Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1994-11-01. It has received 678 citations till now. The article focuses on the topics: Glucocorticoid receptor & Apparent mineralocorticoid excess syndrome.read more
Citations
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Journal ArticleDOI
Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in αT3-1 and LβT2 Gonadotroph Cells.
TL;DR: Gonadotroph 11βHSD enzyme activity can act to regulate local glucocorticoid availability to mediate the influence of the HPA axis on gonadotrophic function.
Journal ArticleDOI
ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure.
Janet H Leung,Omar Bayomy,Omar Bayomy,Istvan Bonyhay,Istvan Bonyhay,Johanna Celli,Jeffrey White,Roy Freeman,Roy Freeman,Gail K. Adler,Gail K. Adler +10 more
TL;DR: Investigate the role of the adrenocorticotropin hormone (ACTH)-adrenal axis in decreasing BRS and the possibility that hypoglycemia-induced increases in ACTH may contribute to the cardiovascular component of HAAF.
Journal ArticleDOI
The hypertensiogenetic steroid 19-nor-progesterone does not influence cortisol inactivation by 11beta-hydroxysteroid dehydrogenase type 2
TL;DR: In conclusion, 19-nor-P did not inhibit human 11β-HSD2 and seems not to be involved in human hypertension, but may be converted by extra-adrenal tissues into 19- Nor-deoxycorticosterone (DOC) or 19-Nor-cortICosterone, which are potent mineralocorticoids and may be involved In the pathogenesis of hypertension during pregnancy.
Journal ArticleDOI
Hipertensión arterial mineralocorticoidea
E B Carlos Fardella,Cristian A. Carvajal,Carmen Campino,Alejandra Tapia,Hernán García,Alejandro Martinez-Aguayo +5 more
TL;DR: De otra parte, defectos congenitos o adquiridos en the enzima 11β-Hidroxiesteroide deshidrogenasa tipo 2 resultan en una ineficiente inactivacion de cortisol a cortisona favoreciendo la aparicion de hipertension por activacion del receptor mineralocorticoideo.
Book ChapterDOI
Molecular Genomics of Mineralocorticoid Action
Peter J. Fuller,Morag J. Young +1 more
TL;DR: The mineralocorticoid receptor is a member of the nuclear receptor superfamily that acts as a ligand-dependent transcription factor that mediates its effects not only through a transcriptional mechanism but also through nongenomic mechanisms and perhaps through transrepression.
References
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Journal ArticleDOI
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
TL;DR: The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
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LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
C. R. W. Edwards,D. Burt,M.A. Mcintyre,E.R. de Kloet,Paul M. Stewart,Lawrence P. Brett,W. Sutanto,Carl Monder +7 more
TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
Journal ArticleDOI
A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
Journal ArticleDOI
Anti-escherichia coli alpha-haemolysin in control and patient sera
Journal ArticleDOI
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
TL;DR: It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.