Journal ArticleDOI
Chemically defined media for commercial fermentations
J. Zhang,Randolph Greasham +1 more
TLDR
In this paper, the authors focus on the application, development, and practical considerations of fermentations in chemically defined media in an industrial environment and present a review of the application and process economics of such media.Abstract:
The use of chemically defined media is gaining popularity in some commercial fermentations, particularly for the preparation of biological products. Although these media are still not frequently developed for industrial processes, they do exhibit favorable characteristics at large scale that are not observed with traditional complex media. This review focuses on the application, development, and practical considerations, especially process economics, of fermentations in chemically defined media in an industrial environment.read more
Citations
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Developments in industrially important thermostable enzymes: a review.
TL;DR: The source microorganisms and properties of thermostable starch hydrolysing amylases, xylanases, cellulases, chitinases, proteases, lipases and DNA polymerases are discussed and the industrial needs for such specific thermostably enzyme and improvements required to maximize their application in the future are suggested.
Journal ArticleDOI
Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements.
TL;DR: The current technology used for commercial production of recombinant therapeutics in E. coli is summarized and recent advances that can potentially expand the use of this system toward more sophisticated protein therapeutics are summarized.
Journal ArticleDOI
Review of xanthan gum production from unmodified starches by Xanthomonas comprestris sp.
S. Rosalam,R. England +1 more
TL;DR: In this paper, the unstructured kinetics and the structured kinetics models were described in batch processes but the continuous kinetic model is insufficiently cared, and the problem of limited oxygen transfer suggests that a new bioreactor design is required.
Journal ArticleDOI
High-cell-density cultivation of microorganisms.
D Riesenberg,R Guthke +1 more
TL;DR: Development in the application of multivariate statistical control, artificial neural networks, fuzzy control and knowledge-based supervision (expert systems) are summarized for high-cell-density cultivation, with emphasis on robust fermentation control.
Journal ArticleDOI
Studies on production of thermostable alkaline protease from thermophilic and alkaliphilic Bacillus sp. JB-99 in a chemically defined medium
B. Johnvesly,G. R. Naik +1 more
TL;DR: The thermophilic and alkaliphilic Bacillus sp. JB-99 was isolated from sugarcane molasses and was cultured in 250 ml Erlenmeyer flasks containing 50 ml of synthetic medium consisting of (g/l): citric acid; 10.0, NaNO 3 ; 10.
References
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Journal ArticleDOI
Development of a synthetic medium for continuous anaerobic growth and ethanol production with a lactate dehydrogenase mutant of Bacillus stearothermophilus
TL;DR: A synthetic medium developed by the pulse and medium-shift technique for the continuous cultivation of Bacillus stearothermophilus strain LLD-15 (NCIMB 12428) is a promising candidate for the production of ethanol from pentoses and hexoses, using a high-temperature two-stage process.
Journal ArticleDOI
Pilot-scale harvest of recombinant yeast employing microfiltration: a case study
Gregory Russotti,A.Edward Osawa,Robert D. Sitrin,Barry C. Buckland,William R. Adams,Steven S. Lee +5 more
TL;DR: It was found that the major contributor to flux decay was reversible fouling by the cake formation on the membrane surface, thus controlling yeast microfiltration.
Journal ArticleDOI
Enhanced transformation of Streptococcus mutans by modifications in culture conditions.
Ging R. Shah,Page W. Caufield +1 more
Journal ArticleDOI
Reaction engineering analysis of L-lysine transport by Corynebacterium glutamicum.
Ralf Kelle,Birgit Laufer,Carsten Brunzema,Dirk Weuster-Botz,Reinhard Krämer,Christian Wandrey +5 more
TL;DR: In this article, a structured biochemical model of the L-lysine excretion mechanism was used to determine the activity of the export carrier and to calculate a cell-specific concentration of export carrier.
Journal ArticleDOI
Effect of Culture Conditions on Xylitol Production by Candida guilliermondii FTI 20037
Martin J. Pfeifer,Silvio Silvério da Silva,Maria das Graças de Almeida Felipe,Inês Conceição Roberto,Ismael Maciel de Mancilha +4 more
TL;DR: The use of D-xylose, the main component of xylan, to obtain chemical products has been a challenge in wood chemistry for the last 10 years.
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