Journal ArticleDOI
Chemically defined media for commercial fermentations
J. Zhang,Randolph Greasham +1 more
TLDR
In this paper, the authors focus on the application, development, and practical considerations of fermentations in chemically defined media in an industrial environment and present a review of the application and process economics of such media.Abstract:
The use of chemically defined media is gaining popularity in some commercial fermentations, particularly for the preparation of biological products. Although these media are still not frequently developed for industrial processes, they do exhibit favorable characteristics at large scale that are not observed with traditional complex media. This review focuses on the application, development, and practical considerations, especially process economics, of fermentations in chemically defined media in an industrial environment.read more
Citations
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Journal ArticleDOI
ClearColi as a platform for untagged pneumococcal surface protein A production: cultivation strategy, bioreactor culture, and purification
Valdemir M. Cardoso,Sheyla Alexandra Hidalgo Paredes,Gilson Campani,Viviane Maimoni Gonçalves,Teresa Cristina Zangirolami +4 more
TL;DR: In this paper , an investigation of PspA4Pro production employing the endotoxin-free recombinant strain ClearColi® BL21(DE3) with different media (defined, auto-induction, and other complex media), temperatures (27, 32, and 37 °C), and inducers.
DissertationDOI
Engineering Escherichia coli for co-production of acetaldehyde and hydrogen from glucose
TL;DR: This chapter discusses the processing of biorenewable resources into fuels and chemicals by recombinant Escherichia coli through metabolic engineering, and the importance of returning to renewable resources.
Journal ArticleDOI
Avoiding amino acid depletion in a complex medium results in improved Escherichia coli BW25113 growth
TL;DR: The findings showed the deficiencies of the nutrient-rich medium and how rational medium design, based on consumption values, removed these shortcomings and the resulting balanced medium gives a high specific growth rate and is suitable for studying E. coli physiology at fast growth.
Journal ArticleDOI
Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
TL;DR: The applied Kriging Toolbox (KriKit) is a general tool for Design of Experiments (DOE) that contributes to improved holistic bioprocess optimization and supports multi-objective optimization which can be important in optimizing both upstream and downstream processes.
References
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R. L. Plackett,J. P. Burman +1 more
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A novel progressive spongiform encephalopathy in cattle.
G. A. H. Wells,A.C. Scott,C.T. Johnson,R.F. Gunning,R. D. Hancock,Martin Jeffrey,M. Dawson,R. Bradley +7 more
Book
Manual of industrial microbiology and biotechnology
Arnold L. Demain,Julian Davies +1 more
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Journal ArticleDOI
Growth characteristics of group A streptococci in a new chemically defined medium.
I van de Rijn,R E Kessler +1 more
TL;DR: A new chemically defined medium for the growth of group A streptococci has been formulated and the production of virulence factors and extracellular enzymes during growth in this new medium was comparable to that in complex media.
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