Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1994-11-01. It has received 678 citations till now. The article focuses on the topics: Glucocorticoid receptor & Apparent mineralocorticoid excess syndrome.read more
Citations
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Pastis and hypertension—what is the molecular basis?
Felix J. Frey,Paolo Ferrari +1 more
TL;DR: The discovery of the value of liquorice — previously marketed as than a direct effect of glycyrrhetinic acid on renal carbenoxolone, an oleandane derivative of glucose retention and potassium excretion — in the treatment of peptic ulcer allowed researchers to establish its adverse effect on salt and water metabolism.
Journal ArticleDOI
Metabolomics analysis of follicular fluid coupled with oocyte aspiration reveals importance of glucocorticoids in primate periovulatory follicle competency.
Sweta Ravisankar,Sweta Ravisankar,Kelsey E. Brooks,Melinda J. Murphy,Nash Redmayne,Junghyun Ryu,Jason M. Kinchen,Shawn L. Chavez,Shawn L. Chavez,Jon D. Hennebold,Jon D. Hennebold +10 more
TL;DR: In this article, the intrafollicular environment affects oocyte competency, 74 individual rhesus macaque follicles were aspirated and the corresponding oocytes classified as failed to cleave, cleaved but arrested prior to blastulation, or those that formed blastocysts following in vitro fertilization.
Journal ArticleDOI
Longer HSD11B2 CA-repeat in impaired glucose tolerance and type 2 diabetes.
Tomoatsu Mune,Tetsuya Suwa,Hiroyuki Morita,Yukinori Isomura,Nobuki Takada,Yoritsuna Yamamoto,Makoto Hayashi,Noriyoshi Yamakita,Akihiko Sasaki,Noriyuki Takeda,Jun Takeda,Perrin C. White,Kohei Kaku +12 more
TL;DR: In this paper, the association of HSD11B2 variant with glucose homeostasis was investigated, with significant linear trends between the repeat length and the phenotype fraction, and the total CA-repeat length was negatively correlated with fasting insulin and HOMA-β.
Journal ArticleDOI
Angiotensin administration stimulates renal 11|[beta]|-hydroxysteroid dehydrogenase activity in healthy men
Michiel N. Kerstens,Frank G.H. van der Kleij,Arnold H. Boonstra,Wim J. Sluiter,Jan C. van der Molen,Gerjan Navis,Robin P. F. Dullaart +6 more
TL;DR: It is suggested that acute angiotensin administration stimulates the activity of 11 beta HSD type 2 in human kidney and might exert a dual effect on the mineralocorticoid receptor.
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Expression of human kidney 11β-hydroxysteroid dehydrogenase (11-HSD2) in bacteria
TL;DR: The N-terminal hydrophobic domains are essential for complete activity of 11-HSD2 but association with an intact cell membrane is not, whereas wild-type activity was almost completely sedimented following 100,000g centrifugation, 10-30% of total activity of 12- HSD2/His remained in the supernatant.
References
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Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
TL;DR: The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
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LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
C. R. W. Edwards,D. Burt,M.A. Mcintyre,E.R. de Kloet,Paul M. Stewart,Lawrence P. Brett,W. Sutanto,Carl Monder +7 more
TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
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A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
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Anti-escherichia coli alpha-haemolysin in control and patient sera
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Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
TL;DR: It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.