Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
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Pathological Role of Angiotensin II in Severe COVID-19
TL;DR: The complex clinical picture of patients with severe complications of COVID-19 is triggered by the various effects of highly expressed angiotensin II on vasculopathy, coagulopathy, and inflammation.
Posted ContentDOI
The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera
Raveen Rathnasinghe,Sonia Jangra,Anastasija Cupic,Carles Martínez-Romero,Lubbertus C. F. Mulder,Thomas Kehrer,Soner Yildiz,Angela Choi,Ignacio Mena,Jana De Vrieze,Sadaf Aslam,Daniel Stadlbauer,David A. Meekins,Chester McDowell,Velmurugan Balaraman,Juergen A. Richt,Bruno G. De Geest,Lisa Miorin,Florian Krammer,Viviana Simon,Adolfo García-Sastre,Michael Schotsaert +21 more
TL;DR: In this paper, a mouse-adapted SARS-CoV-2 was serial passed through a clinical virus isolate in the lungs of mice and then used low doses of this virus in mouse models for advanced age, diabetes and obesity.
Journal ArticleDOI
Clinical Characteristics of Elderly Patients with COVID-19 in Hunan Province, China: A Multicenter, Retrospective Study.
Ting Guo,Qinxue Shen,Wei Guo,Wenlong He,Jinhua Li,Yi Zhang,Yunnian Wang,Zhiguo Zhou,Dingding Deng,Xiaoli Ouyang,Zhi Xiang,Minyan Jiang,Minyong Liang,Peng Huang,Zaimei Peng,Xudong Xiang,Wenlong Liu,Hong Luo,Ping Chen,Hong Peng +19 more
TL;DR: Elderly patients usually have chronic medical illness and are likely to have a severe or critically severe condition and could show atypical symptoms without fever or cough and multiple organ dysfunction.
Journal ArticleDOI
Tocilizumab and steroid treatment in patients with COVID-19 pneumonia.
Malgorzata Mikulska,Laura Ambra Nicolini,Alessio Signori,Antonio Di Biagio,Chiara Sepulcri,Chiara Russo,Silvia Dettori,Marco Berruti,Maria Pia Sormani,Daniele Roberto Giacobbe,Antonio Vena,Andrea De Maria,Chiara Dentone,Lucia Taramasso,Michele Mirabella,Laura Magnasco,Sara Mora,Emanuele Delfino,Federica Toscanini,Elisa Balletto,A. Alessandrini,Federico Baldi,Federica Briano,Marco Camera,Ferdinando Dodi,Antonio Ferrazin,Laura Labate,Giovanni Mazzarello,Rachele Pincino,Federica Portunato,Stefania Tutino,Emanuela Barisione,Bianca Bruzzone,Andrea Orsi,Eva Schenone,Nirmala Rosseti,Elisabetta Sasso,Giorgio Da Rin,Paolo Pelosi,Sabrina Beltramini,Mauro Giacomini,Giancarlo Icardi,Angelo Gratarola,Matteo Bassetti +43 more
TL;DR: Early adjunctive treatment with tocilizumab, methylprednisolone or both may improve outcomes in non-intubated patients with COVID-19 pneumonia.
Journal ArticleDOI
The Inflammasome in Times of COVID-19.
Juan Carlos de Rivero Vaccari,W. Dalton Dietrich,Robert W. Keane,Juan Pablo de Rivero Vaccari +3 more
TL;DR: The literature regarding the mechanism of inflammasome activation by CoV infection, the role of the inflamMASome in ARDS, ventilator-induced lung injury (VILI), and Disseminated Intravascular Coagulation (DIC) are reviewed as well as the potential mechanism by which the infammasome may contribute to the damaging effects of inflammation in the cardiac, renal, digestive, and nervous systems in COVID-19 patients are reviewed.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
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