Journal ArticleDOI
Chlorin e6 conjugated copper sulfide nanoparticles for photodynamic combined photothermal therapy.
Subramaniyan Bharathiraja,Panchanathan Manivasagan,Madhappan Santha Moorthy,Nhat Quang Bui,Kang Dae Lee,Junghwan Oh +5 more
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TLDR
Chlorin e6 (Ce6) conjugated copper sulfide (CuS) nanoparticles (CuE6 NPs) are designed and synthesized and act as a dual-model agent for photodynamic therapy and photothermal therapy and exert a photoacoustic signal for non-invasive imaging of treated cells in tissue-mimicking phantom.About:
This article is published in Photodiagnosis and Photodynamic Therapy.The article was published on 2017-09-01. It has received 34 citations till now. The article focuses on the topics: Photothermal therapy & Photodynamic therapy.read more
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Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes.
TL;DR: The development of diverse biomaterials and nanotechnology allowing copper to be fabricated into diverse structures to realize its theragnostic action is discussed and novel copper complexes and their clinical applications are subsequently described.
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Light-Enhanced O2-Evolving Nanoparticles Boost Photodynamic Therapy To Elicit Antitumor Immunity.
Tingting Wang,Hao Zhang,Yaobao Han,Hanghang Liu,Feng Ren,Jianfeng Zeng,Qiao Sun,Zhen Li,Mingyuan Gao +8 more
TL;DR: It is demonstrated that ultrasmall Cu2- xSe nanoparticle-based nanoplatform offers a promising way to prevent cancer metastasis via immunogenic effects through its excellent PDT performance.
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Nanobiomaterials: from 0D to 3D for tumor therapy and tissue regeneration.
TL;DR: This review systematically review the research progress of nanobiomaterials with varied dimensional structures including 0D, 1D, 2D and 3D, as well as evolutional functions from single tumor therapy to simultaneous tumor therapy and tissue regeneration.
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Photodynamic therapy in head and neck cancer: indications, outcomes, and future prospects.
TL;DR: The value of PDT in specific well-selected head and neck cancer clinical scenarios is well established and experimental findings are promising, maybe eventually leading to optimized results, less side-effects, and more indications.
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Copper sulfide: An emerging adaptable nanoplatform in cancer theranostics.
TL;DR: The pros and cons of using CuS NPs in diagnostics, therapeutics, and theranostics are discussed and the features that render them more advantageous than other established nanoplatforms in cancer management are discussed.
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Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.
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Hydrophilic Cu9S5 Nanocrystals: A Photothermal Agent with a 25.7% Heat Conversion Efficiency for Photothermal Ablation of Cancer Cells in Vivo
Qiwei Tian,Feiran Jiang,Rujia Zou,Qian Liu,Zhigang Chen,Meifang Zhu,Shiping Yang,Jinglong Wang,Jianhua Wang,Junqing Hu +9 more
TL;DR: Under the irradiation of 980 nm laser with the conservative and safe power density over a short period, cancer cells in vivo can be efficiently killed by the photothermal effects of the Cu(9)S(5) NCs.
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Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
TL;DR: This review highlights recent developments aimed at deciphering the molecular interplay between cell death pathways as well as their possible therapeutic exploitation in photosensitized cells.
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Copper sulfide nanoparticles for photothermal ablation of tumor cells
TL;DR: Owing to their unique optical property, small size, low cost of production and low cytotoxicity, CuS nanoparticles are promising new nanomaterials for cancer photothermal ablation therapy.
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Plasmonic Copper Sulfide Nanocrystals Exhibiting Near-Infrared Photothermal and Photodynamic Therapeutic Effects
Shunhao Wang,Andreas Riedinger,Andreas Riedinger,Hongbo Li,Changhui Fu,Huiyu Liu,Linlin Li,Tianlong Liu,Longfei Tan,Markus J. Barthel,Giammarino Pugliese,Francesco De Donato,Marco Scotto d'Abbusco,Xianwei Meng,Liberato Manna,Huan Meng,Teresa Pellegrino +16 more
TL;DR: Interestingly, it is observed that, besides a high PTT efficacy, these copper sulfide NCs additionally possess intrinsic NIR induced photodynamic activity, whereupon they generate high levels of reactive oxygen species.