Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
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TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2020-05-01 and is currently open access. It has received 7787 citations till now. The article focuses on the topics: Pneumonia & ARDS.read more
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A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
Shi Hui Sun,Qi Chen,Hong Jing Gu,Guan Yang,Yan Xiao Wang,Xing Yao Huang,Su Su Liu,Na Na Zhang,Xiaofeng Li,Rui Xiong,Yan Guo,Yong Qiang Deng,Weijin Huang,Quan Liu,Quan Ming Liu,Yue Lei Shen,Yong Zhou,Xiao Yang,Tong Yan Zhao,Chang Fa Fan,Yu Sen Zhou,Cheng-Feng Qin,You Chun Wang +22 more
TL;DR: This animal model, generated using CRISPR/Cas9 knock-in technology, provides a useful tool for studying SARS-CoV-2 transmission and pathogenesis, and evaluating COVID-19 vaccines and therapeutics.
Journal ArticleDOI
Risk Factors of Fatal Outcome in Hospitalized Subjects With Coronavirus Disease 2019 From a Nationwide Analysis in China.
Ruchong Chen,Wenhua Liang,Mei Jiang,Wei-jie Guan,Chen Zhan,Tao Wang,Chun-Li Tang,Ling Sang,Jiaxing Liu,Zhengyi Ni,Yu Hu,Lei Liu,Hong Shan,Chunliang Lei,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Xiaoqing Liu,Linling Cheng,Feng Ye,Jinping Zheng,Nuofu Zhang,Yimin Li,Jianxing He,Shiyue Li,Nanshan Zhong +36 more
TL;DR: The proposed nomogram accurately predict clinical outcomes of patients with COVID-19 based on individual characteristics and has sufficient discriminatory power with the C-index of 0.91.
Journal ArticleDOI
Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center's observational study.
TL;DR: In this series of severe pediatric patients in Wuhan, polypnea was the most common symptom, followed by fever and cough, and a cytokine storm was found in these patients, which appeared more serious in critically ill patients.
Journal ArticleDOI
Prediction for Progression Risk in Patients With COVID-19 Pneumonia: The CALL Score.
Dong Ji,Dawei Zhang,Jing Xu,Zhu Chen,Tieniu Yang,Peng Zhao,Guofeng Chen,Gregory Cheng,Yudong Wang,Jingfeng Bi,Lin Tan,George Lau,Enqiang Qin +12 more
TL;DR: Using the CALL score model, clinicians can improve the therapeutic effect and reduce the mortality of COVID-19 with more accurate and reasonable resolutions on medical resources.
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COVID-19: Immunology and treatment options.
Susanna Felsenstein,Jenny A. Herbert,Paul S. McNamara,Christian M. Hedrich,Christian M. Hedrich +4 more
TL;DR: Understanding immune evasion strategies of SARS-CoV2 and the resulting delayed massive immune response will result in the identification of biomarkers that predict outcomes as well as phenotype and disease stage specific treatments that will likely include both antiviral and immune modulating agents.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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