Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression
M. Ángeles Marqués-Torrejón,Eva Porlan,Ana Banito,Esther Gómez-Ibarlucea,Andrés J. López-Contreras,Oscar Fernandez-Capetillo,Anxo Vidal,Jesús Gil,Josema Torres,Isabel Fariñas +9 more
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TLDR
A function of p21 is identified in the direct regulation of the expression of pluripotency factor Sox2, a key regulator of the specification and maintenance of neural progenitors and a regulation of NSC expansion driven by a p21/Sox2/p53 axis.About:
This article is published in Cell Stem Cell.The article was published on 2013-01-03 and is currently open access. It has received 171 citations till now. The article focuses on the topics: Subependymal zone & Neurogenesis.read more
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Cdks, cyclins and CKIs: roles beyond cell cycle regulation
TL;DR: The latest revelations about Cdks, cyclins and CKIs are discussed with the goal of showcasing their functional diversity beyond cell cycle regulation and their impact on development and disease in mammals.
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The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate
TL;DR: Molecular and functional evidence linking Sox proteins with stem cell biology, cellular reprogramming, and disease with an emphasis on Sox2 is reviewed.
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Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche
Paolo Codega,Violeta Silva-Vargas,Alex Paul,Angel R. Maldonado-Soto,Annina M. DeLeo,Erika Pastrana,Fiona Doetsch +6 more
TL;DR: In this paper, GFAP(+)CD133(+) (quiescent neural stem cells [qNSCs]) and GFAP (+)CD 133(+)EGFR(+) [aNSC] were isolated from the adult ventricular-subventricular zone.
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Neurogenesis in the embryonic and adult brain: same regulators, different roles
Noelia Urbán,François Guillemot +1 more
TL;DR: This review will compare and contrast the functions of transcription factors (TFs) and other regulatory molecules in the embryonic brain and in adult neurogenic regions of the adult brain in the mouse, with a special focus on the hippocampal niche and on the regulation of the balance between quiescence and activation of adult NSCs in this region.
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Sox2, a key factor in the regulation of pluripotency and neural differentiation
Shuchen Zhang,Wei Cui +1 more
TL;DR: Recent findings concerning the involvement of Sox2 in pluripotency, somatic cell reprogramming and neural differentiation as well as the molecular mechanisms underlying these roles are reviewed.
References
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower,Michele Harvey,Betty L. Slagle,Mark J. McArthur,Charles A. Montgomery,Janet S. Butel,Allan Bradley +6 more
TL;DR: Observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours.
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Mechanisms and functional implications of adult neurogenesis.
TL;DR: The factors that regulate proliferation and fate determination of adult neural stem cells are discussed and the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease is addressed.
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ATM and related protein kinases: safeguarding genome integrity
TL;DR: Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers.
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Multipotent cell lineages in early mouse development depend on SOX2 function
Ariel A. Avilion,Silvia K. Nicolis,Larysa H. Pevny,Lidia Pérez,Nigel Vivian,Robin Lovell-Badge +5 more
TL;DR: The data suggest that maternal components could be involved in establishing early cell fate decisions and that a combinatorial code, requiring SOX2 and OCT4, specifies the first three lineages present at implantation.
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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Jirina Bartkova,Nousin Rezaei,Michalis Liontos,Panagiotis Karakaidos,Dimitris Kletsas,Natalia Issaeva,Leandros-Vassilios F. Vassiliou,Evangelos Kolettas,Katerina Niforou,Vassilis Zoumpourlis,Munenori Takaoka,Hiroshi Nakagawa,Frederic Tort,Kasper Fugger,Fredrik Johansson,Maxwell Sehested,Claus L. Andersen,Lars Dyrskjøt,Torben F. Ørntoft,Jiri Lukas,Christos Kittas,Thomas Helleday,Thomas Helleday,Thanos D. Halazonetis,Thanos D. Halazonetis,Jiri Bartek,Vassilis G. Gorgoulis +26 more
TL;DR: It is shown that oncogene-induced senescence is associated with signs of DNA replication stress, including prematurely terminated DNA replication forks and DNA double-strand breaks, and, together with apoptosis, provides a barrier to malignant progression.