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Chemically defined media for commercial fermentations
J. Zhang,Randolph Greasham +1 more
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In this paper, the authors focus on the application, development, and practical considerations of fermentations in chemically defined media in an industrial environment and present a review of the application and process economics of such media.Abstract:
The use of chemically defined media is gaining popularity in some commercial fermentations, particularly for the preparation of biological products. Although these media are still not frequently developed for industrial processes, they do exhibit favorable characteristics at large scale that are not observed with traditional complex media. This review focuses on the application, development, and practical considerations, especially process economics, of fermentations in chemically defined media in an industrial environment.read more
Citations
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Developments in industrially important thermostable enzymes: a review.
TL;DR: The source microorganisms and properties of thermostable starch hydrolysing amylases, xylanases, cellulases, chitinases, proteases, lipases and DNA polymerases are discussed and the industrial needs for such specific thermostably enzyme and improvements required to maximize their application in the future are suggested.
Journal ArticleDOI
Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements.
TL;DR: The current technology used for commercial production of recombinant therapeutics in E. coli is summarized and recent advances that can potentially expand the use of this system toward more sophisticated protein therapeutics are summarized.
Journal ArticleDOI
Review of xanthan gum production from unmodified starches by Xanthomonas comprestris sp.
S. Rosalam,R. England +1 more
TL;DR: In this paper, the unstructured kinetics and the structured kinetics models were described in batch processes but the continuous kinetic model is insufficiently cared, and the problem of limited oxygen transfer suggests that a new bioreactor design is required.
Journal ArticleDOI
High-cell-density cultivation of microorganisms.
D Riesenberg,R Guthke +1 more
TL;DR: Development in the application of multivariate statistical control, artificial neural networks, fuzzy control and knowledge-based supervision (expert systems) are summarized for high-cell-density cultivation, with emphasis on robust fermentation control.
Journal ArticleDOI
Studies on production of thermostable alkaline protease from thermophilic and alkaliphilic Bacillus sp. JB-99 in a chemically defined medium
B. Johnvesly,G. R. Naik +1 more
TL;DR: The thermophilic and alkaliphilic Bacillus sp. JB-99 was isolated from sugarcane molasses and was cultured in 250 ml Erlenmeyer flasks containing 50 ml of synthetic medium consisting of (g/l): citric acid; 10.0, NaNO 3 ; 10.
References
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Journal ArticleDOI
Nitrogen regulation of avermectins biosynthesis in Streptomyces avermitilis in a chemically defined medium
TL;DR: Of various amino acids tested, lysine and asparagine were found to be the best for the biosynthesis of AVMs, which was significantly affected by the nitrogen source used.
Journal ArticleDOI
Development of a defined medium and two-step culturing method for improved exotoxin A yields from Pseudomonas aeruginosa.
TL;DR: Northern blot analysis of total RNA isolates suggests that these effects on exotoxin A yields are based on events at the transcription level, and several divalent metallic cations (Ca2+, Cu2+, and Mn2+), in addition to iron, were found to inhibit the yield of exotoxins A.
Journal ArticleDOI
Fed-batch culture of Escherichia coli W by exponential feeding of sucrose as a carbon source
TL;DR: Fed-batch cultures of Escherichia coli W were carried out in a chemically defined medium containing sucrose as a sole carbon source and the final cell concentrations were obtained in 25 and 20 h, respectively.
Journal ArticleDOI
Instrumental Simplex Optimization: Experimental Illustrations for an Undergraduate Laboratory Course.
TL;DR: In this article, an analysis of the simplex method and simplex algorithm was performed in an undergraduate laboratory course using a simplex technique in an engineering course at the University of South Carolina.
Journal ArticleDOI
Hydraulic resistance and fouling of microfilters by Candida utilis in fermentation broth
TL;DR: The hydraulic resistance and membrane fouling effects of Candida utilis in fermentation broth were investigated using Millipore PVDF 0.22‐μm membranes (GVWP and GVHP) in a stirred‐cell system at 50 kPa and 700 rpm.
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