Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1994-11-01. It has received 678 citations till now. The article focuses on the topics: Glucocorticoid receptor & Apparent mineralocorticoid excess syndrome.read more
Citations
More filters
Journal ArticleDOI
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
TL;DR: Understanding steroidogenesis is of fundamental importance to understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiological homeostasis.
Journal ArticleDOI
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
Jeremy W. Tomlinson,Elizabeth A. Walker,Iwona J. Bujalska,Nicole Draper,Gareth G. Lavery,Mark S. Cooper,Martin Hewison,Paul M. Stewart +7 more
TL;DR: It is speculated that hexose-6-phosphate dehydrogenase activity and therefore reduced nicotinamide-adenine dinucleotide phosphate supply may be crucial in determining the directionality of 11beta-HSD1 activity.
Journal ArticleDOI
Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids
TL;DR: This review has summarized the multiple endogenous and exogenous factors that have been shown to be involved in this signaling cascade and, thus, to alter glucocorticoid sensitivity.
Journal ArticleDOI
Prenatal Stress, Glucocorticoids and the Programming of the Brain
Leonie Welberg,Jonathan R. Seckl +1 more
TL;DR: The data suggest that key targets for programming include glucocorticoid receptor gene expression and the corticotrophin‐releasing hormone system, and that approaches to minimize or reverse the consequences of such early life events may have therapeutic importance.
Journal ArticleDOI
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
Yuri Kotelevtsev,Megan C. Holmes,Ann Burchell,Pamela Houston,Dieter Schmoll,Pauline Jamieson,Ruth Best,Roger W. Brown,Christopher R. W. Edwards,Jonathan R. Seckl,John J. Mullins +10 more
TL;DR: Attenuation of hepatic 11beta-HSD-1 may provide a novel approach to the regulation of gluconeogenesis, which involves regenerating active glucocorticoids from circulating inert 11-keto forms in specific tissues, notably the liver.
References
More filters
Journal ArticleDOI
11 beta-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells.
TL;DR: It is concluded that through reduction of the levels of inhibitory glucocorticoids, 11HSD has a novel role among Leydig cell steroid-metabolizing enzymes in the regulation of T production.
Journal ArticleDOI
Type 2 11 beta-hydroxysteroid dehydrogenase in human fetal tissues.
P M Stewart,B A Murry,J I Mason +2 more
TL;DR: 11 beta-HSD activity in fetal tissues is mediated by the type 2, high affinity, isoform, and the widespread distribution of this novel isoform suggests that it may play an important role in fetal development.
Journal ArticleDOI
llβ-Hydroxysteroid Dehydrogenase Activity in the Renal Target Cells of Aldosterone*
TL;DR: Whether metabolism of CS occurs in the renal target cells of aldosterone, i.e. in cortical collecting duct cells, and if it does so, whether this activity is sufficient to reduce intracellular CS levels to allow binding of a Aldosterone to the mineralocorticoid receptor.
Journal ArticleDOI
Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.
TL;DR: The crucial role played by an 11 beta hydroxysteroid dehydrogenase in the local protection of type I receptors in mineralocorticoid selective tissues is supported by evidence of 20 reductase activity which uses the reduced cofactor at the expense of the color reaction.
Journal ArticleDOI
Polyoma and hamster papovavirus large T antigen-mediated replication of expression shuttle vectors in Chinese hamster ovary cells
Mike Heffernan,James W. Dennis +1 more
TL;DR: Results show that expression-cloning in CHO cells expressing either polyoma virus or hamster papovavirus LT antigens is possible using either the CDM8 or the pMH vectors, respectively.