Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1994-11-01. It has received 678 citations till now. The article focuses on the topics: Glucocorticoid receptor & Apparent mineralocorticoid excess syndrome.read more
Citations
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Cortisol synthesis in epidermis is induced by IL-1 and tissue injury.
Sasa Vukelic,Olivera Stojadinovic,Irena Pastar,Morgan Rabach,Agata Krzyzanowska,Elizabeth Lebrun,Stephen C. Davis,Sydney R. Resnik,Harold Brem,Marjana Tomic-Canic +9 more
TL;DR: The novel finding that both keratinocytes in vitro and epidermis in vivo synthesize cortisol and how this synthesis regulates wound healing is reported, providing the evidence that modulation of cortisol synthesis in epidersmis may be an important regulatory mechanism during wound healing.
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Fetal Glucocorticoid Exposure Is Associated with Preadolescent Brain Development
Elysia Poggi Davis,Elysia Poggi Davis,Curt A. Sandman,Claudia Buss,Deborah A. Wing,Kevin Head +5 more
TL;DR: Fetal exposure to synthetic glucocorticoids has neurologic consequences that persist for at least 6 to 10 years, and the data indicating that the rACC is associated with affective problems in conjunction with evidence that this region is involved in affective disorders raise the possibility that glucOCorticoid-associated neurologic changes increase vulnerability to mental health problems.
Journal ArticleDOI
A Switch in Dehydrogenase to Reductase Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 upon Differentiation of Human Omental Adipose Stromal Cells
TL;DR: In intact, undifferentiated om ASCs, 11 beta-HSD1 acts primarily as a dehydrogenase, but in mature adipocytes oxoreductase activity predominates, and it is postulate that 11beta- HSD1 activity in uncommitted ASCs may facilitate proliferation rather than differentiation.
Journal ArticleDOI
Modulation of 11β-Hydroxysteroid Dehydrogenase Isozymes by Growth Hormone and Insulin-Like Growth Factor: In Vivo and In Vitro Studies1
Jasbir S. Moore,John P. Monson,Gregory Kaltsas,P. Putignano,Peter J. Wood,Michael C. Sheppard,G. M. Besser,Norman F. Taylor,Paul M. Stewart +8 more
TL;DR: There was a significant alteration in the normal set-point of F to E interconversion toward E, and the fall in the urinary tetrahydrocortisols/tetrahydocortisone ratio (THF+allo-THF/THE) bu...
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The role of 11β-hydroxysteroid dehydrogenase type 2 in human hypertension.
TL;DR: Findings indicate that variants of the HSD11B2 gene may contribute to the enhanced blood pressure response to salt and possibly to hypertension in humans.
References
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Journal ArticleDOI
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
TL;DR: The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
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LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
C. R. W. Edwards,D. Burt,M.A. Mcintyre,E.R. de Kloet,Paul M. Stewart,Lawrence P. Brett,W. Sutanto,Carl Monder +7 more
TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
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A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
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Anti-escherichia coli alpha-haemolysin in control and patient sera
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Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
TL;DR: It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.