Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma?
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TLDR
This review article puts emphasis on the description of various bioenergetic types of tumors, from exclusively glycolytic to mainly OXPHOS, and the modulation of both the metabolic apparatus and the modalities of energy substrate utilization according to tumor stage, serial oncogene activation and associated or not fluctuating microenvironmental substrate conditions.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2011-06-01 and is currently open access. It has received 440 citations till now. The article focuses on the topics: Mitochondrial biogenesis & Mitochondrion.read more
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Oxidative stress and cancer: an overview.
TL;DR: The discovery of novel biomarkers that are able to predict the clinical response to pro-oxidant therapies is a crucial challenge to overcome to allow for the personalization of cancer therapies.
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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
Valerie S. LeBleu,Joyce T. O’Connell,Karina N. Gonzalez Herrera,Harriet Wikman,Klaus Pantel,Marcia C. Haigis,Fernanda Machado de Carvalho,Aline Santos Damascena,Ludmilla Thomé Domingos Chinen,Rafael Malagoli Rocha,John M. Asara,Raghu Kalluri +11 more
TL;DR: It is reported that migratory/invasive cancer cells specifically favour mitochondrial respiration and increased ATP production, and mitochondrial biogenesis and respiration induced by PGC-1α are also essential for functional motility of cancer cells and metastasis.
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Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)
TL;DR: This view is challenged by recent investigations which find that the function of mitochondrial OXPHOS in most cancers is intact.
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Energy metabolism in human pluripotent stem cells and their differentiated counterparts.
Sandra Varum,Ana S. B. Rodrigues,Michelle Barbi de Moura,Olga Momčilović,Charles A. Easley,João Ramalho-Santos,Bennett Van Houten,Gerald Schatten +7 more
TL;DR: The results demonstrate that, although the metabolic signature of IPSCs is not identical to that of hESCs, nonetheless they cluster with h ESCs rather than with their somatic counterparts, revealing that human pluripotent cells rely mostly on glycolysis to meet their energy demands.
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Mitochondrial dynamics regulates migration and invasion of breast cancer cells.
Jing Zhao,Juan Zhang,Meifang Yu,Yan Xie,Youguo Huang,Dennis W. Wolff,Peter W. Abel,Yaping Tu +7 more
TL;DR: A marked upregulation of mitochondrial fission protein dynamin-related protein 1 (Drp1) expression is found in human invasive breast carcinoma and metastases to lymph nodes and treatment with a mitochondrial uncoupling agent or adenosine triphosphate synthesis inhibitor reduced lamellipodia formation and decreased breast cancer cell migration and invasion.
References
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The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more
TL;DR: It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.
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Why do cancers have high aerobic glycolysis
TL;DR: In this article, the authors propose that persistent metabolism of glucose to lactate even in aerobic conditions is an adaptation to intermittent hypoxia in pre-malignant lesions, which leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity.
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang,David W. White,Stefan Gross,Bryson D. Bennett,Mark A. Bittinger,Edward M. Driggers,Valeria Fantin,Hyun Gyung Jang,Shengfang Jin,Marie C. Keenan,Kevin Marks,Robert M. Prins,Patrick S. Ward,Katharine E. Yen,Linda M. Liau,Joshua D. Rabinowitz,Lewis C. Cantley,Craig B. Thompson,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Shinsan M. Su +20 more
TL;DR: It is shown that cancer-associated IDH1 mutations result in a new ability of the enzyme to catalyse the NADPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG), and that the excess 2HG which accumulates in vivo contributes to the formation and malignant progression of gliomas.
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.