Journal ArticleDOI
CRYSOL : a program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates
TLDR
In this paper, a program for evaluating the solution scattering from macromolecules with known atomic structure is presented, which uses multipole expansion for fast calculation of the spherically averaged scattering pattern and takes into account the hydration shell.Abstract:
A program for evaluating the solution scattering from macromolecules with known atomic structure is presented. The program uses multipole expansion for fast calculation of the spherically averaged scattering pattern and takes into account the hydration shell. Given the atomic coordinates (e.g. from the Brookhaven Protein Data Bank) it can either predict the solution scattering curve or fit the experimental scattering curve using only two free parameters, the average displaced solvent volume per atomic group and the contrast of the hydration layer. The program runs on IBM PCs and on the major UNIX platforms.read more
Citations
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Journal ArticleDOI
Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.
Beatriz Trastoy,Joseph V. Lomino,Brian G. Pierce,Lester G. Carter,Sebastian Günther,John P. Giddens,Greg A. Snyder,Thomas M. Weiss,Zhiping Weng,Lai-Xi Wang,Eric J. Sundberg +10 more
TL;DR: The three-dimensional structure of EndoS is determined and a molecular model depicting how EndoS engages antibodies with high specificity is presented, providing a roadmap for engineering EndoS variants with unique activities for clinical and biotechnological applications.
Journal ArticleDOI
The solution structure of the pentatricopeptide repeat protein PPR10 upon binding atpH RNA
Benjamin S. Gully,Nathan Cowieson,Will A. Stanley,Kate Shearston,Ian Small,Alice Barkan,Charles S. Bond +6 more
TL;DR: The results support prior evidence that PPR10 binds RNA as a monomer, and that it does so in a manner that is commensurate with a canonical and predictable RNA-binding mode across much of the RNA–protein interface.
Journal ArticleDOI
Architecture of the type IV coupling protein complex of Legionella pneumophila
Mi Jeong Kwak,J. Dongun Kim,Hyunmin Kim,Cheol-Hee Kim,James W. Bowman,Seong Hoon Kim,Keehyoung Joo,Jooyoung Lee,Kyeong Sik Jin,Yeon-Gil Kim,Nam Ki Lee,Jae U. Jung,Byung-Ha Oh +12 more
TL;DR: The architecture and functional dissection of the multiprotein T4CP complexes are demonstrated and important insights into their substrate recruitment and processing are provided.
Journal ArticleDOI
Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Atsushi Yamagata,Yuri Miyazaki,Yuri Miyazaki,Norihiko Yokoi,Norihiko Yokoi,Hideki Shigematsu,Yusuke Sato,Sakurako Goto-Ito,Asami Maeda,Teppei Goto,Makoto Sanbo,Masumi Hirabayashi,Masumi Hirabayashi,Mikako Shirouzu,Yuko Fukata,Yuko Fukata,Masaki Fukata,Masaki Fukata,Shuya Fukai +18 more
TL;DR: The notion that the LGI1–ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission is supported, which provides structural insights into epilepsy-causingLGI1 mutations and might facilitate the development of novel anti-epilepsy drugs.
Journal ArticleDOI
NMR Analysis of the Conformational Properties of the Trapped on-pathway Folding Intermediate of the Bacterial Immunity Protein Im7
Sara B.-M. Whittaker,Graham R. Spence,J. Günter Grossmann,Sheena E. Radford,Geoffrey R. Moore +4 more
TL;DR: Though much of the native-like secondary structure of Im7 is present in the variants, their hydrophobic cores remain relatively fluid, demonstrating that these proteins being conformationally dynamic.
References
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Book
International tables for X-ray crystallography
Norman Fordyce McKerron Henry,Lonsdale, Kathleen, Dame,John S. Kasper,Caroline H. MacGillavry,Gerard D. Rieck,James A. Ibers,Walter C. Hamilton +6 more
Angular Momentum in Quantum Mechanics
TL;DR: In this paper, the angular momentum, one of the most fundamental quantities in all of quantum mechanics, is introduced and a concise introduction to its application in atomic, molecular, and nuclear physics is provided.
Book
Angular Momentum in Quantum Mechanics
TL;DR: In this article, the angular momentum, one of the most fundamental quantities in all of quantum mechanics, is introduced and a concise introduction to its application in atomic, molecular, and nuclear physics is provided.