Journal ArticleDOI
Chemically defined media for commercial fermentations
J. Zhang,Randolph Greasham +1 more
TLDR
In this paper, the authors focus on the application, development, and practical considerations of fermentations in chemically defined media in an industrial environment and present a review of the application and process economics of such media.Abstract:
The use of chemically defined media is gaining popularity in some commercial fermentations, particularly for the preparation of biological products. Although these media are still not frequently developed for industrial processes, they do exhibit favorable characteristics at large scale that are not observed with traditional complex media. This review focuses on the application, development, and practical considerations, especially process economics, of fermentations in chemically defined media in an industrial environment.read more
Citations
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Optimizing of Nutrients for High Level Expression of Recombinant Streptokinase Using pET32a Expression System.
Shima Mahmoudi,Hamid Abtahi,Abbas Bahador,Ghasem Mosayebi,Ali Hatef Salmanian,Mostafa Teymuri +5 more
TL;DR: It is demonstrated that significant improvement in the streptokinase yield can be obtained by modifying the media and feeding of substrate and this results indicate that efficient process control strategy is important for the mass production of strePTokinase.
Journal ArticleDOI
Production of amylase and chlamydospores by Piriformospora indica, a root endophytic fungus
TL;DR: Batch cultivation of the fungus Piriformospora indica on Kaefer medium containing soluble starch resulted in a 1.5-fold improvement in amyl enzyme activity and a reduction in the time required for achieving maximum growth, amylase activity and spore yield by more than 50%.
Journal ArticleDOI
Optimization of cell growth and bacoside-A production in suspension cultures of Bacopa monnieri (L.) Wettst. using response surface methodology
TL;DR: The present study results show the successful application of RSM to enhance the production of biomass and accumulation of bacoside-A content in cell suspension cultures of B. monnieri.
Patent
Novel engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same
TL;DR: The inventive rumen bacterial mutant has the property of having a high growth rate and succinic acid productivity while producing little or no other organic acids in anaerobic conditions as mentioned in this paper.
Patent
Fed-batch fermentation process and culture medium for the production of plasmid dna in e. coli on a manufacturing scale
TL;DR: In this article, a pre-culture and fed batch process for producing plasmid DNA E. coli cells is described, where the culture media of the batch phase and the culture medium added during the feeding phase are chemically defined.
References
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Journal ArticleDOI
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TL;DR: A new chemically defined medium for the growth of group A streptococci has been formulated and the production of virulence factors and extracellular enzymes during growth in this new medium was comparable to that in complex media.
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