Chikungunya virus, southeastern France.
Marc Grandadam,Valérie Caro,Sébastien Plumet,Jean Michel Thiberge,Yvan Souares,Anna-Bella Failloux,Hugues Tolou,Michel Budelot,Didier Cosserat,Isabelle Leparc-Goffart,Philippe Desprès +10 more
TLDR
Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the chikungunya virus in Europe.Abstract:
In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe.read more
Citations
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Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral
Leen Delang,Nidya Segura Guerrero,Ali Tas,Gilles Querat,Boris Pastorino,Mathy Froeyen,Kai Dallmeier,Dirk Jochmans,Piet Herdewijn,Felio J. Bello,Eric J. Snijder,Xavier de Lamballerie,Byron E. E. Martina,Johan Neyts,Martijn J. van Hemert,Pieter Leyssen +15 more
TL;DR: An important insight is provided into the precise molecular mechanism by which favipiravir exerts its antiviral activity against (alpha)viruses, which may be of help in designing other potent broad-spectrum antivirals.
Journal ArticleDOI
Chikungunya: Its History in Africa and Asia and Its Spread to New Regions in 2013-2014.
TL;DR: The history of CHIKV is discussed as well as its expanding geographic distribution, and the E1 glycoprotein A226V mutation of the East/Central/South Africa genotype conferred enhanced transmission by the A. albopictus mosquito and has been implicated in CHikV's further spread in the last decade.
Journal ArticleDOI
Insecticide resistance status of United States populations of Aedes albopictus and mechanisms involved.
TL;DR: It is found that USA populations are broadly susceptible to currently available larvicides and adulticides, and significant resistance to dichlorodiphenyltrichloroethane (DDT) in two Florida populations and in a New Jersey population is found.
Journal ArticleDOI
A Rainfall- and Temperature-Driven Abundance Model for Aedes albopictus Populations
Annelise Tran,Grégory L'Ambert,Guillaume Lacour,Romain Benoît,Marie Demarchi,Myriam Cros,Priscilla Cailly,Mélaine Aubry-Kientz,Thomas Balenghien,Pauline Ezanno +9 more
TL;DR: A modelling approach to predict mosquito abundance over time, and identify the main determinants of mosquito population dynamics is developed and can be efficiently used as a tool to predict Ae.
Journal ArticleDOI
Reappearance of Chikungunya, Formerly Called Dengue, in the Americas
TL;DR: The syndrome was renamed in the twentieth century after it was shown to differ from dengue, and is now known to be a separate disease.
References
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Infection with chikungunya virus in Italy: an outbreak in a temperate region
Giovanni Rezza,Loredana Nicoletti,R Angelini,Roberto Romi,A C Finarelli,M. Panning,Paolo Cordioli,Claudia Fortuna,S. Boros,Fabio Magurano,G. Silvi,Paola Angelini,Michele Dottori,Maria Grazia Ciufolini,Giancarlo Majori,Antonio Cassone +15 more
TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.
Journal ArticleDOI
A single mutation in chikungunya virus affects vector specificity and epidemic potential.
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Journal ArticleDOI
Present and future arboviral threats.
TL;DR: Viruses such as dengue (DENV) and chikungunya (CHIKV) that have lost the requirement for enzootic amplification now produce extensive epidemics in tropical urban centers, and climate warming could facilitate the expansion of the distributions of many arboviruses.
Journal ArticleDOI
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
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