Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
Reads0
Chats0
TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
Citations
More filters
Journal ArticleDOI
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial.
Mayla Gabriela Silva Borba,Fernando Fonseca Almeida Val,Vanderson de Souza Sampaio,Márcia A. A. Alexandre,Gisely Cardoso de Melo,Marcelo A M Brito,Maria Paula Gomes Mourão,Jose Diego Brito-Sousa,Djane Clarys Baia-da-Silva,Marcus Vinitius de Farias Guerra,Ludhmila Abrahão Hajjar,R. Pinto,Antônio Alcirley da Silva Balieiro,Antonio G. Pacheco,James D. Santos,Felipe Gomes Naveca,Mariana Simão Xavier,André M. Siqueira,Alexandre Vargas Schwarzbold,Julio Croda,Julio Croda,Maurício Lacerda Nogueira,Gustavo Adolfo Sierra Romero,Quique Bassat,Cor Jesus Fernandes Fontes,Bernardino Cláudio de Albuquerque,Cláudio Tadeu Daniel-Ribeiro,Wuelton Marcelo Monteiro,Marcus Lacerda +28 more
TL;DR: The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir.
Journal ArticleDOI
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).
Waleed Alhazzani,Morten Hylander Møller,Yaseen M. Arabi,Mark Loeb,Michelle Ng Gong,Eddy Fan,Simon Oczkowski,Mitchell M. Levy,Lennie P. G. Derde,Amy L. Dzierba,Bin Du,Michael S. Aboodi,Hannah Wunsch,Maurizio Cecconi,Younsuck Koh,Daniel S. Chertow,Kathryn Maitland,Fayez Alshamsi,Emilie P. Belley-Côté,Massimiliano Greco,Matthew Laundy,Jill S. Morgan,Jozef Kesecioglu,Allison McGeer,Leonard A. Mermel,Manoj J. Mammen,Paul E. Alexander,Amy S. Arrington,John Centofanti,Giuseppe Citerio,Bandar Baw,Bandar Baw,Ziad A. Memish,Naomi E Hammond,Frederick G Hayden,Laura Evans,Andrew Rhodes +36 more
TL;DR: A panel of 36 experts from 12 countries issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19, and assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation approach.
Journal ArticleDOI
Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis.
Leiwen Fu,Bingyi Wang,Tanwei Yuan,Xiaoting Chen,Yunlong Ao,Thomas Fitzpatrick,Peiyang Li,Yiguo Zhou,Yi-Fan Lin,Qibin Duan,Ganfeng Luo,Song Fan,Yong Lu,Anping Feng,Yuewei Zhan,Bowen Liang,Weiping Cai,Lin Zhang,Xiangjun Du,Linghua Li,Yuelong Shu,Huachun Zou +21 more
TL;DR: The majority of COVID-19 cases are symptomatic with a moderate CFR, and patients living in Wuhan, older patients, and those with medical comorbidities tend to have more severe clinical symptoms and higher CFR.
Journal ArticleDOI
Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study.
Giulio Cavalli,Giacomo De Luca,Corrado Campochiaro,Emanuel Della-Torre,Marco Ripa,Diana Canetti,Chiara Oltolini,Barbara Castiglioni,Chiara Tassan Din,Nicola Boffini,Alessandro Tomelleri,Nicola Farina,Annalisa Ruggeri,Patrizia Rovere-Querini,Giuseppe Di Lucca,S. Martinenghi,Raffaella Scotti,Moreno Tresoldi,Fabio Ciceri,Giovanni Landoni,Alberto Zangrillo,Paolo Scarpellini,Lorenzo Dagna +22 more
TL;DR: In this retrospective cohort study of patients with COVID-19 and ARDS managed with non-invasive ventilation outside of the ICU, treatment with high-dose anakinra was safe and associated with clinical improvement in 72% of patients.
Journal ArticleDOI
Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19.
Ahmet Kursat Azkur,Mübeccel Akdis,Dilek Azkur,Milena Sokolowska,Willem van de Veen,Marie-Charlotte Brüggen,Liam O'Mahony,Ya-dong Gao,Kari C. Nadeau,Cezmi A. Akdis +9 more
TL;DR: Understanding of the immune response and immunopathological changes in patients linked to deteriorating clinical conditions such as cytokine storm, acute respiratory distress syndrome, autopsy findings and changes in acute‐phase reactants, and serum biochemistry in COVID‐19 is improved.
References
More filters
Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
Related Papers (5)
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more