Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
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Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
TL;DR: Serological responses to Severe Acute Respiratory Syndrome Coronavirus 2 nucleocapsid protein and spike glycoprotein and delayed but stronger antibody responses were observed in critical patients.
Journal ArticleDOI
Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis
TL;DR: It is found that both acute cardiac injury and acute kidney injury are highly correlated with an increased risk of COVID-19-related mortality, and there is no correlation between chronic liver disease and increased disease severity.
Journal ArticleDOI
Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial.
Maryam Edalatifard,Maryam Akhtari,Mohammadreza Salehi,Zohre Naderi,Ahmadreza Jamshidi,Shayan Mostafaei,Seyed Reza Najafizadeh,Elham Farhadi,Nooshin Jalili,Masoud Esfahani,Besharat Rahimi,Hossein Kazemzadeh,Maedeh Mahmoodi Aliabadi,Tooba Ghazanfari,Mohammadreza Sattarian,Hourvash Ebrahimi Louyeh,Seyed Reza Raeeskarami,Saeidreza Jamalimoghadamsiahkali,Nasim Khajavirad,Mahdi Mahmoudi,Abdolrahman Rostamian +20 more
TL;DR: Methylprednisolone pulse administration at the beginning of the early pulmonary phase of illness decreased the mortality rate and improved pulmonary involvement, oxygen saturation and inflammatory markers in COVID-19 patients.
Journal ArticleDOI
Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients.
Yifan Meng,Ping Wu,Wanrong Lu,Kui Liu,Ke Ma,Liang Huang,Jiaojiao Cai,Hong Zhang,Yu Qin,Haiying Sun,Wencheng Ding,Lingli Gui,Peng Wu +12 more
TL;DR: Sex is an important biological variable that should be considered in the prevention and treatment of COVID-19, and male patients appeared to be more susceptible to age and comorbidities.
Journal ArticleDOI
Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain.
Juan Berenguer,Pablo Ryan,Jesús Rodríguez-Baño,Inmaculada Jarrín,Jordi Carratalà,Jerónimo Pachón,María Yllescas,J.R. Arriba,E. Aznar Muñoz,P. Gil Divasson,P. González Muñiz,C. Muñoz Aguirre,J. C. López,M. Ramírez-Schacke,Isabel Gutiérrez,F. Tejerina,Teresa Aldámiz-Echevarría,C. Díez,C. Fanciulli,Leire Pérez-Latorre,F. Parras,Pilar Catalán,M.E. García-Leoni,I. Pérez-Tamayo,L. Puente,J. Cedeño,M. Díaz Menéndez,F. de la Calle Prieto,M. Arsuaga Vicente,E. Trigo Esteban,M.D.M. Lago Núñez,R. de Miguel Buckley,J. Cadiñaños Loidi,C. Busca Arenzana,A. Mican,M. Mora Rillo,J.C. Ramos Ramos,B. Loeches Yagüe,J.I. Bernardino de la Serna,J. García Rodríguez,J.R. Arribas López,A. Such Diaz,E. Álvaro Alonso,E. Izquierdo García,J. Torres Macho,G. Cuevas Tascon,J. Troya García,B. Mestre Gómez,E. Jiménez González de Buitrago,I. Fernández Jiménez,A.J. Tebar Martínez,F. Brañas Baztán,J. Valencia de la Rosa,M. Pérez Butragueño,M. Alvarado Blasco,Sepúlveda Berrocal,C. Yera Bergua,P. Toledano Sierra,V. Cano Llorente,S. Zafar Iqubal-Mirza,G. Muñiz,I. Martín Pérez,H. Mozas Moriñigo,A. Alguacil,M.P. García Butenegro,A.I. Peláez Ballesta,E. Morcillo Rodríguez,J. Goikoetxea Agirre,M.J. Blanco Vidal,J. Nieto Arana,M. del Álamo Martínez de Lagos,I.A. Pérez Hernández,I. Pérez Zapata,R. Silvariño Fernández,J. Ugalde Espiñeira,V. Asensi Álvarez,L. Suárez Pérez,S. Suárez Diaz,C. Yllera Gutiérrez,Vicente Boix,M. Díez Martínez,M. Carreres Candela,Cristina Gómez-Ayerbe,J. Sánchez-Lora,J.L. Velasco Garrido,M. López-Jódar,J. Santos González,J. Ruiz Aragón,I. Virto Peña,V. Alende Castro,R. Brea Aparicio,S. Vega Molpeceres,E. Pons Viñas,O. del Río Pérez,S. Valero Rovira,Judit Villar-García,J. Gómez-Junyent,Hernando Knobel,M.C. Cánepa,S. Castañeda Espinosa,L. Sorli Redó,Roberto Güerri-Fernández,Milagro Montero,Juan Pablo Horcajada,E. García Vázquez,E. Moral Escudero,A. Hernández Torres,E. García Almodóvar,C. Sáez Barberá,Z. Karroud,J. Hernández Quero,D. Vinuesa García,J.L. García Fogeda,J.A. Peregrina,M. Novella Mena,C. Hernández Gutiérrez,J. Sanz Moreno,R. Pérez Tanoira,R. Sierra Rodríguez,D. Alonso Menchén,A. Gutiérrez García,A. Arranz Caso,J. Cuadros González,M. Álvarez de Mon Soto,V.F. Díaz de Brito Fernández,M. Sanmarti Vilamala,A. Gabarrell Pascuet,D. Molina Morant,S. España Cueto,J. Cámara Fernández,A. Sabater Gil,L. Muñoz López,P. Sáez Escolano,E. Bejarano Tello,Sempere Alcocer,S. Álvarez Martin,I. de los Santos Gil,Lucio García-Fraile,M. Sampedro Núñez,A. Barrios Blandino,C. Rodríguez Franco,D. Useros Brañas,A. Villa Martí,J. Oliver Ortega,A. Costanza Espiño Álvarez,J. Sanz Sanz,M. Rexach Fumaña,I. Abascal Cambras,A.D.C. Pérez Jaén,C. Sala Jofre,S. Casas Rodríguez,C. Tortajada Alamilla,C. Oltra,M. Masiá Canuto,F. Gutiérrez Rodero,A. Ferrer Ribera,C. Bea Serrano,M. Pedromingo Kus,M.Á. Garcinuño,S. Fiorante,S. Pérez Pinto,P. Hernández Machín,A. Alastrué Violeta,M.C. Fariñas Álvarez,C. González Rico,F. Arnaiz de las Revillas,Jorge Calvo,Mónica Gozalo,F. Mora Gómez,A. Milagro Beamonte,M. Latorre-Millán,A. Rezusta López,A. Martinez Sapiña,Yolanda Meije,A. Duarte Borges,J. Pareja Coca,M. Clemente Presas,J.E. Losa García,A. Vegas Serrano,María Teresa Pérez-Rodríguez,A. Pérez González,M. Belhassen-García,B. Rodríguez-Alonso,A. López-Bernus,Cristina Carbonell,R. Torres Perea,J. Cantón de Seoane,B. Alonso,S.L. Kamal,L. Cajuela,D. Roa,Miguel Cervero,A. Oreja,J.P. Avilés,Leopoldo L. Martin,I. Pelegrín Senent,R. Rouco Esteves Marques,J. Parra Ruiz,V. Ramos Sesma,J. Abadia Otero,J. Salillas Hernando,R. Torres Sánchez del Arco,M. Torralba González de Suso,A. Serrano Martínez,S. Gilaberte Reyzábal,M. Pacheco Martínez-Atienza,M. Liébana Gómez,S. Fernández Rodríguez,Á. Varela Plaza,H. Calvo Sánchez,P. Martínez Martín,P. González-Ruano,E. Malmierca Corral,I. Rábago Lorite,B. Pérez-Monte Mínguez,Á. García Flores,P. Comas Casanova,M. Sirisi,R. Rojas,J.L. Díaz de Tuesta del Arco,R. Figueroa Cerón,A. González Sarria,R. Alemán Valls,M.D.M. Alonso Socas,O. Sanz Peláez,K. Mohamed Ramírez,M. Riera Jaume,H.H. Vilchez,F. Albertí,A.I. Cañabate,V.J. Moreno Cuerda,S. Álvarez Kaelis,B. Álvarez Zapatero,A. García García,E. Isaba Ares,C. Morcate Fernández,A. Pérez Rodríguez,L. Ramos Merino,L. Castelo Corral,M. Rodríguez Mahía,M. González Bardanca,E. Sánchez Vidal,E. Míguez Rey,J. De la Torre Lima,J.M. García de Lomas Guerrero,E. Morte,S. Loscos,A. Camón,L. Gómez García,L. Boix Palop,B. Dietl Gómez-Luengo,I. Pedrola Gorrea,A. Blasco Claramunt,C. López Mestanza,E. Fraile Villarejo,T. Tosco Núñez,M. Aroca Ferri,J.T. Algado Rabasa,A.M. Garijo Saiz,C. Amador Prous,Jesús Rodríguez Baño,Pilar Retamar,Adoración Valiente,Luis Eduardo López-Cortés,J. Sojo,Belén Gutiérrez-Gutiérrez,José Bravo-Ferrer,Elena Salamanca,Z.R. Palacios,Patricia Pérez-Palacios,E. Peral,J.A. Pérez de León,J. Sánchez-Gómez,L. Marín-Barrera,D. García-Jiménez,Gabriela Abelenda-Alonso,Carmen Ardanuy,A. Bergas,Guillermo Cuervo,M.Á. Domínguez,Miguel Fernández-Huerta,Carlota Gudiol,Laia Lorenzo-Esteller,Jordi Niubó,S. Pérez-Recio,Daniel Podzamczer,Miquel Pujol,Alexander Rombauts,N. Trullen,M. Salavert Lletí,I. Castro Hernández,A. Hernández Belmonte,R. Martínez Goñi,M. Navarro Vilasaró,S. Calzado Isbert,M. Cervantes García,A. Gomila Grange,O. Gasch Blasi,M.L. Machado Sicilia,E. Van den Eynde Otero,L. Falgueras López,M.D.C. Navarro Sáez,Eduardo Martínez,M.Á. Marcos,Maria Mar Mosquera,José L. Blanco,Montse Laguno,Jhon Rojas,Ana González-Cordón,Alexy Inciarte,Berta Torres,L. De la Mora,Alex Soriano,O. Martínez Macias,V. Pérez Doñate,A. Cabello Úbeda,N. Carrasco Antón,B. Álvarez Álvarez,E. Petkova Saiz,M. Górgolas Hernández-Mora,L. Prieto Pérez,I. Carrillo Acosta,S. Heili Frades,F. Villar Álvarez,R. Fernández Roblas,J.M. Milicua Muñoz,V. Fernández Espinilla,C.J. Dueñas Gutiérrez,C. Hernán García,F. González-Romo,P. Merino Amador,A. Rueda López,J. Martínez Jordán,S. Medrano Pardo,I. Díaz de la Torre,Y. Posada Franco,Alberto Delgado-Iribarren,J. López-Contreras González,Pablo Alonso,V. Pomar Solchaga,N. Rabella García,N. Benito Hernández,P. Domingo Pedrol,X. Bonfill Cosp,R. Padrós Selma,M. Puig Campmany,J. Mancebo Cortés,M. Gurguí Ferrer,M. Íñigo Pestaña,A. Pérez García,P. Sorní Moreno,N. Izko Gartzia,F.J. Membrillo de Novales,M. Simón Sacristán,M. Zamora Cintas,Y. Martínez Martínez,P. Fernández-González,F. Alcántara Nicolás,A. Aguirre Vila-Cora,E. López Tizón,Germán Ramírez-Olivencia,M. Estébanez Muñoz,E. Sáez de Adana Arróniz,J. Portu Zapirain,J.C. Gainzarain Arana,Z. Ortiz de Zárate Ibarra,M.Á. Moran Rodríguez,A. Canut Blasco,S. Hernáez Crespo,L. Balerdi Sarasola,C. Morales García,M. Corral Saracho,Z. Valcarce González,N. Arenal Andrés,R.E. Rodríguez Tarazona,L. Iglesias Llorente,B. Loureiro Rodríguez,A. Sánchez Montalvá,J. Espinosa Pereiro,Benito Almirante,M Miarons,J. Sellarés,María Nieves Larrosa,S. García,B. Marzo,M. Villamarín,Nuria Fernández,C. Pérez-Jorge Peremarch,E. Resino Foz,A. Espigares Correa,T. Álvarez de Espejo Montiel,I. Navas Clemente,M.I. Quijano Contreras,L.A. Nieto Fernández del Campo,G. Jiménez Álvarez,M. Guillamón Sánchez,J.J. García García,C. Muñoz Hornero,A. Mariño Callejo,N. Valcarce Pardeiro,A. Smithson Amat,C. Chico Chumillas,A. Sánchez Serrano,E.P. García Villalba,I. Jiménez Martínez,G. Estrada Fernández,M. Lorén Vargas,N. Parra Arribas,C. Martínez Cilleros,A. Villasante de la Puente,T. García Delange,M.J. Ruiz Rodríguez,M. Robledo del Prado,J.C. Abad Almendro,J.R. Muñoz del Rey,M. Jiménez Álvaro,J. Coy Coy,I. Poquet Catala,M. Santos Peña,V. Naranjo Velasco,T. Manso Gómez,D. Quilez Ágreda,G. Barbeito Castiñeiras,M.J. Domínguez Santalla,L. Mao Martín,R. Alonso Navarro,J.D. Ampuero Martinich,R. Barrós González,Galindo Martín,L. Herrera Pacheco,R. Martínez Avilés,S. Rodrigo González,C.M. Rodríguez Leal,E.M. Romay Lema,R. Suárez Gil,M. Ibarguren Pinilla,J.M. Marimón Ortiz de Zárate,L. Vidaur Tello,X. Kortajarena Urkola,M. García Gómez,A. Aranguren Arostegui,M. Álvarez de Castro,C.M. Martínez Mateu,F. Rodríguez Gómez,F. Muñoz Beamud,E. Chamarro Martí,M. Cardona Rivera,I. Zakariya-Yousef Breval,M. Rico Rodríguez,J. Llenas García,M.C. Sánchez Arenas,A. Fernández Cruz,J. Calderón Parra,M. López Dosil,A. Ramos Martínez,E. Múñez Rubio,A. Callejas Díaz,J.M. Vázquez Comendador,I. Diego Yagüe,E. Expósito Palomo,J. Anel Pedroche,R. Álvarez Franco,L. Fernández de Orueta,R. Vates Gómez,A.F. Cardona Arias,P. Marguenda Contreras,Gabriel Gaspar Alonso-Vega,E.M. Aranda Rife,B. Martínez Cifre,D. Roger Zapata,I. Martín Rubio,A. Barbosa Ventura,I. Piñero,A. Bahamonde Carrasco,P. Runza Buznego,E. Talavera García,M. Lamata Subero,A. Urrutia Losada,L. Arteche Eguizabal,E. Delgado Sánchez,V. Molina Peinado,S. Caro Bragado,G. Domínguez de Pablos,C. Roldán Fontana,C. Herrero Rodríguez,L. Force Sanmartín,R. Aranega,A. Mera Fidalgo,M.R. Toda Savall,N. Merchante Gutiérrez,E.M. León Jiménez,J.L. Del Pozo León,J. Serralta Buades,G.G. Cabrera Tejada,Mario Fernández-Ruiz,José María Aguado,G. Maestro de la Calle,José Miguel Cisneros,Manuela Aguilar-Guisado,T. Aldabó,Avilés,Carlos Eduardo da Silveira Bueno,E. Cordero-Matía,A. Escoresca,L. Gálvez-Benítez,C. Infante,G. Martín,Julia Praena,Cristina Roca,C. Salamanca,Alejandro Suárez-Benjumea,Pilar Vizcarra,Carmen Quereda,M.J. Rodriguez Dominguez,Francesca Gioia,F. Norman,S. Del Campo,R. Cantón Moreno,A. Oteo Revuelta José,P. Santibáñez Sáenz,C. Cervera Acedo,C. Ruiz Martínez,J.R. Blanco Ramos,J.M. Azcona Gutiérrez,C. García García,J. Alba Fernández,V. Ibarra Cucalón,M. San Franco,L. Metola Sacristán,H. Meijide Míguez,S. Paulos Viñas,J. Menéndez,P. Villares Fernández,L. Montes Andújar,Á. Navarro Batet,A. Ferrer Santolaria,M.D.L.L. Padilla Salazar,L. Abella Vázquez,M. Hayek Peraza,A. García Pardo,C. Hernández Carballo,A.J. Ruiz Fernández,I. Barrio López,A. Martakoush,A. Rojas-Vieyra,S. García Calvo,M. Villarreal García-Lomas,M. Vizcaíno Callejón,M.P. García García,A. Lérida Urteaga,N. Carrasco Fons,B. María Sanjuan,L. Martín González,C. Sanz Zamudio,Belén Alejos,C. Moreno,Marta Rava,C. Iniesta,Rebeca Izquierdo,I. Suárez-García,Alberto Diaz,M. Ruiz-Alguero,V. Hernando +562 more
TL;DR: The findings provide comprehensive information about characteristics and complications of severe COVID-19 and may help to identify patients at a higher risk of death.
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