Journal ArticleDOI
Chemically defined media for commercial fermentations
J. Zhang,Randolph Greasham +1 more
TLDR
In this paper, the authors focus on the application, development, and practical considerations of fermentations in chemically defined media in an industrial environment and present a review of the application and process economics of such media.Abstract:
The use of chemically defined media is gaining popularity in some commercial fermentations, particularly for the preparation of biological products. Although these media are still not frequently developed for industrial processes, they do exhibit favorable characteristics at large scale that are not observed with traditional complex media. This review focuses on the application, development, and practical considerations, especially process economics, of fermentations in chemically defined media in an industrial environment.read more
Citations
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Journal ArticleDOI
Developments in industrially important thermostable enzymes: a review.
TL;DR: The source microorganisms and properties of thermostable starch hydrolysing amylases, xylanases, cellulases, chitinases, proteases, lipases and DNA polymerases are discussed and the industrial needs for such specific thermostably enzyme and improvements required to maximize their application in the future are suggested.
Journal ArticleDOI
Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements.
TL;DR: The current technology used for commercial production of recombinant therapeutics in E. coli is summarized and recent advances that can potentially expand the use of this system toward more sophisticated protein therapeutics are summarized.
Journal ArticleDOI
Review of xanthan gum production from unmodified starches by Xanthomonas comprestris sp.
S. Rosalam,R. England +1 more
TL;DR: In this paper, the unstructured kinetics and the structured kinetics models were described in batch processes but the continuous kinetic model is insufficiently cared, and the problem of limited oxygen transfer suggests that a new bioreactor design is required.
Journal ArticleDOI
High-cell-density cultivation of microorganisms.
D Riesenberg,R Guthke +1 more
TL;DR: Development in the application of multivariate statistical control, artificial neural networks, fuzzy control and knowledge-based supervision (expert systems) are summarized for high-cell-density cultivation, with emphasis on robust fermentation control.
Journal ArticleDOI
Studies on production of thermostable alkaline protease from thermophilic and alkaliphilic Bacillus sp. JB-99 in a chemically defined medium
B. Johnvesly,G. R. Naik +1 more
TL;DR: The thermophilic and alkaliphilic Bacillus sp. JB-99 was isolated from sugarcane molasses and was cultured in 250 ml Erlenmeyer flasks containing 50 ml of synthetic medium consisting of (g/l): citric acid; 10.0, NaNO 3 ; 10.
References
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Journal ArticleDOI
Production of poly(3‐hydroxybutyric acid) by fed‐batch culture of Alcaligenes eutrophus with glucose concentration control
TL;DR: The final cell concentration, PHB concentration, and PHB productivity increased as ammonia feeding was stopped at a higher cell concentration and the effect of ammonium limitation on PHB synthesis at different culture phases was studied.
Book ChapterDOI
High Cell-Density Fermentation
TL;DR: The information in this chapter should enable a reader with little or no experience to perform a high-cell density fermentation of a P. pastoris expression strain to achieve high expression levels with almost any good-quality fermentor, modified to accommodate this organism.
Journal ArticleDOI
Acetone and Butanol Production by Clostridium acetobutylicum in a Synthetic Medium.
TL;DR: The effect of the component concentrations of a synthetic medium on acetone and butanol fermentation by Clostridium acetobutylicum ATCC 824 was investigated and cell growth was dependent on the presence of Mg, Fe, and K in the medium.
Journal ArticleDOI
Genetic algorithms in chemistry
TL;DR: The ability to search a large parameter space with no initial guesses per se, no derivatives of the objective function and to cope with local minima, make it a candidate method for several areas of chemistry.
Journal ArticleDOI
A Synthetic Medium for Bacterial Cellulose Production by Acetobacter xylinum subsp. sucrofermentans
TL;DR: Of several organic nitrogen sources tested, corn steep liquor (CSL) was found to be the most suitable for cellulose production by Acetobacter xylinum subsp.
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