CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.
Masayuki Uehara,Kenta Yashiro,Satoru Mamiya,Jinsuke Nishino,Pierre Chambon,Pascal Dollé,Yasuo Sakai +6 more
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TLDR
It is suggested that the activity of CYP 26A1 and CYP26C1 is required for correct A-P patterning and production of migratory cranial neural crest cells in the developing mammalian brain.About:
This article is published in Developmental Biology.The article was published on 2007-02-15 and is currently open access. It has received 137 citations till now. The article focuses on the topics: Cranial neural crest & Neural crest.read more
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Retinoic Acid Synthesis and Signaling during Early Organogenesis
TL;DR: Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells.
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Retinoic acid signalling during development
Muriel Rhinn,Pascal Dollé +1 more
TL;DR: An overview of the RA biosynthesis, degradation and signalling pathways is provided and the main functions of this molecule during embryogenesis are reviewed.
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Retinoic acid in development: towards an integrated view
Karen Niederreither,Pascal Dollé +1 more
TL;DR: Retinoic acid has complex and pleiotropic functions during vertebrate development and some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine.
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Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development
Maryline Minoux,Filippo M. Rijli +1 more
TL;DR: Recent work that has begun to shed light on the molecular mechanisms that govern the spatiotemporal patterning of NCC-derived skeletal structures are reviewed – advances that are central to understanding craniofacial development and its evolution.
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Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish
Jared V. Goldstone,Andrew G. McArthur,Akira Kubota,Juliano Zanette,Juliano Zanette,Thiago E.M. Parente,Thiago E.M. Parente,Maria Jonsson,Maria Jonsson,David R. Nelson,John J. Stegeman +10 more
TL;DR: It is revealed that the majority of zebrafish CYP genes are expressed in embryos, with waves of expression of different sets of genes over the course of development, which provides a foundation for the use ofZebrafish as a model in toxicological, pharmacological and chemical disease research.
References
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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression
Amparo Cano,Mirna Perez-Moreno,Isabel Rodrigo,Annamaria Locascio,Maria Blanco,Marta G. del Barrio,Francisco Portillo,M. Angela Nieto +7 more
TL;DR: It is shown that mouse Snail is a strong repressor of transcription of the E-cadherin gene, opening up new avenues for the design of specific anti-invasive drugs.
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Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
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Clinical importance of the cytochromes P450.
TL;DR: The human cytochrome P450 (CYP) superfamily comprises 57 genes that code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D(3) synthesis; retinoic acid hydroxylation; and those of still unknown function.
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Embryonic retinoic acid synthesis is essential for early mouse post-implantation development.
TL;DR: It is established that RA synthesized by the post-implantation mammalian embryo is an essential developmental hormone whose lack leads to early embryo death.
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Retinoids in Embryonal Development
Sharon A. Ross,Sharon A. Ross,Sharon A. Ross,Peter McCaffery,Peter McCaffery,Peter McCaffery,Ursula C. Dräger,Ursula C. Dräger,Ursula C. Dräger,Luigi M. De Luca,Luigi M. De Luca,Luigi M. De Luca +11 more
TL;DR: The key role of vitamin A in embryonal development is reviewed and special emphasis is given to the physiological action of retinoids, as evident from the retinoid ligand knockout models.