Journal ArticleDOI
CRYSOL : a program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates
TLDR
In this paper, a program for evaluating the solution scattering from macromolecules with known atomic structure is presented, which uses multipole expansion for fast calculation of the spherically averaged scattering pattern and takes into account the hydration shell.Abstract:
A program for evaluating the solution scattering from macromolecules with known atomic structure is presented. The program uses multipole expansion for fast calculation of the spherically averaged scattering pattern and takes into account the hydration shell. Given the atomic coordinates (e.g. from the Brookhaven Protein Data Bank) it can either predict the solution scattering curve or fit the experimental scattering curve using only two free parameters, the average displaced solvent volume per atomic group and the contrast of the hydration layer. The program runs on IBM PCs and on the major UNIX platforms.read more
Citations
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Journal ArticleDOI
Structure of the complex between HER2 and an antibody paratope formed by side chains from tryptophan and serine.
Robert D. Fisher,Mark Ultsch,Andreas Lingel,Gabriele Schaefer,Lily Shao,Sara C. Birtalan,Sachdev S. Sidhu,Charles Eigenbrot +7 more
TL;DR: A paratope raised against the human ErbB family member HER2 is described, using a binary diversity tryptophan/serine library displayed on phage and containing an unprecedented trimeric arrangement of HER2 closely related to previously observed homodimers of the related epidermal growth factor receptor.
Journal ArticleDOI
A mechanism for histone chaperoning activity of nucleoplasmin: thermodynamic and structural models.
Stefka G. Taneva,Sonia Bañuelos,Jorge Falces,Igor Arregi,Arturo Muga,Petr V. Konarev,Petr V. Konarev,Dmitri I. Svergun,Dmitri I. Svergun,Adrián Velázquez-Campoy,María A. Urbaneja +10 more
TL;DR: In this article, solution structural models of full-length NP and NP complexes with the functionally distinct nucleosomal core and linker histones are presented for the first time, providing a picture of the physical interactions between the NPs with NP core and tail domains, and the analysis of the binding events, employing a site-specific cooperative model, reveals a negative cooperativity-based regulatory mechanism for the linkers histone/nucleosomal histone exchange.
Journal ArticleDOI
The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.
Tracy L Putoczki,Tracy L Putoczki,Renwick C. J. Dobson,Renwick C. J. Dobson,Michael D. W. Griffin +4 more
TL;DR: Comparisons show important differences between the two cytokines and it is suggested that IL-11 engages GP130 differently to IL-6, and these data offer insight into the binding interactions ofIL-11 with each of its receptors and the structural mechanisms underlying agonist and antagonist variants of the protein.
Journal ArticleDOI
Evolution of the Plant Reproduction Master Regulators LFY and the MADS Transcription Factors: The Role of Protein Structure in the Evolutionary Development of the Flower
Catarina S. Silva,S. Puranik,Adam Round,Adam Round,Martha Brennich,Agnès Jourdain,François Parcy,Véronique Hugouvieux,Chloe Zubieta +8 more
TL;DR: The impact of structural biology on the understanding of the complex evolutionary process leading to the development of the bisexual flower is discussed and structural techniques are becoming important tools in unraveling TF function.
Journal ArticleDOI
Large, dynamic, multi-protein complexes: a challenge for structural biology
Bartosz Różycki,Evzen Boura +1 more
TL;DR: This paper describes how representative structures of dynamic multi-protein complexes are obtained utilizing the EROS hybrid method that the authors have co-developed.
References
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Book
International tables for X-ray crystallography
Norman Fordyce McKerron Henry,Lonsdale, Kathleen, Dame,John S. Kasper,Caroline H. MacGillavry,Gerard D. Rieck,James A. Ibers,Walter C. Hamilton +6 more
Angular Momentum in Quantum Mechanics
TL;DR: In this paper, the angular momentum, one of the most fundamental quantities in all of quantum mechanics, is introduced and a concise introduction to its application in atomic, molecular, and nuclear physics is provided.
Book
Angular Momentum in Quantum Mechanics
TL;DR: In this article, the angular momentum, one of the most fundamental quantities in all of quantum mechanics, is introduced and a concise introduction to its application in atomic, molecular, and nuclear physics is provided.