Journal ArticleDOI
Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water.
Xiaoyan Du,Meiping Tian,Xiaoxue Wang,Jie Zhang,Jie Zhang,Qingyu Huang,Liangpo Liu,Heqing Shen +7 more
TLDR
In this article, the weaned male Sprague-Dawly (SD) rats were treated with arsenic trioxide via drinking water for 6 months, simulating real developmental exposure situation of children.About:
This article is published in Environmental Pollution.The article was published on 2018-03-01. It has received 44 citations till now. The article focuses on the topics: Arsenic trioxide & DNA methylation.read more
Citations
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Journal ArticleDOI
The Role of Reactive Oxygen Species in Arsenic Toxicity.
TL;DR: The pathways involved in arsenic-induced redox imbalance are detailed, as well as current studies on prophylaxis and treatment strategies using antioxidants.
Journal ArticleDOI
Arsenic-induced neurotoxicity: a mechanistic appraisal.
TL;DR: The epidemiological studies reporting on the effects of arsenic in intellectual and cognitive function during development as well as studies showing the correlation between arsenic exposure and altered cognition and mental health in adults are discussed.
Journal ArticleDOI
m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite.
Lulu Bai,Qianghu Tang,Zhen Zou,Pan Meng,Baijie Tu,Yinyin Xia,Shuqun Cheng,Lina Zhang,Kai Yang,Shaoyu Mu,Xuefeng Wang,Xia Qin,Bo Lv,Xianqing Cao,Qizhong Qin,Xuejun Jiang,Chengzhi Chen +16 more
TL;DR: It is demonstrated for the first time that arsenite remarkably increased m6A modification, and FTO possessed the ability to alleviate the deficits in dopaminergic neurotransmission in response to arsenite exposure, the first evidence that regulation of FTO may be considered as a novel strategy for the prevention of arsenite-associated neurological disorders.
Journal ArticleDOI
LncRNA H19-mediated M2 polarization of macrophages promotes myofibroblast differentiation in pulmonary fibrosis induced by arsenic exposure.
Tian Xiao,Zhonglan Zou,Junchao Xue,Binafsha Manzoor Syed,Jing Sun,Xiangyu Dai,Ming Shi,Junjie Li,Shaofeng Wei,Huanwen Tang,Aihua Zhang,Qizhan Liu +11 more
TL;DR: Results indicated that H19 functioned as an miRNA sponge for let-7a, which was involved in arsenite-induced M2 polarization of macrophages and induced the myofibroblast differentiation phenotype by regulation of c-Myc.
Journal ArticleDOI
Fluoxastrobin-induced effects on acute toxicity, development toxicity, oxidative stress, and DNA damage in Danio rerio embryos.
TL;DR: It is elucidated that FLUO inhibition of spinal and heart development may be induced by oxidative stress, and this investigation could be a reminder for people to be more judicious in SF-use to avoid or relieve SF toxicity to nontarget organisms.
References
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Journal ArticleDOI
Hazards of heavy metal contamination.
TL;DR: Recent data indicate that adverse health effects of cadmium exposure may occur at lower exposure levels than previously anticipated, primarily in the form of kidney damage but possibly also bone effects and fractures, and measures should be taken to reduce cadmiam exposure in the general population in order to minimize the risk of adverse health results.
Journal ArticleDOI
Morris water maze: procedures for assessing spatial and related forms of learning and memory
TL;DR: The Morris water maze has proven to be a robust and reliable test that is strongly correlated with hippocampal synaptic plasticity and NMDA receptor function and trial-dependent, latent and discrimination learning can be assessed using modifications of the basic protocol.
Journal ArticleDOI
Advances in metal-induced oxidative stress and human disease
Klaudia Jomová,Marian Valko +1 more
TL;DR: An overview of redox and non-redox metal-induced formation of free radicals and the role of oxidative stress in toxic action of metals is provided.
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Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
Shinichi Someya,Shinichi Someya,Wei Yu,William C. Hallows,Jinze Xu,James M. Vann,Christiaan Leeuwenburgh,Masaru Tanokura,John M. Denu,Tomas A. Prolla +9 more
TL;DR: These findings suggest that Sirt3-dependent mitochondrial adaptations may be a central mechanism of aging retardation in mammals and suggest that CR reduces oxidative DNA damage in multiple tissues and prevents AHL in wild-type mice but fails to modify these phenotypes in mice lacking the mitochondrial deacetylase Sirt 3.
Journal ArticleDOI
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
Jian Feng,Yu Zhou,Yu Zhou,Susan Campbell,Thuc Le,En Li,J. David Sweatt,Alcino J. Silva,Guoping Fan +8 more
TL;DR: Dnmt1 and Dnmt3a are required for synaptic plasticity, learning and memory through their overlapping roles in maintaining DNA methylation and modulating neuronal gene expression in adult CNS neurons.