Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
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Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry.
Ryan P. Barbaro,Graeme MacLaren,Philip S. Boonstra,Theodore J. Iwashyna,Arthur S. Slutsky,Eddy Fan,Robert H. Bartlett,Joseph E. Tonna,Robert Hyslop,Jeffrey J Fanning,Peter Rycus,Steve J Hyer,Marc Anders,Cara Agerstrand,K. Hryniewicz,Rodrigo Diaz,Roberto Lorusso,Alain Combes,Daniel Brodie +18 more
TL;DR: In patients with COVID-19 who received ECMO, both estimated mortality 90 days after ECMO and mortality in those with a final disposition of death or hospital discharge were less than 40%.
Journal ArticleDOI
Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial.
Olivier Hermine,Olivier Hermine,Xavier Mariette,Pierre-Louis Tharaux,Matthieu Resche-Rigon,Raphaël Porcher,Philippe Ravaud +6 more
TL;DR: In this randomized clinical trial of patients with COVID-19 and pneumonia requiring oxygen support but not admitted to the intensive care unit, TCZ did not reduce WHO-CPS scores lower than 5 at day 4 but might have reduced the risk of NIV, MV, or death by day 14, and no difference on day 28 mortality was found.
Journal ArticleDOI
Laboratory diagnosis of emerging human coronavirus infections - the state of the art.
TL;DR: The current laboratory methods available for testing coronaviruses are reviewed by focusing on the coronavirus disease 2019 (COVID-19) outbreak going on in Wuhan, with a focus on the SARS-CoV-2 infections.
Journal ArticleDOI
Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study.
Bertrand Cariou,Samy Hadjadj,Matthieu Wargny,Matthieu Pichelin,Abdallah Al-Salameh,Ingrid Allix,Coralie Amadou,Gwénaëlle Arnault,Florence Baudoux,Bernard Bauduceau,Sophie Borot,Muriel Bourgeon-Ghittori,Olivier Bourron,David Boutoille,Claude Chaumeil,Emmanuel Cosson,Sandrine Coudol,Patrice Darmon,Emmanuel Disse,Amélie Ducet-Boiffard,Bénédicte Gaborit,Michael Joubert,Véronique Kerlan,Bruno Laviolle,Lucien Marchand,Laurent Meyer,Louis Potier,Gaëtan Prévost,Jean-Pierre Riveline,Jean-Pierre Riveline,René Robert,Pierre Jean Saulnier,Ariane Sultan,Jean François Thébaut,Charles Thivolet,Blandine Tramunt,Camille Vatier,Ronan Roussel,Jean François Gautier,Pierre Gourdy +39 more
TL;DR: BMI, but not long-term glucose control, was positively and independently associated with tracheal intubation and/or death within 7 days of admission in people with diabetes hospitalised for COVID-19.
Journal ArticleDOI
Comprehensive mapping of immune perturbations associated with severe COVID-19.
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Laura A. Vella,Oliva Kuthuru,Sokratis A. Apostolidis,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,E. John Wherry,Nuala J. Meyer,Michael R. Betts +33 more
TL;DR: The neutrophil to lymphocyte ratio is found to be a prognostic biomarker of disease severity and organ failure and broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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