Clinical characteristics of patients from the worldwide registry on peripartum cardiomyopathy (PPCM)
Karen Sliwa,Karen Sliwa,Alexandre Mebazaa,Denise Hilfiker-Kleiner,Mark C. Petrie,Aldo P. Maggioni,Cécile Laroche,Vera Regitz-Zagrosek,Maria Schaufelberger,Luigi Tavazzi,Peter van der Meer,Jolien W. Roos-Hesselink,Petar M. Seferović,Karin van Spandonck-Zwarts,Amam Mbakwem,Michael Böhm,Frédéric Mouquet,Burkert Pieske,Roger Hall,Piotre Ponikowski,Johann Bauersachs +20 more
TLDR
Disease presentation, co‐morbidities, diagnosis and initial therapeutic management of patients with peripartum cardiomyopathy living in countries belonging to the European Society of Cardiology (ESC) vs. non‐ESC countries are described.Abstract:
Aims
The purpose of this study is to describe disease presentation, co-morbidities, diagnosis and initial therapeutic management of patients with peripartum cardiomyopathy (PPCM) living in countries belonging to the European Society of Cardiology (ESC) vs. non-ESC countries.
Methods and results
Out of 500 patients with PPCM entered by 31 March 2016, we report on data of the first 411 patients with completed case record forms (from 43 countries) entered into this ongoing registry. There were marked differences in socio-demographic parameters such as Human Development Index, GINI index on inequality, and Health Expenditure in PPCM patients from ESC vs. non-ESC countries (P < 0.001 each). Ethnicity was Caucasian (34%), Black African (25.8%), Asian (21.8%), and Middle Eastern backgrounds (16.4%). Despite the huge disparities in socio-demographic factors and ethnic backgrounds, baseline characteristics are remarkably similar. Drug therapy initiated post-partum included ACE inhibitors/ARBs and mineralocorticoid receptor antagonists with identical frequencies in ESC vs. non-ESC countries. However, in non-ESC countries, there was significantly less use of beta-blockers (70.3% vs. 91.9%) and ivabradine (1.4% vs. 17.1%), but more use of diuretics (91.3% vs. 68.8%), digoxin (37.0% vs. 18.0%), and bromocriptine (32.6% vs. 7.1%) (P < 0.001). More patients in non-ESC vs. ESC countries continued to have symptomatic heart failure after 1 month (92.3% vs. 81.3%, P < 0.001). Venous thrombo-embolic events, arterial embolizations, and cerebrovascular accidents were documented in 28 of 411 patients (6.8%). Neonatal death rate was 3.1%.
Conclusion
PPCM occurs in women from different ethnic backgrounds globally. Despite marked differences in socio-economic background, mode of presentation was largely similar. Embolic events and persistent heart failure were common within 1 month post-diagnosis and required intensive, multidisciplinary management.read more
Citations
More filters
Journal ArticleDOI
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
TL;DR: The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update as discussed by the authors .
Journal ArticleDOI
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Vera Regitz-Zagrosek,Jolien W. Roos-Hesselink,Johann Bauersachs,Carina Blomstrom-Lundqvist,Renata Cifkova,Michele De Bonis,Bernard Iung,Mark R. Johnson,Ulrich Kintscher,Peter Kranke,Irene Marthe Lang,João Morais,Petronella G. Pieper,Patrizia Presbitero,Susanna Price,Giuseppe M.C. Rosano,Ute Seeland,Tommaso Simoncini,Lorna Swan,Carole A Warnes +19 more
Journal ArticleDOI
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Paul A. Heidenreich,Biykem Bozkurt,David Aguilar,Larry A. Allen,Joni J. Byun,Monica Colvin,Anita Deswal,Mark H. Drazner,Shannon M. Dunlay,Linda R. Evers,James C. Fang,Savitri Fedson,Gregg C. Fonarow,Salim S. Hayek,Adrian F. Hernandez,Prateeti Khazanie,Michelle M. Kittleson,Christopher S. Lee,Mark S. Link,Carmelo A. Milano,Lorraine C. Nnacheta,Alexander T. Sandhu,Lynne W. Stevenson,Orly Vardeny,Amanda R. Vest,Clyde W. Yancy +25 more
TL;DR: The "2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure" as discussed by the authors provides patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure.
Journal ArticleDOI
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
TL;DR: The 2022 guideline as discussed by the authors provides patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure, with the intent to improve quality of care and align with patients' interests.
Journal ArticleDOI
2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.
Katja Zeppenfeld,Jacob Tfelt-Hansen,Marta de Riva,Bo Gregers Winkel,Elijah R. Behr,Nico A. Blom,Philippe Charron,Domenico Corrado,Nikolaos Dagres,Christian de Chillou,Lars Eckardt,Tim Friede,Kristina H. Haugaa,Mélèze Hocini,Pier D. Lambiase,Eloi Marijon,José L. Merino,Petr Peichl,Silvia G. Priori,Tobias Reichlin,Jeanette Schulz-Menger,Christian Sticherling,Stylianos Tzeis,Axel Verstrael,Maurizio Volterrani +24 more
References
More filters
Journal ArticleDOI
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.
Piotr Ponikowski,Adriaan A. Voors,Stefan D. Anker,Héctor Bueno,John G.F. Cleland,Andrew J.S. Coats,Volkmar Falk,José Ramón González-Juanatey,Veli-Pekka Harjola,Ewa A. Jankowska,Mariell Jessup,Cecilia Linde,Petros Nihoyannopoulos,John Parissis,Burkert Pieske,Jillian P. Riley,Giuseppe M.C. Rosano,Luis M. Ruilope,Frank Ruschitzka,Frans H. Rutten,Peter van der Meer,Gerasimos Filippatos,John J.V. McMurray,Victor Aboyans,Stephan Achenbach,Stefan Agewall,Nawwar Al-Attar,John Atherton,Johann Bauersachs,A. John Camm,Scipione Carerj,Claudio Ceconi,Antonio Coca,Perry M. Elliott,Çetin Erol,Justin A. Ezekowitz,Covadonga Fernández-Golfín,Donna Fitzsimons,Marco Guazzi,Maxime Guenoun,Gerd Hasenfuss,Gerhard Hindricks,Arno W. Hoes,Bernard Iung,Tiny Jaarsma,Paulus Kirchhof,Juhani Knuuti,Philippe Kolh,Stavros Konstantinides,Mitja Lainscak,Patrizio Lancellotti,Gregory Y.H. Lip,Francesco Maisano,Christian Mueller,Mark C. Petrie,Massimo F Piepoli,Silvia G. Priori,Adam Torbicki,Hiroyuki Tsutsui,Dirk J. van Veldhuisen,Stephan Windecker,Clyde W. Yancy,José Luis Zamorano +62 more
TL;DR: Authors/Task Force Members: Piotr Ponikowski* (Chairperson) (Poland), Adriaan A. Voors* (Co-Chair person) (The Netherlands), Stefan D. Anker (Germany), Héctor Bueno (Spain), John G. F. Cleland (UK), Andrew J. S. Coats (UK)
Journal ArticleDOI
ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC).
Vera Regitz-Zagrosek,Carina Blomström Lundqvist,Claudio Borghi,Renata Cifkova,Rafael Ferreira,Jean-Michel Foidart,J Simon R Gibbs,Christa Gohlke-Baerwolf,Bulent Gorenek,Bernard Iung,Mike Kirby,Angela H E M Maas,João Morais,Petros Nihoyannopoulos,Petronella G. Pieper,Patrizia Presbitero,Jolien W. Roos-Hesselink,Maria Schaufelberger,Ute Seeland,Lucia Torracca,Jeroen J. Bax,A Auricchio,Helmut Baumgartner,Claudio Ceconi,Veronica Dean,Christi Deaton,Robert Fagard,Christian Funck-Brentano,David Hasdai,Arno W. Hoes,Juhani Knuuti,Philippe Kolh,Theresa McDonagh,Cyril Moulin,Don Poldermans,Bogdan Alexandru Popescu,Zeljko Reiner,Udo Sechtem,Per Anton Sirnes,Adam Torbicki,Alec Vahanian,Stephan Windecker,Carlos Aguiar,Nawwar Al-Attar,Angeles Alonso Garcia,Anna Antoniou,I M Coman,Uri Elkayam,Miguel Ángel Gómez-Sánchez,Nina Gotcheva,Denise Hilfiker-Kleiner,Róbert Gábor Kiss,Anastasia Kitsiou,Karen T S Konings,Gregory Y.H. Lip,Athanasios J. Manolis,Alexandre Mebaaza,Iveta Mintale,Marie Claude Morice,Barbara J.M. Mulder,Agnes Pasquet,Susanna Price,Silvia G. Priori,Maria J Salvador,Avraham Shotan,Candice K. Silversides,Sven O Skouby,Jörg Ingolf Stein,Pilar Tornos,Niels Vejlstrup,Fiona Walker,Carole A. Warnes +71 more
TL;DR: Recommendations for the prevention and management of venous thrombo-embolism in pregnancy and puerperium and the associated risk groups according to risk factors: definition and preventive measures are presented.
ESC Guidelines on the management of cardiovascular diseases during pregnancy The Task Force on the Management of Cardiovascular Diseases
Carina Blomström Lundqvist,Rafael Ferreira,Jean-Michel Foidart,Joshua D. Simon,R. Gibbs,Angela H.E.M. Maas,Petronella G. Pieper,Jolien W. Roos-Hesselink,Maria Schaufelberger +8 more
TL;DR: In this paper, the authors presented a list of risk factors for venous thrombo-embolism in pregnancy and puerperium in women with heart disease, including the following risk factors: hypertension, congestive heart failure, hypertension, age (>75 years), diabetes, stroke, and atrial septal defect.
Journal ArticleDOI
Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy
Karen Sliwa,Denise Hilfiker-Kleiner,Mark C. Petrie,Alexandre Mebazaa,Burkert Pieske,Eckhart Buchmann,Vera Regitz-Zagrosek,Maria Schaufelberger,Luigi Tavazzi,Dirk J. van Veldhuisen,Hugh Watkins,Ajay J. Shah,Petar M. Seferović,Uri Elkayam,Sabine Pankuweit,Zoltán Papp,Frédéric Mouquet,John J.V. McMurray +17 more
TL;DR: The present position statement offers a state‐of‐the‐art summary of what is known about risk factors for potential pathophysiological mechanisms, clinical presentation of, and diagnosis and management of PPCM.
Journal ArticleDOI
Maternal and Fetal Outcomes of Subsequent Pregnancies in Women with Peripartum Cardiomyopathy
Uri Elkayam,Padmini P. Tummala,Kalpana Rao,Mohammed W. Akhter,Ilyas S. Karaalp,Omar R Wani,Afshan B. Hameed,Israel Gviazda,Avraham Shotan +8 more
TL;DR: Subsequent pregnancy in women with a history of peripartum cardiomyopathy is associated with a significant decrease in left ventricular function and can result in clinical deterioration and even death.
Related Papers (5)
Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy
Karen Sliwa,Denise Hilfiker-Kleiner,Mark C. Petrie,Alexandre Mebazaa,Burkert Pieske,Eckhart Buchmann,Vera Regitz-Zagrosek,Maria Schaufelberger,Luigi Tavazzi,Dirk J. van Veldhuisen,Hugh Watkins,Ajay J. Shah,Petar M. Seferović,Uri Elkayam,Sabine Pankuweit,Zoltán Papp,Frédéric Mouquet,John J.V. McMurray +17 more
Clinical Outcomes for Peripartum Cardiomyopathy in North America Results of the IPAC Study (Investigations of Pregnancy-Associated Cardiomyopathy)
Dennis M. McNamara,Uri Elkayam,Rami Alharethi,Julie B. Damp,Eileen Hsich,Gregory A. Ewald,Kalgi Modi,Jeffrey D. Alexis,Gautam V. Ramani,Marc J. Semigran,Jennifer Haythe,David W. Markham,Josef Marek,John Gorcsan,Wen Chi Wu,Yan Lin,Indrani Halder,Jessica Pisarcik,Leslie T. Cooper,James D. Fett +19 more
A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy
Denise Hilfiker-Kleiner,Karol Kamiński,Edith Podewski,Tomasz A. Bonda,Arnd Schaefer,Karen Sliwa,Olaf Forster,Anja Quint,Ulf Landmesser,Carola Doerries,Maren Luchtefeld,Valeria Poli,Michael D. Schneider,Jean-Luc Balligand,Fanny Desjardins,Aftab A. Ansari,Ingrid Struman,Ngoc Quynh Nhu Nguyen,Nils H. Zschemisch,Gunnar Klein,Gerd Heusch,Rainer Schulz,Andres Hilfiker,Helmut Drexler +23 more
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy
Ian S. Patten,Sarosh Rana,Sajid Shahul,Glenn C. Rowe,Cholsoon Jang,Laura Liu,Michele R. Hacker,Julie S. Rhee,John D. Mitchell,Feroze Mahmood,Philip E. Hess,Caitlin Farrell,Nicole Koulisis,Eliyahu V. Khankin,Suzanne D. Burke,Suzanne D. Burke,I. Tudorache,Johann Bauersachs,Federica del Monte,Denise Hilfiker-Kleiner,S. Ananth Karumanchi,S. Ananth Karumanchi,Zoltan Arany +22 more
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Vera Regitz-Zagrosek,Jolien W. Roos-Hesselink,Johann Bauersachs,Carina Blomstrom-Lundqvist,Renata Cifkova,Michele De Bonis,Bernard Iung,Mark R. Johnson,Ulrich Kintscher,Peter Kranke,Irene Marthe Lang,João Morais,Petronella G. Pieper,Patrizia Presbitero,Susanna Price,Giuseppe M.C. Rosano,Ute Seeland,Tommaso Simoncini,Lorna Swan,Carole A Warnes +19 more