Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
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Systematic review with meta-analysis: liver manifestations and outcomes in COVID-19.
Anand V. Kulkarni,Pramod Kumar,Harsh Vardhan Tevethia,Madhumita Premkumar,Juan Pablo Arab,Roberto Candia,Rupjyoti Talukdar,Mithun Sharma,Xiaolong Qi,Padaki Nagaraja Rao,Duvvuru Nageshwar Reddy +10 more
TL;DR: The incidence of elevated liver chemistries and the presence of pre‐existing chronic liver disease (CLD) have been variably reported in COVID‐19.
Journal ArticleDOI
Emergency surgery during the COVID-19 pandemic: what you need to know for practice.
B. De Simone,Elie Chouillard,S. Di Saverio,Leonardo Pagani,Massimo Sartelli,W.L. Biffl,Federico Coccolini,A Pieri,Mansoor Khan,Giuseppe Borzellino,Fabio Cesare Campanile,Luca Ansaloni,Fausto Catena +12 more
TL;DR: The aim was to review the most current data on COVID-19 to provide essential suggestions on how to manage the acute abdomen during the pandemic.
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Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers.
TL;DR: Special attention is definitely required in patients with CO VID-19 with associated comorbidities including hypertension, diabetes and established CVD, given that COVID-19 expresses to tissues through the receptor of angiotensin converting enzyme-2.
Journal ArticleDOI
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.
TL;DR: This review focuses on the main pathophysiological aspects of ACE2, ADAM17, and TMPRSS2 host proteins in COVID-19, and discusses a possible mechanism to explain the deleterious effect of ADAM 17 and TM PRSS2 over-activation in the CO VID-19 outcome.
Journal ArticleDOI
SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment
Chien-Ting Wu,Peter V. Lidsky,Yinghong Xiao,Ivan T. Lee,Ran Cheng,Tsuguhisa Nakayama,Sizun Jiang,Janos Demeter,Romina J. Bevacqua,Charles A. Chang,Robert L. Whitener,Anna K. Stalder,Bokai Zhu,Han Chen,Yury Goltsev,Alexandar Tzankov,Jayakar V. Nayak,Garry P. Nolan,Matthias S. Matter,Raul Andino,Peter K. Jackson +20 more
TL;DR: In this paper, the SARS-CoV-2 infection attenuates pancreatic insulin levels and secretion and induces β cell apoptosis, each rescued by NRP1 inhibition.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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