Journal ArticleDOI
Chemically defined media for commercial fermentations
J. Zhang,Randolph Greasham +1 more
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TLDR
In this paper, the authors focus on the application, development, and practical considerations of fermentations in chemically defined media in an industrial environment and present a review of the application and process economics of such media.Abstract:
The use of chemically defined media is gaining popularity in some commercial fermentations, particularly for the preparation of biological products. Although these media are still not frequently developed for industrial processes, they do exhibit favorable characteristics at large scale that are not observed with traditional complex media. This review focuses on the application, development, and practical considerations, especially process economics, of fermentations in chemically defined media in an industrial environment.read more
Citations
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Journal ArticleDOI
Hybrid Deep Modeling of a GS115 (Mut+) Pichia pastoris Culture with State–Space Reduction
TL;DR: In this paper , a hybrid deep modeling method with state-space reduction was developed and showcased with a P. pastoris GS115 Mut+ strain expressing a single-chain antibody fragment (scFv).
Book ChapterDOI
A Computational Intelligent Based Approach for the Development of a Minimal Defined Medium: Application to Human Interleukin-3 Production by Streptomyces lividans 66
TL;DR: A systematic approach was developed to identify and optimize the essential amino acids in defined minimal medium for the production of recombinant human interleukin-3 (rHuIL-3) by Streptomyces lividans using both statistical and neural network models.
Journal Article
Predicción del contenido intracelular de trehalosa en el proceso de producción de biomasa de Saccharomyces cerevisiae
TL;DR: An online estimation method to forecast real-time intracellular tre Halose content in yeast is developed, based on the main metabolic events involved in trehalose biosynthesis, as well as on a differential neural network algorithm to estimate trehalOSE concentration in the cytoplasm.
Dissertation
Produção e purificação de DNA plasmidial a partir de Escherichia coli recombinante
TL;DR: The velocity of agitation that provided highest results in relationship biomass and plasmid DNA production was 200 rpm and the concentrations 30 to 50μg mL of kanamycin provided similar results for all the studied conditions and the culture medium TB medium which showed of better results for the biomass production and DNA.
References
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Journal ArticleDOI
A novel progressive spongiform encephalopathy in cattle.
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Book
Manual of industrial microbiology and biotechnology
Arnold L. Demain,Julian Davies +1 more
TL;DR: The culture The process Strain Improvement Immobilization and Cell Culture Biochemical Engineering Special Topics as discussed by the authors The culture the process strain improvement Immobilisation and cell culture Biochemical engineering
Journal ArticleDOI
Growth characteristics of group A streptococci in a new chemically defined medium.
I van de Rijn,R E Kessler +1 more
TL;DR: A new chemically defined medium for the growth of group A streptococci has been formulated and the production of virulence factors and extracellular enzymes during growth in this new medium was comparable to that in complex media.
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