Chikungunya virus, southeastern France.
Marc Grandadam,Valérie Caro,Sébastien Plumet,Jean Michel Thiberge,Yvan Souares,Anna-Bella Failloux,Hugues Tolou,Michel Budelot,Didier Cosserat,Isabelle Leparc-Goffart,Philippe Desprès +10 more
TLDR
Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the chikungunya virus in Europe.Abstract:
In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe.read more
Citations
More filters
Journal ArticleDOI
Preliminary report of an autochthonous chikungunya outbreak in France, July to September 2017.
Clémentine Calba,M. Guerbois-Galla,F. Franke,C. Jeannin,M. Auzet-Caillaud,Gilda Grard,Lucette Pigaglio,Anne Decoppet,Joel Weicherding,Marie-Christine Savaill,Manuel Munoz-Riviero,P. Chaud,B. Cadiou,L. Ramalli,Pierre Fournier,Harold Noel,Xavier de Lamballerie,Marie-Claire Paty,Isabelle Leparc-Goffart +18 more
TL;DR: Genomic characterisation identified an East-Central South African (ECSA) lineage strain, probably from the Central African region and carrying an adaptive mutation facilitating transmission by Ae.
Journal ArticleDOI
Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses.
Jelke J. Fros,Gorben P. Pijlman +1 more
TL;DR: The current state of the art of alphavirus host cell shut-off of viral transcription and translation is reviewed, and recent insights in viral subversion of interferon induction and signaling, the unfolded protein response, and stress granule assembly are described.
Journal ArticleDOI
A Neutralizing Monoclonal Antibody Targeting the Acid-Sensitive Region in Chikungunya Virus E2 Protects from Disease
Suganya Selvarajah,Suganya Selvarajah,Nicole R. Sexton,Kristen M. Kahle,Rachel H. Fong,Kimberly-Anne Mattia,Joy Gardner,Kai Lu,Kai Lu,Nathan M. Liss,Nathan M. Liss,Beatriz Salvador,Beatriz Salvador,David F. Tucker,Trevor Barnes,Manu Mabila,Xiangdong Zhou,Giada Rossini,Joseph Rucker,David Avram Sanders,Andreas Suhrbier,Vittorio Sambri,Alain Michault,Marcus O. Muench,Marcus O. Muench,Benjamin J. Doranz,Graham Simmons,Graham Simmons +27 more
TL;DR: The isolation and characterization of two human monoclonal antibodies, C9 and E8, from CHIKV infected and recovered individuals are described, showing that targeting this novel neutralizing epitope in E2 can potently protect both in vitro and in vivo, and it is likely to be an important region both for future antibody and vaccine-based interventions against CHikV.
Journal ArticleDOI
Climatic suitability of Aedes albopictus in Europe referring to climate change projections: comparison of mechanistic and correlative niche modelling approaches.
TL;DR: It is concluded that spatial characteristics such as introduction gateways and dispersal pathways need to be considered in the climatic suitability of the Asian tiger mosquito and laboratory experiments addressing the climatics constraints of the mosquito are required for improved modelling results.
Journal ArticleDOI
Comparative Usutu and West Nile virus transmission potential by local Culex pipiens mosquitoes in north-western Europe
Jelke J. Fros,Pascal Miesen,Chantal B.F. Vogels,Paolo Gaibani,Vittorio Sambri,Byron E. E. Martina,Byron E. E. Martina,Constantianus J. M. Koenraadt,Ronald P. van Rij,Just M. Vlak,Willem Takken,Gorben P. Pijlman +11 more
TL;DR: It is shown for the first time that northwestern European mosquitoes are highly effective vectors for USUV, with infection rates of 11% at 18 °C and 53% at 23 °C, which are comparable with values obtained for WNV.
References
More filters
Journal ArticleDOI
J. Virol. Methods: Corrigendum to “Detection of stylet-borne and circulative potato viruses in aphids by duplex reverse transcription polymerase chain reaction” [59 (1996) 189]
Journal ArticleDOI
Infection with chikungunya virus in Italy: an outbreak in a temperate region
Giovanni Rezza,Loredana Nicoletti,R Angelini,Roberto Romi,A C Finarelli,M. Panning,Paolo Cordioli,Claudia Fortuna,S. Boros,Fabio Magurano,G. Silvi,Paola Angelini,Michele Dottori,Maria Grazia Ciufolini,Giancarlo Majori,Antonio Cassone +15 more
TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.
Journal ArticleDOI
A single mutation in chikungunya virus affects vector specificity and epidemic potential.
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Journal ArticleDOI
Present and future arboviral threats.
TL;DR: Viruses such as dengue (DENV) and chikungunya (CHIKV) that have lost the requirement for enzootic amplification now produce extensive epidemics in tropical urban centers, and climate warming could facilitate the expansion of the distributions of many arboviruses.
Journal ArticleDOI
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
Related Papers (5)
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more