Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
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Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes.
Christina Price,Christina Price,Frederick L. Altice,Yu Shyr,Alan Koff,Lauren Pischel,George Goshua,Marwan M. Azar,Dayna McManus,Sheau-Chiann Chen,Shana E. Gleeson,Clemente J. Britto,Veronica Azmy,Kelsey Kaman,David C. Gaston,Matthew A. Davis,Trisha Burrello,Zachary Harris,Merceditas Villanueva,Lydia Aoun-Barakat,Insoo Kang,Stuart Seropian,Geoffrey L. Chupp,Richard Bucala,Naftali Kaminski,Alfred Ian Lee,Patricia LoRusso,Jeffrey E Topal,Charles S. Dela Cruz,Maricar Malinis +29 more
TL;DR: Tocilizumab, an IL-6 receptor antagonist, can be used to treat cytokine release syndrome (CRS), with observed improvements in a coronavirus disease 2019 (COVID-19) case series as mentioned in this paper.
Journal ArticleDOI
COVID-19 and the role of chronic inflammation in patients with obesity.
TL;DR: Analyzing a group of metabolic ill patients with obesity (EOSS 2 and 3), the authors found an increased interleukin-6 and linear regression analysis showed a positive correlation with C-reactive protein (CRP) and waist-to-hip-ratio (WHR) and Physicians should be aware of these findings in patients with COVID-19 infection.
Journal ArticleDOI
A report from the Brescia Renal COVID Task Force on the clinical characteristics and short-term outcome of hemodialysis patients with SARS-CoV-2 infection.
Federico Alberici,Elisa Delbarba,Chiara Manenti,Laura Econimo,Francesca Valerio,Alessandra Pola,Camilla Maffei,Stefano Possenti,Bernardo Lucca,Roberta Cortinovis,Vincenzo Terlizzi,Mattia Zappa,Chiara Saccà,Elena Pezzini,Eleonora Calcaterra,Paola Piarulli,Alice Guerini,Francesca Boni,Agnese Gallico,Alberto Mucchetti,Stefania Affatato,Sergio Bove,Martina Bracchi,Ester Maria Costantino,Roberto Zubani,Corrado Camerini,Paola Gaggia,Ezio Movilli,Nicola Bossini,Mario Gaggiotti,Francesco Scolari +30 more
TL;DR: In a population of hemodialysis patients with SARS-CoV-2 infection, a wide range of disease severity is documented, and the risk of ARDS and death is significant for patients requiring hospital admission at disease diagnosis.
Journal ArticleDOI
COVID-19 and Sex Differences: Mechanisms and Biomarkers.
Tu Haitao,Jane V. Vermunt,Jithma P. Abeykoon,Ranine Ghamrawi,Madugodaralalage D. S. K. Gunaratne,Muthuvel Jayachandran,Kavita Narang,Santosh Parashuram,Sonja Suvakov,Vesna D. Garovic +9 more
TL;DR: There is the need for larger studies with sex-specific reporting and robust analyses to elucidate how sex modifies cellular and molecular pathways associated with SARS-CoV-2 to improve interpretation of biomarkers and clinical management of COVID-19 patients by facilitating a personalized medical approach to risk stratification, prevention, and treatment.
Journal ArticleDOI
Severe covid-19 pneumonia: pathogenesis and clinical management.
TL;DR: In this article, high flow nasal cannula (HFNC) was used to avoid intubation in acute respiratory distress syndrome (CARDS) patients with severe SARS CoV-2 infection.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
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