Cut stroke in half: Polypill for primary prevention in stroke
Michael Brainin,Valery L. Feigin,Sheila Cristina Ouriques Martins,Karl Matz,Jayanta Roy,Peter Sandercock,Yvonne Teuschl,Jaakko Tuomilehto,Jaakko Tuomilehto,Anita Wiseman +9 more
TLDR
In this article, a review summarizes the potential for polypill therapies for stroke prevention and suggests a combination of a large supporting population-wide program with a registry-based quality control is the most likely perspective.Abstract:
This review summarizes the potential for polypill therapies for stroke prevention. While a number of studies applying different approaches regarding polypill have been performed, none of them has had a focus on stroke as the main outcome. A combination pill containing drugs such as statins, diuretics, and other antihypertensives is currently available in various formats. Estimates focusing mostly on primary prevention show that using such a combination drug a reduction in the 5-year stroke incidence by 50% can be achieved - especially in low- and middle-income countries with a high prevalence of risk factors even among people at young ages. A combination of a large supporting population-wide program with a registry-based quality control is the most likely perspective and can be achieved within a reasonable time frame and potentially have significant influence in young stroke populations.read more
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Journal ArticleDOI
Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
Catherine O. Johnson,Minh Nguyen,Gregory A. Roth,Emma Nichols,Tahiya Alam,Degu Abate,Foad Abd-Allah,Ahmed Abdelalim,Haftom Niguse Abraha,Niveen M E Abu-Rmeileh,Oladimeji Adebayo,Abiodun M. Adeoye,Gina Agarwal,Sutapa Agrawal,Amani Nidhal Aichour,Ibtihel Aichour,Miloud Taki Eddine Aichour,Fares Alahdab,Raghib Ali,Nelson Alvis-Guzman,Nahla Anber,Mina Anjomshoa,Jalal Arabloo,Antonio Arauz,Johan Ärnlöv,Amit Arora,Ashish Awasthi,Maciej Banach,Miguel A Barboza,Suzanne Barker-Collo,Till Bärnighausen,Sanjay Basu,Abate Bekele Belachew,Yaschilal Muche Belayneh,Derrick A Bennett,Isabela M. Benseñor,Krittika Bhattacharyya,Belete Biadgo,Ali Bijani,Boris Bikbov,Muhammad Shahdaat Bin Sayeed,Zahid A Butt,Lucero Cahuana-Hurtado,Juan Jesus Carrero,Félix Carvalho,Carlos A Castañeda-Orjuela,Franz Castro,Ferrán Catalá-López,Yazan Chaiah,Peggy Pei-Chia Chiang,Jee-Young Jasmine Choi,Hanne Christensen,Dinh-Toi Chu,Monica Cortinovis,Albertino Damasceno,Lalit Dandona,Rakhi Dandona,Ahmad Daryani,Kairat Davletov,Barbora de Courten,Vanessa De la Cruz-Góngora,Meaza Girma Degefa,Samath D Dharmaratne,Daniel Diaz,Manisha Dubey,Eyasu Ejeta Duken,Dumessa Edessa,Matthias Endres,Emerito Jose A. Faraon,Farshad Farzadfar,Eduarda Fernandes,Florian Fischer,Luisa Sorio Flor,Morsaleh Ganji,Abadi Kahsu Gebre,Teklu Gebrehiwo Gebremichael,Birhanu Geta,Kebede Embaye Gezae,Paramjit Gill,Elena V. Gnedovskaya,Héctor Gómez-Dantés,Alessandra C. Goulart,Giuseppe Grosso,Yuming Guo,Rajeev Gupta,Arvin Haj-Mirzaian,Arya Haj-Mirzaian,Samer Hamidi,Graeme J. Hankey,Hamid Yimam Hassen,Simon I. Hay,Mohamed I Hegazy,Behnam Heidari,Nabeel Herial,Mohammad Ali Hosseini,Sorin Hostiuc,Seyed Sina Naghibi Irvani,Sheikh Mohammed Shariful Islam,Nader Jahanmehr,Mehdi Javanbakht,Ravi Prakash Jha,Jost B. Jonas,Jacek Jerzy Jozwiak,Mikk Jürisson,Amaha Kahsay,Rizwan Kalani,Yogeshwar Kalkonde,Teshome Abegaz Kamil,Tanuj Kanchan,André Karch,Narges Karimi,Hamidreza Karimi-Sari,Amir Kasaeian,Tesfaye Dessale Kassa,Hossein Kazemeini,Adane Teshome Kefale,Yousef Khader,Ibrahim A Khalil,Ejaz Ahmad Khan,Young-Ho Khang,Jagdish Khubchandani,Daniel Kim,Yun Jin Kim,Adnan Kisa,Mika Kivimäki,Ai Koyanagi,Rita K. Krishnamurthi,G Anil Kumar,Alessandra Lafranconi,Sarah Lewington,Shanshan Li,Warren D. Lo,Alan D. Lopez,Stefan Lorkowski,Paulo A. Lotufo,Mark T Mackay,Marek Majdan,Reza Majdzadeh,Azeem Majeed,Reza Malekzadeh,Navid Manafi,Mohammad Ali Mansournia,Man Mohan Mehndiratta,Varshil Mehta,Getnet Mengistu,Atte Meretoja,Tuomo J. Meretoja,Bartosz Miazgowski,Tomasz Miazgowski,Ted R. Miller,Erkin M. Mirrakhimov,Bahram Mohajer,Yousef Mohammad,Milad Mohammadoo-Khorasani,Shafiu Mohammed,Farnam Mohebi,Ali H. Mokdad,Yaser Mokhayeri,Ghobad Moradi,Lidia Morawska,Ilais Moreno Velásquez,Seyyed Meysam Mousavi,Oumer Sada S. Muhammed,Walter Muruet,Mehdi Naderi,Mohsen Naghavi,Gurudatta Naik,Bruno Ramos Nascimento,Ruxandra Irina Negoi,Cuong Tat Nguyen,Long Hoang Nguyen,Yirga Legesse Nirayo,Bo Norrving,Jean Jacques Noubiap,Richard Ofori-Asenso,Felix Akpojene Ogbo,Andrew T Olagunju,Tinuke O Olagunju,Mayowa O. Owolabi,Jeyaraj D Pandian,Shanti Patel,Norberto Perico,Michael A. Piradov,Suzanne Polinder,Maarten J. Postma,Hossein Poustchi,V Prakash,Mostafa Qorbani,Alireza Rafiei,Fakher Rahim,Kazem Rahimi,Vafa Rahimi-Movaghar,Mahfuzar Rahman,Muhammad Aziz Rahman,Cesar Reis,Giuseppe Remuzzi,Andre M. N. Renzaho,Stefano Ricci,Nicholas L S Roberts,Stephen R. Robinson,Leonardo Roever,Gholamreza Roshandel,Parisa Sabbagh,Hosein Safari,Saeed Safari,Saeid Safiri,Amirhossein Sahebkar,Saleh Salehi Zahabi,Abdallah M. Samy,Paola Santalucia,Itamar S. Santos,João Vasco Santos,Milena M Santric Milicevic,Benn Sartorius,Arundhati R. Sawant,Aletta E. Schutte,Sadaf G. Sepanlou,Azadeh Shafieesabet,Masood Ali Shaikh,Mehran Shams-Beyranvand,Aziz Sheikh,Kevin N. Sheth,Kenji Shibuya,Mika Shigematsu,Min-Jeong Shin,Ivy Shiue,Soraya Siabani,Badr Hasan Sobaih,Luciano A. Sposato,Ipsita Sutradhar,P. A. Sylaja,Cassandra Szoeke,Braden Te Ao,Mohamad-Hani Temsah,Omar Temsah,Amanda G. Thrift,Marcello Tonelli,Roman Topor-Madry,Bach Xuan Tran,Khanh Bao Tran,Thomas Truelsen,Afewerki Gebremeskel Tsadik,Irfan Ullah,Olalekan A. Uthman,Muthiah Vaduganathan,Pascual R. Valdez,Tommi Vasankari,Rajagopalan Vasanthan,Narayanaswamy Venketasubramanian,Kia Vosoughi,Giang Thu Vu,Yasir Waheed,Elisabete Weiderpass,Kidu Gidey Weldegwergs,Ronny Westerman,Charles D.A. Wolfe,Dawit Zewdu Wondafrash,Gelin Xu,Ali Yadollahpour,Tomohide Yamada,Hiroshi Yatsuya,Ebrahim M Yimer,Naohiro Yonemoto,Mahmoud Yousefifard,Chuanhua Yu,Zoubida Zaidi,Mohammad Zamani,Afshin Zarghi,Yunquan Zhang,Sanjay Zodpey,Valery L. Feigin,Theo Vos,Christopher J L Murray +272 more
TL;DR: The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016, indicating that the burden of stroke is likely to remain high.
Journal ArticleDOI
The global burden of neurological disorders: translating evidence into policy.
Valery L. Feigin,Theo Vos,Emma Nichols,Mayowa O. Owolabi,William M. Carroll,Martin Dichgans,Günther Deuschl,Priya Parmar,Michael Brainin,Christopher J L Murray +9 more
TL;DR: In the past 30 years, the absolute numbers of deaths and people with disabilities owing to neurological diseases have risen substantially, particularly in low-income and middle-income countries, and further increases are expected globally as a result of population growth and ageing.
Journal ArticleDOI
Priorities to reduce the burden of stroke in Latin American countries
Sheila Cristina Ouriques Martins,Claudio Sacks,Werner Hacke,Michael Brainin,Francisco de Assis Figueiredo,Octavio M. Pontes-Neto,Pablo M Lavados Germain,Pablo M Lavados Germain,Pablo M Lavados Germain,Maria F Marinho,Arnold Hoppe Wiegering,Arnold Hoppe Wiegering,Diana Vaca McGhie,Salvador Cruz-Flores,Sebastián F. Ameriso,Walter M Camargo Villareal,Juan Carlos Durán,José E Fogolin Passos,Raul G Nogueira,João José Freitas de Carvalho,Gisele Sampaio Silva,Carla H.C. Moro,Jamary Oliveira-Filho,Rubens José Gagliardi,Eduardo D Gomes de Sousa,Felipe Fagundes Soares,Katia de Pinho Campos,Paulo F Piza Teixeira,Ivete Pillo Gonçalves,Irving R Santos Carquin,Mário Muñoz Collazos,Germán Enrique Pérez Romero,Javier I Maldonado Figueredo,Miguel A Barboza,Miguel Á Celis López,Fernando Góngora-Rivera,Carlos Cantú-Brito,Nelson Novarro-Escudero,Miguel Á Velázquez Blanco,Carlos A Arbo Oze de Morvil,Gloria Meza Rojas,Alan Flores,Jorge Arturo Hancco-Saavedra,Vivian Pérez Jimenez,Carlos Abanto Argomedo,Liliana Rodriguez Kadota,Roberto Crosa,Daissy L Mora Cuervo,Ana C de Souza,Leonardo A Carbonera,Tony F Álvarez Guzmán,Nelson Maldonado,Norberto L. Cabral,Craig S. Anderson,Patrice Lindsay,Anselm Hennis,Valery L. Feigin +56 more
TL;DR: The meeting culminated with the adoption of the special Gramado Declaration, signed by all Ministerial officials who attended the meeting and an opportunity now exists to translate this Declaration into an action plan to reduce the burden of stroke.
Journal ArticleDOI
Primary stroke prevention worldwide: translating evidence into action.
Mayowa O. Owolabi,Amanda G. Thrift,Ajay Mahal,Marie Ishida,Sheila Cristina Ouriques Martins,Walter D. Johnson,Jeyaraj D Pandian,Foad Abd-Allah,Joseph Yaria,Hoang T Phan,Greg Roth,Seana L. Gall,Richard Beare,Thanh G. Phan,Thanh G. Phan,Robert Mikulik,Rufus Akinyemi,Bo Norrving,Michael Brainin,Valery L. Feigin +19 more
TL;DR: In this paper, the authors provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention.
Journal ArticleDOI
Lifetime risk of common neurological diseases in the elderly population.
Silvan Licher,Sirwan K.L. Darweesh,Frank J. Wolters,Lana Fani,Alis Heshmatollah,Unal Mutlu,Peter J. Koudstaal,Jan Heeringa,Maarten J.G. Leening,M. Kamran Ikram,M. Arfan Ikram +10 more
TL;DR: The call for prioritising the focus on preventive interventions at population level which could substantially reduce the burden of common neurological diseases in the ageing population is strengthened.
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