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Open AccessJournal ArticleDOI

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial

Joanne R Chalmers, +21 more
- 21 Mar 2020 - 
- Vol. 395, Iss: 10228, pp 962-972
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TLDR
It is shown that families with eczema, asthma, or allergic rhinitis should not use daily emollients to try and prevent Eczema in their newborn, and there is some evidence to suggest an increased risk of skin infections.
About: 
This article is published in The Lancet.The article was published on 2020-03-21 and is currently open access. It has received 146 citations till now. The article focuses on the topics: Diprobase & Atopic dermatitis.

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ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children

Andreas Wollenberg, +27 more
- 17 Nov 2020 - 
TL;DR: Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease that must take into account clinical and pathogenic variabilities, the patient’s age and also target flare prevention.
Journal ArticleDOI

Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial.

Håvard Ove Skjerven, +55 more
- 21 Mar 2020 - 
TL;DR: This study does not support the use of these interventions to prevent atopic dermatitis by 12 months of age in infants and suggests that food allergy results will be reported once all investigations at age 3 years are completed in 2020.
Journal ArticleDOI

Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?

Helen A. Brough, +13 more
- 01 Sep 2020 - 
TL;DR: An overview of the atopic march and immune mechanism underlying the sensitization and effector phase of food allergy is provided and experimental models and human data that support the concept of epicutaneous sensitization are presented, forming one half of the dual‐allergen exposure hypothesis.
Journal ArticleDOI

Food allergy: epidemiology, pathogenesis, diagnosis, prevention, and treatment.

Joao Pedro Lopes, +1 more
- 01 Oct 2020 - 
TL;DR: The first FDA-approved food allergy therapy has come to fruition with superb additional approaches under investigation, and the diagnostics pipeline shows imminent advances for predicting reactivity, threshold and severity.
Journal ArticleDOI

Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents.

Thomas A. Luger, +12 more
- 02 May 2021 - 
TL;DR: The role of the skin barrier in the initiation and maintenance of atopic dermatitis has been investigated in this article, showing that a compromised epidermal barrier predisposes the skin to increased permeability of these compounds.
References
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Journal ArticleDOI

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Simon I. Hay, +803 more
- 16 Sep 2017 - 
TL;DR: At a global level, DALYs and HALE continue to show improvements and the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning.
Journal ArticleDOI

Filaggrin Mutations Associated with Skin and Allergic Diseases

Alan D. Irvine, +3 more
- 05 Oct 2011 - 
TL;DR: The biology of this molecule and the role of mutations in its altered function offer new insights into a range of conditions not previously thought to be related to one another.
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The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation

Hywel C Williams, +3 more
- 01 Sep 1994 - 
TL;DR: These two independent validation studies suggest that the newly proposed criteria for atopic dermatitis perform reasonably well in hospital out‐patient patients and further validation in community settings and in developing countries is needed.
Journal ArticleDOI

Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three

Joseph Odhiambo, +4 more
- 01 Dec 2009 - 
TL;DR: ISAAC Phase Three provides comprehensive global data on the prevalence of Eczema symptoms that is essential for public health planning and reveals that eczema is a disease of developing as well as developed countries.
Journal ArticleDOI

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.

Aileen Sandilands, +25 more
- 08 Apr 2007 - 
TL;DR: It is shown that the common filaggrin (FLG) null mutations that cause ichthyosis vulgaris and predispose to eczema and secondary allergic diseases are ancestral variants carried on conserved haplotypes, and a strategy for full sequencing of this large, highly repetitive gene is reported.
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Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Eric L. Simpson, +9 more
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Application of moisturizer to neonates prevents development of atopic dermatitis

Kenta Horimukai, +25 more
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Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy

Graham Roberts, +12 more
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Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants

Michael R. Perkin, +11 more
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Filaggrin Mutations Associated with Skin and Allergic Diseases

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