Chikungunya virus, southeastern France.
Marc Grandadam,Valérie Caro,Sébastien Plumet,Jean Michel Thiberge,Yvan Souares,Anna-Bella Failloux,Hugues Tolou,Michel Budelot,Didier Cosserat,Isabelle Leparc-Goffart,Philippe Desprès +10 more
TLDR
Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the chikungunya virus in Europe.Abstract:
In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe.read more
Citations
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Maiden Outbreak of Chikungunya in Dongguan City, Guangdong Province, China: Epidemiological Characteristics
Zhang Qiaoli,He Jianfeng,Wu De,Wang Zijun,Zhong Xinguang,Zhong Haojie,Ding Fan,Liu Zhiquan,Wang Shi-wen,Huang Zhenyu,Zhang Yonghui,Ke Changwen,Yuan Dakang,Liang Wenjia,Li Deqiong,Chen Pinghua +15 more
TL;DR: Comprehensive control measures based on reducing the density of Aedes mosquitoes were effective in controlling the epidemic and the Breteau index and Mosq-ovitrap index decreased rapidly.
Journal ArticleDOI
A comprehensive immunoinformatics and target site study revealed the corner-stone toward Chikungunya virus treatment.
TL;DR: This computational epitope-based peptide vaccine designing and target site prediction against CHIKV opens up a new horizon which may be the prospective way in Chikungunya virus research.
Journal ArticleDOI
A Phenotypic Assay to Identify Chikungunya Virus Inhibitors Targeting the Nonstructural Protein nsP2
Marianne Lucas-Hourani,Marianne Lucas-Hourani,Alexandru Lupan,Alexandru Lupan,Alexandru Lupan,Philippe Desprès,Sylviane Thoret,Olivier Pamlard,Joëlle Dubois,Catherine Guillou,Frédéric Tangy,Frédéric Tangy,Pierre-Olivier Vidalain,Pierre-Olivier Vidalain,Hélène Munier-Lehmann,Hélène Munier-Lehmann +15 more
TL;DR: A natural compound is identified that partially blocks nsP2 activity and inhibits CHIKV replication in vitro and suggests that similar functional assays could be developed to target other viral proteins mediating a cellular shutoff and identify innovative therapeutic molecules.
Journal ArticleDOI
Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virus
Yuji Wada,Yasuko Orba,Michihito Sasaki,Shintaro Kobayashi,Michael J. Carr,Haruaki Nobori,Akihiko Sato,William W. Hall,Hirofumi Sawa,Hirofumi Sawa +9 more
TL;DR: Results demonstrated that the target site of Compound-A was the M2295 residue in the nonstructural protein 4 (nsP4), which is located in one of the functional domains of RNA-dependent RNA-polymerase (RdRp) which inhibits RdRp function ofCHIKV by using CHIKV replicons.
Journal ArticleDOI
From importation to autochthonous transmission: Drivers of chikungunya and dengue emergence in a temperate area
Frédéric Jourdain,David Roiz,Henriette de Valk,Harold Noel,Grégory L'Ambert,F. Franke,Marie-Claire Paty,A. Guinard,Jean-Claude Desenclos,Benjamin Roche +9 more
TL;DR: A long reporting delay of imported cases to local health authorities is identified as the main driver for autochthonous transmission of dengue and chikungunya in Southern France and can be extrapolated in this area to other viruses such as Zika and yellow fever, which share the same vector.
References
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Infection with chikungunya virus in Italy: an outbreak in a temperate region
Giovanni Rezza,Loredana Nicoletti,R Angelini,Roberto Romi,A C Finarelli,M. Panning,Paolo Cordioli,Claudia Fortuna,S. Boros,Fabio Magurano,G. Silvi,Paola Angelini,Michele Dottori,Maria Grazia Ciufolini,Giancarlo Majori,Antonio Cassone +15 more
TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.
Journal ArticleDOI
A single mutation in chikungunya virus affects vector specificity and epidemic potential.
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Journal ArticleDOI
Present and future arboviral threats.
TL;DR: Viruses such as dengue (DENV) and chikungunya (CHIKV) that have lost the requirement for enzootic amplification now produce extensive epidemics in tropical urban centers, and climate warming could facilitate the expansion of the distributions of many arboviruses.
Journal ArticleDOI
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
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