Co-regulation and function of FOXM1 / RHNO1 bidirectional genes in cancer.
Carter J. Barger,Linda Chee,Mustafa Albahrani,Catalina Munoz-Trujillo,Lidia Boghean,Connor Branick,Kunle Odunsi,Ronny Drapkin,Lee Zou,Adam R. Karpf +9 more
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TLDR
This paper showed that RHNO1 and FOXM1 are head-to-head (i.e., bidirectional) genes (BDG) regulated by a BDP (named F/R-BDP), which is a potential therapeutic approach for ovarian and other cancers.Abstract:
The FOXM1 transcription factor is an oncoprotein and a top biomarker of poor prognosis in human cancer. Overexpression and activation of FOXM1 is frequent in high-grade serous carcinoma (HGSC), the most common and lethal form of human ovarian cancer, and is linked to copy number gains at chromosome 12p13.33. We show that FOXM1 is co-amplified and co-expressed with RHNO1, a gene involved in the ATR-Chk1 signaling pathway that functions in the DNA replication stress response. We demonstrate that FOXM1 and RHNO1 are head-to-head (i.e., bidirectional) genes (BDG) regulated by a bidirectional promoter (BDP) (named F/R-BDP). FOXM1 and RHNO1 each promote oncogenic phenotypes in HGSC cells, including clonogenic growth, DNA homologous recombination repair, and poly-ADP ribosylase inhibitor resistance. FOXM1 and RHNO1 are one of the first examples of oncogenic BDG, and therapeutic targeting of FOXM1/RHNO1 BDG is a potential therapeutic approach for ovarian and other cancers.read more
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SOCS7/HuR/FOXM1 signaling axis inhibited high-grade serous ovarian carcinoma progression
TL;DR: In this article , the authors investigated the functions and mechanisms of suppressors of cytokine signaling 7 (SOCS7) in HGSOC and found that SOCS7 acted as a suppressor by inhibiting cancer cell viability and tumor growth in vivo.
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Bidirectional promoters: an enigmatic genome architecture and their roles in cancers.
Sheikh Shafin Ahmad,Nure Sharaf Nower Samia,Auroni Semonti Khan,Rafeed Rahman Turjya,Abdullah-Al-Kamran Khan +4 more
TL;DR: In this article, the characteristic features of bidirectional promoters alongside their transcriptional regulations are discussed, and the association of these enigmatic genomic elements in different cancers is investigated, and it is shown that these genomic elements might contribute towards the immune regulation in tumor microenvironment.
Posted ContentDOI
FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1
TL;DR: In this article , the authors analyzed chromatin accessibility in human dermal fibroblasts (HDFs) from neonatal and octogenarian individuals and found that TEAD4 and FOXM1 share a conserved transcriptional regulatory landscape controlled by an age-dependent enhancer that closes with aging and drives senescence when deleted.
Journal ArticleDOI
RHNO1 disruption inhibits cell proliferation and induces mitochondrial apoptosis via PI3K/Akt pathway in hepatocellular carcinoma.
TL;DR: In this article , the role and molecular mechanisms of RHNO1 in HCC remain largely elusive, however, the authors imply that RHNO 1 is elevated in the HCC tumor tissues and that high expression of RH NO 1 predicts poor prognosis of HCC patients.
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TL;DR: It is reported that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1,BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes.