Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1994-11-01. It has received 678 citations till now. The article focuses on the topics: Glucocorticoid receptor & Apparent mineralocorticoid excess syndrome.read more
Citations
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Journal ArticleDOI
Isoforms of 11β-hydroxysteroid dehydrogenase in human granulosa-lutein cells
A E Michael,Marianthi Evagelatou,Dean P. Norgate,Rebecca J. Clarke,Joseph W. Antoniw,Brian A. Stedman,Alex Brennan,Rachel Welsby,Iwona Bujalska,Paul Stewart,Brian A. Cooke +10 more
TL;DR: It is concluded that human granulosa-lutein cells express both type 1 11βSD and a novel isoform of this enzyme, which is NADP+-dependent, does not metabolize dexamethasone and is resistant to end-product inhibition.
Journal ArticleDOI
Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11β-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-κB homodimers and Egr-1
TL;DR: It is demonstrated that transgenic mice overexpressing TNF‐α have decreased mRNA abundance and activity of 11β‐HSD2 in kidney tissue, indicating that this effect may occur also in vivo.
Journal ArticleDOI
Spatial and Temporal Patterns of Expression of 11β-Hydroxysteroid Dehydrogenase Types 1 and 2 Messenger RNA and Glucocorticoid Receptor Protein in the Murine Placenta and Uterus During Late Pregnancy
TL;DR: The present study demonstrates for the first time remarkable spatial and temporal patterns of expression of 11 β-HSD1 and 11β- HSD2 and GR in the murine placenta and uterus and highlights the intricate control of not only transplacental passage of maternal glucocorticoid to the fetus but also local glucoc Corticoid action during late pregnancy.
Journal ArticleDOI
Evolutionary analysis of 11β‐hydroxysteroid dehydrogenase‐type 1, ‐type 2, ‐type 3 and 17β‐hydroxysteroid dehydrogenase‐type 2 in fish
TL;DR: Unexpectedly, a search of the Takifugu, Tetraodon and medaka genomes only found an ortholog to 11β‐HSD2 and none to 17β‐ HSD2, while the zebrafish genome contains orthologs of both enzymes.
Journal ArticleDOI
Effect of prenatal glucocorticoid treatment on size at birth among infants born at term gestation.
TL;DR: Prenatal treatment with a single course of GCs was associated with a reduction in size at birth among infants born at term gestation, and this effect cannot be explained by differences in fetal size before treatment or exposure to preterm labor.
References
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Journal ArticleDOI
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
TL;DR: The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
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LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
C. R. W. Edwards,D. Burt,M.A. Mcintyre,E.R. de Kloet,Paul M. Stewart,Lawrence P. Brett,W. Sutanto,Carl Monder +7 more
TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
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A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
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Anti-escherichia coli alpha-haemolysin in control and patient sera
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Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
TL;DR: It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.