Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1994-11-01. It has received 678 citations till now. The article focuses on the topics: Glucocorticoid receptor & Apparent mineralocorticoid excess syndrome.read more
Citations
More filters
Journal ArticleDOI
Interconversion of cortisol and cortisone in the baboon placenta at midgestation : Expression of 11β-hydroxysteroid dehydrogenase type 1 messenger RNA
TL;DR: It is suggested that the net formation of F from E during transuterine passage in vivo at this stage of gestation results from the 11beta-HSD-1 in the syncytiotrophoblast cells of the baboon placenta.
Journal ArticleDOI
Localisation of 11β-Hydroxysteroid Dehydrogenase Type 2 in Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory Neurones of the Rat Supraoptic and Paraventricular Nuclei.
TL;DR: Findings suggest that MNCs in the SON and PVN are aldosterone‐sensitive neurones, and 11β‐HSD2 mRNAs from cDNA libraries derived from single identified MNCS are detected.
Journal ArticleDOI
11β-hydroxysteroid dehydrogenase type 2 in zebra finch brain and peripheral tissues
TL;DR: The wide distribution of 11betaHSD2 and MR throughout the songbird brain suggests that concentrations of glucocorticoids may be locally regulated in brain to modulate their actions on MR and possibly also glucOCorticoid receptors (GR).
Journal ArticleDOI
Mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type II expression in renal cell neoplasms: a tissue microarray and quantitative RT-PCR study.
Evgeny Yakirevich,David J. Morris,David J. Morris,Rosemarie Tavares,Rosemarie Tavares,Patricia A. Meitner,Patricia A. Meitner,Mirna Lechpammer,Mirna Lechpammer,Lelia Noble,Lelia Noble,Angela de Rodriguez,Angela de Rodriguez,Celso E. Gomez-Sanchez,Celso E. Gomez-Sanchez,Li Juan Wang,Li Juan Wang,Edmond Sabo,Edmond Sabo,Ronald A. DeLellis,Ronald A. DeLellis,Murray B. Resnick,Murray B. Resnick +22 more
TL;DR: This study indicates MR and 11β-HSD2 are both sensitive and specific markers of the distal nephron and its related neoplasms (CHRCC and OC) and CHRCC showed higher expression of MR and 12β- HSD2, as compared with OC.
Journal ArticleDOI
Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11β-hydroxysteroid dehydrogenase type 2 in the rat placenta
TL;DR: The data indicate that placental barrier function mediated by 11 beta-HSD2 might be considerably impaired by the antenatal therapy with DXM and BTM, and the discrepancy between expressional and functional studies suggests that sole analysis of expressional changes of 11 Beta-HSSD2 at mRNA and/or protein levels cannot convincingly predict the role of GC treatment on 11beta- HSD2 function in the placental Barrier.
References
More filters
Journal ArticleDOI
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
TL;DR: The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
Journal ArticleDOI
LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
C. R. W. Edwards,D. Burt,M.A. Mcintyre,E.R. de Kloet,Paul M. Stewart,Lawrence P. Brett,W. Sutanto,Carl Monder +7 more
TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
Journal ArticleDOI
A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
Journal ArticleDOI
Anti-escherichia coli alpha-haemolysin in control and patient sera
Journal ArticleDOI
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
TL;DR: It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.