Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
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Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD
Narjes Saheb Sharif-Askari,Fatemeh Saheb Sharif-Askari,Mashael Alabed,Mohamed Hani Temsah,Saba Al Heialy,Saba Al Heialy,Qutayba Hamid,Qutayba Hamid,Rabih Halwani,Rabih Halwani +9 more
TL;DR: The results suggest that the observed difference in COVID-19 severity between children and adults could, in part, be attributed to the difference in ACE2 and TMPRSS2 airways tissue expression levels.
Journal ArticleDOI
Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19.
Yun Xie,Song Cao,Hui Dong,Qingyun Li,Erzhen Chen,Wenkai Zhang,Luyu Yang,Shouzhi Fu,Ruilan Wang +8 more
TL;DR: Initiation of IVIG as adjuvant treatment for COVID-19 pneumonia within 48 h of admission to the ICU can reduce the use of mechanical ventilation and hospital length of stay and length ofStay in ICU.
Journal ArticleDOI
Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study.
Emanuel Della-Torre,Corrado Campochiaro,Giulio Cavalli,Giacomo De Luca,Angela Napolitano,Salvatore La Marca,Nicola Boffini,Valentina Da Prat,Gaetano Di Terlizzi,Marco Lanzillotta,Patrizia Rovere Querini,Annalisa Ruggeri,Giovanni Landoni,Moreno Tresoldi,Fabio Ciceri,Alberto Zangrillo,Francesco De Cobelli,Lorenzo Dagna +17 more
TL;DR: Overall clinical improvement and mortality in patients with severe COVID-19 pneumonia were not significantly different between sarilumab and standard of care and Sariluab was associated with faster recovery in a subset of patients showing minor lung consolidation at baseline.
Journal ArticleDOI
Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU
Damien Contou,Aurore Claudinon,Olivier Pajot,Maïté Micaëlo,Pascale Longuet Flandre,Marie Dubert,Radj Cally,Elsa Logre,Megan Fraissé,Hervé Mentec,Gaëtan Plantefève +10 more
TL;DR: A 28% rate of bacterial co-infection at ICU admission of patients with severe SARSCoV-2 pneumonia is reported, mostly related to Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae and Enterobacteriaceae.
Journal ArticleDOI
Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19.
Yaqing Zhou,Tao Han,Jiaxin Chen,Can Hou,Lei Hua,Shu He,Yi Guo,Sheng Zhang,Yanjun Wang,Jinxia Yuan,Chenhui Zhao,Jing Zhang,Qiao-Wei Jia,Xiangrong Zuo,Jinhai Li,Liansheng Wang,Quan Cao,Enzhi Jia +17 more
TL;DR: Autoimmune phenomena exist in COVID‐19 subjects, and the present results provide the rationale for a strategy of preventing immune dysfunction and optimal immunosuppressive therapy.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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