Chikungunya virus, southeastern France.
Marc Grandadam,Valérie Caro,Sébastien Plumet,Jean Michel Thiberge,Yvan Souares,Anna-Bella Failloux,Hugues Tolou,Michel Budelot,Didier Cosserat,Isabelle Leparc-Goffart,Philippe Desprès +10 more
TLDR
Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the chikungunya virus in Europe.Abstract:
In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe.read more
Citations
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Journal ArticleDOI
Chikungunya Virus: Evolution and Genetic Determinants of Emergence
TL;DR: The A. albopictus-adaptive A226V substitution that is facilitating the dramatic geographic spread CHIKV epidemics, was prevented for decades or longer from being selected in most African enzootic strains as well as in the older endemic Asian lineage.
Journal ArticleDOI
Attenuation of Chikungunya Virus Vaccine Strain 181/Clone 25 Is Determined by Two Amino Acid Substitutions in the E2 Envelope Glycoprotein
Rodion Gorchakov,Eryu Wang,Grace Leal,Naomi L. Forrester,Kenneth S. Plante,Shannan L. Rossi,Charalambos D. Partidos,A. Paige Adams,Robert L. Seymour,James Weger,Erin M. Borland,Michael B. Sherman,Ann M. Powers,Jorge E. Osorio,Scott C. Weaver +14 more
TL;DR: Results indicate that the attenuation of strain 181/clone 25 is mediated by two point mutations, explaining the phenotypic instability observed in human vaccinees and also in the authors' studies.
Journal ArticleDOI
Chikungunya virus-vector interactions.
TL;DR: This review presents current understanding of CHIKV infection dynamics in mosquito vectors and its relationship to human disease emergence and the potential for re-emergence and expansion into new areas and prospects for prevention via vector control.
Journal ArticleDOI
Zika virus infection in a traveller returning to Europe from Brazil, March 2015
Lorenzo Zammarchi,Dennis Tappe,Claudia Fortuna,Maria Elena Remoli,Stephan Günther,Giulietta Venturi,Alessandro Bartoloni,Jonas Schmidt-Chanasit +7 more
TL;DR: The case highlights that, together with chikungunya virus and dengue virus, three major arboviruses are now co-circulating in Brazil, and represents a burden for the healthcare systems in Brazil and other countries where competent mosquito vectors are present.
Journal ArticleDOI
Alphaviruses: Population genetics and determinants of emergence
TL;DR: This review discusses the ecology, epidemiology and molecular virology of the alphaviruses, then focuses on three of the most important members of the genus: Venezuelan and eastern equine encephalitis and chikungunya viruses, with emphasis on their genetics and emergence mechanisms.
References
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Infection with chikungunya virus in Italy: an outbreak in a temperate region
Giovanni Rezza,Loredana Nicoletti,R Angelini,Roberto Romi,A C Finarelli,M. Panning,Paolo Cordioli,Claudia Fortuna,S. Boros,Fabio Magurano,G. Silvi,Paola Angelini,Michele Dottori,Maria Grazia Ciufolini,Giancarlo Majori,Antonio Cassone +15 more
TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.
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A single mutation in chikungunya virus affects vector specificity and epidemic potential.
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Journal ArticleDOI
Present and future arboviral threats.
TL;DR: Viruses such as dengue (DENV) and chikungunya (CHIKV) that have lost the requirement for enzootic amplification now produce extensive epidemics in tropical urban centers, and climate warming could facilitate the expansion of the distributions of many arboviruses.
Journal ArticleDOI
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
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