COVID-19 Diagnostics: Past, Present, and Future
Alexis Scholtz,Anuradha Ramoji,Anja Silge,Jakob R. Jansson,Ian G. de Moura,Jürgen Popp,Jakub P. Sram,Andrea M. Armani +7 more
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TLDR
In this paper, the authors developed new testing strategies to accelerate the time-to-decision for SARS-CoV-2 detection and new spectroscopic methods were developed to accelerate time to decision.Abstract:
In winter of 2020, SARS-CoV-2 emerged as a global threat, impacting not only health but also financial and political stability. To address the societal need for monitoring the spread of SARS-CoV-2, many existing diagnostic technologies were quickly adapted to detect SARS-CoV-2 RNA and antigens as well as the immune response, and new testing strategies were developed to accelerate time-to-decision. In parallel, the infusion of research support accelerated the development of new spectroscopic methods. While these methods have significantly reduced the impact of SARS-CoV-2 on society when coupled with behavioral changes, they also lay the groundwork for a new generation of platform technologies. With several epidemics on the horizon, such as the rise of antibiotic-resistant bacteria, the ability to quickly pivot the target pathogen of this diagnostic toolset will continue to have an impact. ©read more
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Phototherapy and optical waveguides for the treatment of infection.
Dingbowen Wang,Michelle Laurel Kuzma,Xinyu Tan,Xinyu Tan,Tong-Chuan He,Cheng Dong,Zhiwen Liu,Jian Yang +7 more
TL;DR: In this article, a review outlines principles and applications of phototherapy and optical waveguides for infection control, as well as challenges and outlook regarding this delivery system are rigorously discussed in a hope to inspire future developments of optical waveguide-mediated phototherapy for the management of infection and beyond.
Journal ArticleDOI
Conventional and Novel Diagnostic Tools for the Diagnosis of Emerging SARS-CoV-2 Variants
Vivek P. Chavda,Disha Valu,Palak K. Parikh,Nikita Tiwari,Abu Sufiyan Chhipa,Somanshi Shukla,Snehal S. Patel,Pankti C. Balar,Ana Cláudia Paiva-Santos,Vandana B. Patravale +9 more
TL;DR: In this article , a review of available molecular diagnostic techniques and their pitfalls in detecting emerging VOCs of SARS-CoV-2, and lastly, we have discussed AI-ML- and nanotechnology-based smart diagnostic techniques for SARS CoV2 detection.
Journal ArticleDOI
Understanding viruses and viral infections by biophotonic methods
Anuradha Ramoji,Susanne Pahlow,Aikaterini Pistiki,Jan Rueger,Tanveer Ahmed Shaik,Haodong Shen,Christina Wichmann,Christoph Krafft,Jürgen Popp +8 more
TL;DR: This review systematically discusses different aspects of virions and how their properties and functions can be studied using different light‐based technologies, focusing on virion classification, detection and interactions with the host's immune system.
Journal ArticleDOI
Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy
Hamideh Salehi,Anuradha Ramoji,Said Mougari,Peggy Merida,Aymeric Neyret,Jürgen Popp,Branka Horvat,Delphine Muriaux,Frédéric Cuisinier +8 more
TL;DR: In this paper , the authors analyzed biochemical modifications due to SARS-CoV-2 infection in cells by confocal Raman microscopy and compared the results with the infection with another RNA virus, the measles virus.
Journal ArticleDOI
Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy.
Hamideh Salehi,Anuradha Ramoji,Said Mougari,Peggy Merida,Aymeric Neyret,Jürgen Popp,Branka Horvat,Delphine Muriaux,Frédéric Cuisinier +8 more
TL;DR: In this paper , the authors analyzed biochemical modifications due to SARS-CoV-2 infection in cells by confocal Raman microscopy and compared the results with the infection with another RNA virus, the measles virus.
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TL;DR: It is suggested that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset and may be helpful for the diagnosis of suspected patients with negative RT–PCR results and for the identification of asymptomatic infections.