Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
Citations
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Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study.
Anahita Rouzé,Ignacio Martin-Loeches,Pedro Póvoa,Pedro Póvoa,Demosthenes Makris,Antonio Artigas,Mathilde Bouchereau,Fabien Lambiotte,Matthieu Metzelard,Pierre Cuchet,Claire Boulle Geronimi,Marie Labruyere,Fabienne Tamion,Martine Nyunga,Charles-Edouard Luyt,Julien Labreuche,Olivier Pouly,Justine Bardin,Anastasia Saade,Pierre Asfar,Jean-Luc Baudel,Alexandra Beurton,Denis Garot,Iliana Ioannidou,Louis Kreitmann,Jean-François Llitjos,Eleni Magira,Bruno Mégarbane,David Meguerditchian,Edgar Moglia,Armand Mekontso-Dessap,Jean Reignier,Matthieu Turpin,Alexandre Pierre,Gaëtan Plantefève,Christophe Vinsonneau,Pierre-Edouard Floch,Nicolas Weiss,Adrian Ceccato,Antoni Torres,Alain Duhamel,Saad Nseir +41 more
TL;DR: In this article, the authors determined the relationship between SARS-CoV-2 pneumonia, as compared to influenza pneumonia or no viral infection, and the incidence of ventilator-associated lower respiratory tract infections (VA-LRTI).
Journal ArticleDOI
Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study).
Shiv Kumar Sarin,Ashok Choudhury,George K. K. Lau,Ming-Hua Zheng,Dong Ji,Sherief Abd-Elsalam,J.S. Hwang,Xiaolong Qi,Ian Homer Y. Cua,Jeong Ill Suh,Jun Gi Park,Opass Putcharoen,Apichat Kaewdech,Teerha Piratvisuth,Sombat Treeprasertsuk,Soo-Young Park,Salisa Wejnaruemarn,Diana A. Payawal,Oidov Baatarkhuu,Sang Hoon Ahn,Chang Dong Yeo,Uzziel Romar Alonzo,Tserendorj Chinbayar,Imelda Maria Loho,Osamu Yokosuka,Wasim Jafri,S. G. Tan,Lau Ing Soo,Tawesak Tanwandee,Rino Alvani Gani,Lovkesh Anand,Eslam Saber Esmail,Mai Khalaf,Shahinul Alam,Chun-Yu Lin,Wan-Long Chuang,Arvinder S. Soin,Hitendra K. Garg,Kemal Fariz Kalista,Badamnachin Batsukh,Hery Djagat Purnomo,Vijay Pal Dara,Pravin Rathi,Mamun Al Mahtab,Akash Shukla,Manoj K. Sharma,Masao Omata +46 more
TL;DR: SARS-Cov-2 infection causes significant liver injury in CLD patients, decompensating one fifth of cirrhosis, and worsening the clinical status of the already decompensated, which makes the patients with diabetes and obesity more vulnerable and should be closely monitored.
Journal ArticleDOI
AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL 1 High-Risk Genotype.
Huijuan Wu,Huijuan Wu,Christopher P. Larsen,Cesar F. Hernandez-Arroyo,M. Mohamed,Tiffany Caza,Moh’d A. Sharshir,Asim Chughtai,Liping Xie,Juan M Gimenez,T. Sandow,Mark A Lusco,Haichun Yang,Ellen Acheampong,Ivy A. Rosales,Robert B. Colvin,Agnes B. Fogo,Juan Carlos Q. Velez,Juan Carlos Q. Velez +18 more
TL;DR: Collapsing glomerulopathy in black patients with COVID-19 was associated with high-risk APOL1 variants, suggesting a possible alternative mechanism: a "two-hit" combination of genetic predisposition and cytokine-mediated host response to SARS-CoV-2 infection.
Journal ArticleDOI
Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.
Man Lung Yeung,Jade Lee Lee Teng,Lilong Jia,Chaoyu Zhang,Chengxi Huang,Jian-Piao Cai,Runhong Zhou,Kwok-Hung Chan,Kwok-Hung Chan,Hanjun Zhao,Lin Zhu,Kam-Leung Siu,Sin-Yee Fung,Susan Yung,Tak Mao Chan,Kelvin K. W. To,Jasper Fuk-Woo Chan,Zongwei Cai,Susanna K. P. Lau,Zhiwei Chen,Dong-Yan Jin,Patrick C. Y. Woo,Kwok-Yung Yuen,Kwok-Yung Yuen +23 more
TL;DR: In this paper, the authors performed a genome-wide RNAi screen and identified virus dependency factors (VDFs) which play regulatory roles in biological pathways linked to clinical manifestations of SARS-CoV-2 infection.
Journal ArticleDOI
COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic's Impact in Type 1 and Type 2 Diabetes.
Justin M. Gregory,James C. Slaughter,Sara H Duffus,T. Jordan Smith,Lauren M. LeStourgeon,Sarah S. Jaser,Allison B. McCoy,James M. Luther,Erin R. Giovannetti,Schafer Boeder,Jeremy Pettus,Daniel J. Moore +11 more
TL;DR: Diabetes status, both type 1 and type 2, independently increases the adverse impacts of COVID-19, indicating an urgent and continued need to mitigate severe acute respiratory syndrome coronavirus 2 infection risk in this community.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
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