Journal ArticleDOI
Cognitive phenotypes in Alzheimer's disease and genetic risk.
Julie S. Snowden,Cheryl L. Stopford,Camille L. Julien,Jennifer C. Thompson,Yvonne S Davidson,Linda Gibbons,Antonia L. Pritchard,Corinne Lendon,Anna Richardson,Anoop Varma,David Neary,David M. A. Mann +11 more
TLDR
The study examined the cognitive characteristics of 523 AD patients at the time of their presentation to a neurological dementia clinic and explored the relationship to family history and apolipoprotein E (APOE) genotype.About:
This article is published in Cortex.The article was published on 2007-01-01. It has received 227 citations till now. The article focuses on the topics: Age of onset & Amnesia.read more
Citations
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Journal ArticleDOI
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Bruno Dubois,Bruno Dubois,Howard Feldman,Claudia Jacova,Harald Hampel,Harald Hampel,José Luis Molinuevo,Kaj Blennow,Steven T. DeKosky,Serge Gauthier,Dennis J. Selkoe,Randall J. Bateman,Stefano F. Cappa,Sebastian J. Crutch,Sebastiaan Engelborghs,Giovanni B. Frisoni,Nick C. Fox,Douglas Galasko,Marie-Odile Habert,Gregory A. Jicha,Agneta Nordberg,Florence Pasquier,Gil D. Rabinovici,Philippe Robert,Christopher C. Rowe,Stephen Salloway,Marie Sarazin,Stéphane Epelbaum,Stéphane Epelbaum,Leonardo Cruz de Souza,Leonardo Cruz de Souza,Leonardo Cruz de Souza,Bruno Vellas,Pieter Jelle Visser,Lon S. Schneider,Yaakov Stern,Philip Scheltens,Jeffrey L. Cummings +37 more
TL;DR: It is proposed that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease.
Journal ArticleDOI
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
Julie S. Snowden,Sara Rollinson,Jennifer C. Thompson,Jennifer C. Thompson,Jennifer M. Harris,Jennifer M. Harris,Cheryl L. Stopford,Cheryl L. Stopford,Anna Richardson,Anna Richardson,Matthew Jones,Matthew Jones,Alexander Gerhard,Alexander Gerhard,Yvonne S Davidson,Andrew C Robinson,Linda Gibbons,Quan Hu,Daniel DuPlessis,David Neary,David Neary,David M. A. Mann,Stuart Pickering-Brown +22 more
TL;DR: Mutations in the C9ORF72 gene may be a major cause not only of frontotemporal dementia with motor neuron disease but also of late onset psychosis, and the behavioural characteristics of patients with C9 ORF72 mutations are qualitatively distinct.
Journal ArticleDOI
Linguistic Features Identify Alzheimer's Disease in Narrative Speech.
TL;DR: In this paper, a statistical factor analysis was used to identify individuals with Alzheimer's disease from short narrative samples elicited with a picture description task, and to uncover the salient linguistic factors.
Journal ArticleDOI
Posterior cortical atrophy
Sebastian J. Crutch,Manja Lehmann,Manja Lehmann,Jonathan M. Schott,Gil D. Rabinovici,Martin N. Rossor,Nick C. Fox +6 more
TL;DR: Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies.
Journal ArticleDOI
Consensus classification of posterior cortical atrophy
Sebastian J. Crutch,Jonathan M. Schott,Gil D. Rabinovici,Melissa E. Murray,Julie S. Snowden,Julie S. Snowden,Wiesje M. van der Flier,Bradford C. Dickerson,Rik Vandenberghe,Samrah Ahmed,Thomas H. Bak,Bradley F. Boeve,Christopher C Butler,Stefano F. Cappa,Mathieu Ceccaldi,Leonardo Cruz de Souza,Bruno Dubois,Olivier Felician,Douglas Galasko,Jonathan Graff-Radford,Neill R. Graff-Radford,Patrick R. Hof,Pierre Krolak-Salmon,Manja Lehmann,Manja Lehmann,Eloi Magnin,Mario F. Mendez,Peter J. Nestor,Chiadi U. Onyike,Victoria S. Pelak,Yolande A.L. Pijnenburg,Silvia Primativo,Martin N. Rossor,Natalie S. Ryan,Philip Scheltens,Timothy J. Shakespeare,Aida Suarez Gonzalez,David F. Tang-Wai,Keir X.X. Yong,Maria C. Carrillo,Nick C. Fox +40 more
TL;DR: A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Elizabeth H. Corder,Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,Gary W. Small,A. D. Roses,Jonathan L. Haines,Margaret A. Pericak-Vance +8 more
TL;DR: The APOE-epsilon 4 allele is associated with the common late onset familial and sporadic forms of Alzheimer9s disease (AD) in 42 families with late onset AD.
Journal ArticleDOI
Metabolic Reduction in the Posterior Cingulate Cortex in Very Early Alzheimer's Disease
TL;DR: The result suggests a functional importance for the posterior cingulate cortex in impairment of learning and memory, which is a feature of very early Alzheimer's disease.
Journal ArticleDOI
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Clifford R. Jack,Ronald C. Petersen,Yue Cheng Xu,Peter C. O'Brien,Glenn E. Smith,Robert J. Ivnik,Bradley F. Boeve,Stephen C. Waring,Eric G. Tangalos,Emre Kokmen +9 more
TL;DR: In older patients with MCI, hippocampal atrophy determined by premorbid MRI-based volume measurements is predictive of subsequent conversion to AD.
Journal ArticleDOI
Attention and executive deficits in Alzheimer's disease: A critical review
Richard J. Perry,John R. Hodges +1 more
TL;DR: The progress that has been made in the research on attentional and executive deficits in Alzheimer's disease is summarized and it appears that divided attention and aspects of selective attention, such as set-shifting and response selection, are particularly vulnerable while sustained attention is relatively preserved in the early stages.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more