Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1994-11-01. It has received 678 citations till now. The article focuses on the topics: Glucocorticoid receptor & Apparent mineralocorticoid excess syndrome.read more
Citations
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Journal ArticleDOI
The Effect of Amiloride and Sodium Chloride on Rat Renal and Hepatic 11β‐Hydroxysteroid Dehydrogenase Activities
TL;DR: The effect of treating rats for 4 days with the potassium sparing diuretic amiloride or with 3% NaCl in drinking water on renal and hepatic microsomal oxidative and reductive 11 beta-hydroxysteroid dehydrogenase activities and immunoreactive 11 beta
Journal ArticleDOI
Citosine-Adenine-Repeat Microsatellite of 11β-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children.
Carolina Valdivia,Cristian A. Carvajal,Carmen Campino,Carmen Campino,Fidel Allende,Alejandro Martinez-Aguayo,Rene Baudrand,Andrea Vecchiola,Andrea Vecchiola,Carlos F. Lagos,Alejandra Tapia-Castillo,Cristobal A. Fuentes,Cristobal A. Fuentes,Marlene Aglony,Sandra Solari,Alexis M. Kalergis,Hernán García,Gareth I. Owen,Carlos E. Fardella,Carlos E. Fardella +19 more
TL;DR: The CA-repeat length did not influence BP levels or serum F/E ratios in pediatric subjects, however, the serumF/E ratio was associated with BP, suggesting a role of 11βHSD2 in mineralocorticoid hypertension.
Journal ArticleDOI
Regulation of 11β‐Hydroxysteroid Dehydrogenase Type II Expression in the Renal Epithelial Cells
TL;DR: It is concluded that in renal epithelial cells in primary culture, stimulation of PKA pathway results in the induction of 11βHSD2 both at a specific mRNA and at a protein level and that this effect is markedly reduced by activation of PKC pathway.
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Myometrial expression of 11 beta-hydroxysteroid dehydrogenase type 2 in rat pregnancy.
TL;DR: It is suggested that local levels of active glucocorticoid in the myometrium are determined by the net effects of myometrial 11 beta-HSD-1 and -2 expression across pregnancy.
Journal ArticleDOI
Sodium Balance and Hypertension: Rare Genetic Disorders Expose Pathogenic Mechanisms
TL;DR: The discovery of the molecular mechanisms involved in the pathogenesis of some rare forms of hypertension, i.e., Liddle’s syndrome, glucocorticoid-remediable hypertension, and apparent mineraloc Corticoid excess are presented.
References
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Journal ArticleDOI
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
TL;DR: The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
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LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
C. R. W. Edwards,D. Burt,M.A. Mcintyre,E.R. de Kloet,Paul M. Stewart,Lawrence P. Brett,W. Sutanto,Carl Monder +7 more
TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
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A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
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Anti-escherichia coli alpha-haemolysin in control and patient sera
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Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
TL;DR: It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.