Journal ArticleDOI
Chemically defined media for commercial fermentations
J. Zhang,Randolph Greasham +1 more
TLDR
In this paper, the authors focus on the application, development, and practical considerations of fermentations in chemically defined media in an industrial environment and present a review of the application and process economics of such media.Abstract:
The use of chemically defined media is gaining popularity in some commercial fermentations, particularly for the preparation of biological products. Although these media are still not frequently developed for industrial processes, they do exhibit favorable characteristics at large scale that are not observed with traditional complex media. This review focuses on the application, development, and practical considerations, especially process economics, of fermentations in chemically defined media in an industrial environment.read more
Citations
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Journal ArticleDOI
Identification and characterization of IS1 transposition in plasmid amplification mutants of E. coli clones producing DNA vaccines
TL;DR: The results suggest the presence of an IS1 insertional mutation that affects plasmid replication and amplification, possibly in a position-dependent manner.
Journal ArticleDOI
Trehalose accumulation in Saccharomyces cerevisiae cells: experimental data and structured modeling
TL;DR: Experimental results show that yeast can accumulate trehalose up to 13% of biomass dry weight under carbon or nitrogen starvation and a compartmentalized and biochemically structured model is proposed in order to mathematically describe these experimental findings.
Journal ArticleDOI
Multi-Factorial-Guided Media Optimization for Enhanced Biomass and Lipid Formation by the Oleaginous Yeast Cutaneotrichosporon oleaginosus
TL;DR: The data indicate that a metabolic ceiling for lipid accumulation in C. oleaginosus is obtained with the correct carbon and nitrogen source mixture, and with ammonium salts as a N-source, the intracellularly accumulated triglycerides increasingly contain saturated fatty acids, which provides a new route to generate tailored fatty acid profiles for specific oleochemicals or food applications.
Journal ArticleDOI
Phenotyping the quality of complex medium components by simple online-monitored shake flask experiments
Sylvia Diederichs,Anna Korona,Antje Staaden,Wolfgang Kroutil,Kohsuke Honda,Hisao Ohtake,Jochen Büchs +6 more
TL;DR: This work proves that cultivations conducted in complex media may be prone to significant variation in final product quality and quantity if the quality of the raw material for medium preparation is not thoroughly checked.
Journal ArticleDOI
Optimization of Fermentation Conditions for Recombinant Human Interferon Beta Production by Escherichia coli Using the Response Surface Methodology
Mohammad Hossein Morowvat,Mohammad Hossein Morowvat,Valiollah Babaeipour,Valiollah Babaeipour,Hamid Rajabi Memari,Hossein Vahidi +5 more
TL;DR: It can be concluded that the RSM is an effective method for the optimization of recombinant protein expression using synthetic genes in E. coli to exploit the best results condition for rhIFN-β in a bench top bioreactor.
References
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Journal ArticleDOI
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R. L. Plackett,J. P. Burman +1 more
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Journal ArticleDOI
Growth characteristics of group A streptococci in a new chemically defined medium.
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TL;DR: A new chemically defined medium for the growth of group A streptococci has been formulated and the production of virulence factors and extracellular enzymes during growth in this new medium was comparable to that in complex media.
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