Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1994-11-01. It has received 678 citations till now. The article focuses on the topics: Glucocorticoid receptor & Apparent mineralocorticoid excess syndrome.read more
Citations
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Journal ArticleDOI
Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Yuping Zhu,Steven H. Olson,Donald J. Graham,Gool F. Patel,Anne Hermanowski-Vosatka,Steven S. Mundt,Kashmira Shah,Marty S. Springer,Rolf Thieringer,Samuel D. Wright,Jianying Xiao,Hratch J. Zokian,Jasminka Dragovic,James M. Balkovec +13 more
TL;DR: 3-(Phenylcyclobutyl)-1,2,4-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and fluorine substitution of the cyclobutane ring improved the pharmacokinetic profile significantly.
Journal ArticleDOI
A Mutation in the Cofactor-Binding Domain of 11β-Hydroxysteroid Dehydrogenase Type 2 Associated with Mineralocorticoid Hypertension1
Alex Odermatt,Bernhard Dick,Peter Arnold,Tanja Zaehner,Valmai Plueschke,Margarita N. Deregibus,Horacio Repetto,Brigitte M. Frey,Felix J. Frey,Paolo Ferrari +9 more
TL;DR: Two siblings, 1 and 2 yr old, who were diagnosed with hypokalemic hypertension and low plasma aldosterone and renin levels, indicating mineralocorticoid hypertension are described, providing evidence for a role of Glu(115) in determining cofactor-binding specificity of 11betaHSD2 and emphasize the importance of structure-function analysis to elucidate the molecular mechanism of AME.
Journal ArticleDOI
Molecular analysis of 11β-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess
TL;DR: There was no significant correlation between 11-HSD activity, mRNA levels, and either fetal or placental weight, and it was found that the biochemical phenotype of AME is largely determined by genotype.
Journal ArticleDOI
Age-related changes in 11β-hydroxysteroid dehydrogenase type 2 activity in normotensive subjects.
Carmen Campino,Alejandro Martinez-Aguayo,Rene Baudrand,Cristian A. Carvajal,Marlene Aglony,Hernán García,Oslando Padilla,Alexis M. Kalergis,Carlos E. Fardella +8 more
TL;DR: C cortisol and the cortisol/cortisone ratio increased with age, but cortisone decreased, suggesting a decrease in 11β-HSD2 activity, and it is suggested that the cortisol-mediated activation of the mineralocorticoid receptor may explain the blood pressure increase in elderly subjects.
Journal ArticleDOI
The Sp1 Transcription Factor Is Crucial for the Expression of 11β-Hydroxysteroid Dehydrogenase Type 2 in Human Placental Trophoblasts
Jianneng Li,Yuchun Ge,Zhen Yang,Chunming Guo,Tao Duan,Leslie Myatt,Haiyan Guan,Kaiping Yang,Kang Sun +8 more
TL;DR: 11β-HSD2 induction upon syncytialization is at least in part due to the increased expression of Sp1 upon activation of the cAMP pathway rather than the differential methylation of the HSD11B2 promoter.
References
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Journal ArticleDOI
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
TL;DR: The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
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LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
C. R. W. Edwards,D. Burt,M.A. Mcintyre,E.R. de Kloet,Paul M. Stewart,Lawrence P. Brett,W. Sutanto,Carl Monder +7 more
TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
Journal ArticleDOI
A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
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Anti-escherichia coli alpha-haemolysin in control and patient sera
Journal ArticleDOI
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
TL;DR: It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.