Chikungunya virus, southeastern France.
Marc Grandadam,Valérie Caro,Sébastien Plumet,Jean Michel Thiberge,Yvan Souares,Anna-Bella Failloux,Hugues Tolou,Michel Budelot,Didier Cosserat,Isabelle Leparc-Goffart,Philippe Desprès +10 more
TLDR
Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the chikungunya virus in Europe.Abstract:
In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe.read more
Citations
More filters
Journal ArticleDOI
Ongoing and emerging arbovirus threats in Europe.
TL;DR: The rise in global travel and trade has posed Europe to an increased risk of introduction and expansion of exotic arthropod vectors and autochthonous transmission of arboviruses, like dengue and chikungunya viruses, following new introductions from endemic areas.
Journal ArticleDOI
Two novel epistatic mutations (E1:K211E and E2:V264A) in structural proteins of Chikungunya virus enhance fitness in Aedes aegypti
TL;DR: Results indicate that adaptive mutations in CHIKV are leading to efficientCHIKV circulation in Ae.
Journal ArticleDOI
Interspecies transmission and chikungunya virus emergence
TL;DR: A major determinant of CHIKV endemic stability in the Americas will be its ability to spill back into an enzootic cycle involving sylvatic vectors and nonhuman primates, an opportunity exploited by yellow fever virus but apparently not by dengue viruses.
Journal ArticleDOI
Cross-protective immunity against o'nyong-nyong virus afforded by a novel recombinant chikungunya vaccine.
Charalambos D. Partidos,Joanna Paykel,James Weger,Erin M. Borland,Ann M. Powers,Robert L. Seymour,Scott C. Weaver,Dan T. Stinchcomb,Jorge E. Osorio +8 more
TL;DR: It is demonstrated that a single dose of CHikV/IRES elicited a strong cross-neutralizing antibody response and conferred protection against ONNV challenge in the A129 mouse model, highlighting the potential of the CHIKV/ IRES vaccine to protect humans against not only chikungunya virus but also against OnnV-induced disease.
Journal ArticleDOI
Chikungunya virus infection of cell lines: analysis of the East, Central and South African lineage.
TL;DR: The results suggest that the increased infectivity seen in insect cells derives from an evolution of the CHIKV genome not solely associated with the E1:226 substitution, as well as generating a comprehensive virus production profile for one of the newer isolates.
References
More filters
Journal ArticleDOI
J. Virol. Methods: Corrigendum to “Detection of stylet-borne and circulative potato viruses in aphids by duplex reverse transcription polymerase chain reaction” [59 (1996) 189]
Journal ArticleDOI
Infection with chikungunya virus in Italy: an outbreak in a temperate region
Giovanni Rezza,Loredana Nicoletti,R Angelini,Roberto Romi,A C Finarelli,M. Panning,Paolo Cordioli,Claudia Fortuna,S. Boros,Fabio Magurano,G. Silvi,Paola Angelini,Michele Dottori,Maria Grazia Ciufolini,Giancarlo Majori,Antonio Cassone +15 more
TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.
Journal ArticleDOI
A single mutation in chikungunya virus affects vector specificity and epidemic potential.
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Journal ArticleDOI
Present and future arboviral threats.
TL;DR: Viruses such as dengue (DENV) and chikungunya (CHIKV) that have lost the requirement for enzootic amplification now produce extensive epidemics in tropical urban centers, and climate warming could facilitate the expansion of the distributions of many arboviruses.
Journal ArticleDOI
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
Related Papers (5)
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more