Chikungunya virus, southeastern France.
Marc Grandadam,Valérie Caro,Sébastien Plumet,Jean Michel Thiberge,Yvan Souares,Anna-Bella Failloux,Hugues Tolou,Michel Budelot,Didier Cosserat,Isabelle Leparc-Goffart,Philippe Desprès +10 more
TLDR
Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the chikungunya virus in Europe.Abstract:
In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe.read more
Citations
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Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection
Rachel Bellone,Rachel Bellone,Sebastian Lequime,Sebastian Lequime,Henri Jupille,Giel P. Göertz,Fabien Aubry,Fabien Aubry,Laurence Mousson,Géraldine Piorkowski,Pei-Shi Yen,Gaelle Gabiane,Marie Vazeille,Anavaj Sakuntabhai,Gorben P. Pijlman,Xavier de Lamballerie,Louis Lambrechts,Louis Lambrechts,Anna-Bella Failloux +18 more
TL;DR: It is shown that the 10,418 mutation alone does not confer a detectable increase in transmission efficiency in vivo, and the role of epistasis in shaping evolutionary trajectories of DENV variants is emphasized.
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A New Multiplex RT-qPCR Method for the Simultaneous Detection and Discrimination of Zika and Chikungunya Viruses
Sylvia Broeders,Linda Garlant,Marie-Alice Fraiture,Els Vandermassen,Vanessa Suin,Jessica Vanhomwegen,Myrielle Dupont-Rouzeyrol,Dominique Rousset,Steven Van Gucht,Nancy H. C. Roosens +9 more
TL;DR: The full validation approach showed that the new four-plex method allows the specific and sensitive identification and discrimination of ZIKV and CHIKV in routine samples, and PCR is a reliable user-friendly technique that can be applied in remote areas.
Journal ArticleDOI
La dengue en France métropolitaine
TL;DR: The diagnosis of dengue, and chikungunya should be considered in case of suggestive symptoms in patients returning from an area of virus circulation, as the risk of autochthonous transmission increases every year.
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Development of a SYBR green I-based quantitative RT-PCR for Ross River virus: Application in vector competence studies and antiviral drug evaluation
Paban Kumar Dash,Ankita Agarwal,Shashi Sharma,Amrita Saha,Gaurav Joshi,Natarajan Gopalan,D. Sukumaran,Manmohan Parida +7 more
TL;DR: It was shown that Indian Ae.
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Alphavirus capsid proteins self‐assemble into core‐like particles in insect cells: A promising platform for nanoparticle vaccine development
Mia C. Hikke,Corinne Geertsema,Vincen Wu,Stefan W. Metz,Jan W. M. van Lent,Just M. Vlak,Gorben P. Pijlman +6 more
TL;DR: It is proposed that immunogenic epitope‐tagged alphavirus CLPs produced in insect cells present a simple and perhaps more stable alternative to alphvirus eVLPs.
References
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Infection with chikungunya virus in Italy: an outbreak in a temperate region
Giovanni Rezza,Loredana Nicoletti,R Angelini,Roberto Romi,A C Finarelli,M. Panning,Paolo Cordioli,Claudia Fortuna,S. Boros,Fabio Magurano,G. Silvi,Paola Angelini,Michele Dottori,Maria Grazia Ciufolini,Giancarlo Majori,Antonio Cassone +15 more
TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.
Journal ArticleDOI
A single mutation in chikungunya virus affects vector specificity and epidemic potential.
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Journal ArticleDOI
Present and future arboviral threats.
TL;DR: Viruses such as dengue (DENV) and chikungunya (CHIKV) that have lost the requirement for enzootic amplification now produce extensive epidemics in tropical urban centers, and climate warming could facilitate the expansion of the distributions of many arboviruses.
Journal ArticleDOI
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
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