Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
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Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis.
Ren Mao,Yun Qiu,Jin Shen He,Jin Yu Tan,Xuehua Li,Jie Liang,Jun Shen,Liang Ru Zhu,Yan Chen,Marietta Iacucci,Siew C. Ng,Subrata Ghosh,Min Hu Chen +12 more
TL;DR: Patients in Hubei province, where the initial COVID-19 outbreak occurred, were more likely to present with abnormal liver functions (p<0·0001) compared with those outside of Hubeo and those with non-severe disease.
Journal ArticleDOI
Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors.
Huan Han,Qingfeng Ma,Cong Li,Rui Liu,Li Zhao,Wei Wang,Ping-an Zhang,Xinghui Liu,Guosheng Gao,Fang Liu,Yingan Jiang,Xiaoming Cheng,Chengliang Zhu,Yuchen Xia +13 more
TL;DR: The result indicated higher levels of cytokine storm is associated with more severe disease development andIL-6 and IL-10 can be used as predictors for fast diagnosis of patients with higher risk of disease deterioration.
Journal ArticleDOI
Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units.
Lara S. Shekerdemian,Nabihah R. Mahmood,Katie K. Wolfe,Becky J. Riggs,Catherine E. Ross,Christine A. McKiernan,Sabrina M. Heidemann,Lawrence C. Kleinman,Anita Sen,Mark W. Hall,Margaret A. Priestley,John K. McGuire,Konstantinos Boukas,Matthew Sharron,Jeffrey P. Burns +14 more
TL;DR: The burden of COVID-19 infection in North American PICUs is described and confirmed that severe illness in children is significant but far less frequent than in adults and prehospital comorbidities appear to be an important factor in children.
Journal ArticleDOI
Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19.
Wentao Ni,Xiuwen Yang,Deqing Yang,Jing Bao,Ran Li,Yongjiu Xiao,Chang Hou,Haibin Wang,Jie Liu,Donghong Yang,Yu Xu,Zhaolong Cao,Zhancheng Gao +12 more
TL;DR: The SARS-CoV-2 spike glycoprotein, which binds to ACE2, is a potential target for developing specific drugs, antibodies, and vaccines and Restoring the balance between the RAS and ACE2/angiotensin-(1–7)/MAS may help attenuate organ injuries.
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Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy.
TL;DR: Data from previous coronavirus infections such as severe acute respiratory syndrome and Middle East respiratory syndrome, as well as emerging data from the COVID-19 pandemic, suggest there could be substantial fibrotic consequences following SARS-CoV-2 infection.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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