor,Peter Njenga Keiyoro,Yousef Khader,Ibrahim A Khalil,Ejaz Ahmad Khan,Young-Ho Khang,Abdullah T Khoja,Jagdish Khubchandani,Chanda Kulkarni,Daniel Kim,Yun Jin Kim,Mika Kivimäki,Yoshihiro Kokubo,Soewarta Kosen,Michael Kravchenko,Rita Krishnamurthi,Barthelemy Kuate Defo,G Anil Kumar,Rashmi Kumar,Hmwe H Kyu,Anders Larsson,Pablo M. Lavados,Yongmei Li,Xiaofeng Liang,Misgan Legesse Liben,Warren D. Lo,Giancarlo Logroscino,Paulo A. Lotufo,Clement T. Loy,Mark T Mackay,Hassan Magdy Abd El Razek,Mohammed Magdy Abd El Razek,Azeem Majeed,Reza Malekzadeh,Treh Manhertz,Lorenzo G. Mantovani,João Massano,Mohsen Mazidi,Colm McAlinden,Suresh Mehata,Man Mohan Mehndiratta,Ziad A. Memish,Walter Mendoza,Mubarek Abera Mengistie,George A. Mensah,Atte Meretoja,Haftay Berhane Mezgebe,Ted R. Miller,Shiva Raj Mishra,Norlinah Mohamed Ibrahim,Alireza Mohammadi,Kedir Endris Mohammed,Shafiu Mohammed,Ali H. Mokdad,Maziar Moradi-Lakeh,Ilais Moreno Velásquez,Kamarul Imran Musa,Mohsen Naghavi,Josephine W. Ngunjiri,Cuong Tat Nguyen,Grant Nguyen,Quyen Nguyen,Trang Huyen Nguyen,Emma Nichols,Dina Nur Anggraini Ningrum,Vuong Minh Nong,Bo Norrving,Jean Jacques Noubiap,Felix Akpojene Ogbo,Mayowa O. Owolabi,Jeyaraj D Pandian,P. Parmar,David M. Pereira,Max Petzold,Michael R. Phillips,Michael A. Piradov,Richie Poulton,Farshad Pourmalek,Mostafa Qorbani,Anwar Rafay,Mahfuzar Rahman,Mohammad Hifz Ur Rahman,Rajesh Kumar Rai,Sasa Rajsic,Annemarei Ranta,Salman Rawaf,Andre M. N. Renzaho,Mohammad Sadegh Rezai,Gregory A. Roth,Gholamreza Roshandel,Enrico Rubagotti,Perminder S. Sachdev,Saeid Safiri,Ramesh Sahathevan,Mohammad Ali Sahraian,Abdallah M. Samy,Paula Santalucia,Itamar S. Santos,Benn Sartorius,Maheswar Satpathy,Monika Sawhney,Mete Saylan,Sadaf G. Sepanlou,Masood Ali Shaikh,Raad Shakir,Morteza Shamsizadeh,Kevin N. Sheth,Mika Shigematsu,Haitham Shoman,Diego Augusto Santos Silva,Mari Smith,Eugene Sobngwi,Luciano A. Sposato,Jeffrey D. Stanaway,Dan J. Stein,Timothy J. Steiner,Lars Jacob Stovner,Rizwan Suliankatchi Abdulkader,Cassandra Szoeke,Rafael Tabarés-Seisdedos,David Tanne,Alice Theadom,Amanda G. Thrift,David L. Tirschwell,Roman Topor-Madry,Bach Xuan Tran,Thomas Truelsen,Kald Beshir Tuem,Kingsley N. Ukwaja,Olalekan A. Uthman,Yuri Y Varakin,Tommi Vasankari,Narayanaswamy Venketasubramanian,Vasiliy Victorovich Vlassov,Fiseha Wadilo,Tolassa Wakayo,Mitchell T. Wallin,Elisabete Weiderpass,Ronny Westerman,Tissa Wijeratne,Charles Shey Wiysonge,Minyahil Alebachew Woldu,Charles D.A. Wolfe,Denis Xavier,Gelin Xu,Yuichiro Yano,Hassen Hamid Yimam,Naohiro Yonemoto,Chuanhua Yu,Zoubida Zaidi,Maysaa El Sayed Zaki,Joseph R. Zunt,Christopher J L Murray,Theo Vos,Gbd Neurological Disorders +241 more
Journal ArticleDOI
Health benefits of docosahexaenoic acid (DHA)
Lloyd A. Horrocks,Young K. Yeo +1 more
TL;DR: The association of DHA deficiency with depression is the reason for the robust positive correlation between depression and myocardial infarction, and patients with cardiovascular disease or Type II diabetes are often advised to adopt a low-fat diet with a high proportion of carbohydrate.
Journal ArticleDOI
Parkinson's disease: from monogenic forms to genetic susceptibility factors
Suzanne Lesage,Alexis Brice +1 more
TL;DR: Genome-wide associations and re-sequencing projects, together with gene-environment interaction studies, are expected to further define the causal role of genetic determinants in the pathogenesis of PD, and improve prevention and treatment.