C
Cilla Söderhäll
Researcher at Karolinska Institutet
Publications - 131
Citations - 6957
Cilla Söderhäll is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Population & Asthma. The author has an hindex of 36, co-authored 114 publications receiving 5508 citations. Previous affiliations of Cilla Söderhäll include Karolinska University Hospital & Max Delbrück Center for Molecular Medicine.
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Journal ArticleDOI
Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility
Lovisa E. Reinius,Nathalie Acevedo,Maaike Joerink,Göran Pershagen,Sven-Erik Dahlén,Dario Greco,Cilla Söderhäll,Annika Scheynius,Juha Kere,Juha Kere,Juha Kere +10 more
TL;DR: In healthy male blood donors there is important variation in the methylation profiles of whole blood, mononuclear cells, granulocytes, and cells from seven selected purified lineages, indicating that whole blood methylation results might be unintelligible.
Journal ArticleDOI
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Bonnie R. Joubert,Janine F. Felix,Paul Yousefi,Kelly M. Bakulski,Allan C. Just,Carrie V. Breton,Sarah E. Reese,Christina A. Markunas,Christina A. Markunas,Rebecca C Richmond,Cheng-Jian Xu,Leanne K. Küpers,Sam S. Oh,Cathrine Hoyo,Olena Gruzieva,Cilla Söderhäll,Lucas A. Salas,Nour Baïz,Hongmei Zhang,Johanna Lepeule,Carlos Ruiz,Symen Ligthart,Tianyuan Wang,Jack A. Taylor,Liesbeth Duijts,Gemma C Sharp,Soesma A Jankipersadsing,Roy Miodini Nilsen,Ahmad Vaez,Ahmad Vaez,M. Daniele Fallin,Donglei Hu,Augusto A. Litonjua,Bernard F. Fuemmeler,Karen Huen,Juha Kere,Inger Kull,Monica Cheng Munthe-Kaas,Ulrike Gehring,Mariona Bustamante,Marie José Saurel-Coubizolles,Bilal M. Quraishi,Jie Ren,Jörg Tost,Juan R. González,Marjolein J. Peters,Siri E. Håberg,Zongli Xu,Joyce B. J. van Meurs,Tom R. Gaunt,Marjan Kerkhof,Eva Corpeleijn,Andrew P. Feinberg,Celeste Eng,Andrea A. Baccarelli,Sara E. Benjamin Neelon,Asa Bradman,Simon Kebede Merid,Anna Bergström,Zdenko Herceg,Hector Hernandez-Vargas,Bert Brunekreef,Mariona Pinart,Barbara Heude,Susan Ewart,Jin Yao,Nathanaël Lemonnier,Oscar H. Franco,Michael C. Wu,Albert Hofman,Albert Hofman,Wendy L. McArdle,Pieter van der Vlies,Fahimeh Falahi,Matthew W. Gillman,Lisa F. Barcellos,Ashok Kumar,Ashok Kumar,Ashok Kumar,Magnus Wickman,Magnus Wickman,Stefano Guerra,Marie-Aline Charles,John W. Holloway,Charles Auffray,Henning Tiemeier,George Davey Smith,Dirkje S. Postma,Marie-France Hivert,Brenda Eskenazi,Martine Vrijheid,Hasan Arshad,Josep M. Antó,Abbas Dehghan,Wilfried Karmaus,Isabella Annesi-Maesano,Jordi Sunyer,Akram Ghantous,Göran Pershagen,Nina Holland,Susan K. Murphy,Dawn L. DeMeo,Esteban G. Burchard,Christine Ladd-Acosta,Harold Snieder,Wenche Nystad,Gerard H. Koppelman,Caroline L Relton,Vincent W. V. Jaddoe,Allen J. Wilcox,Erik Melén,Erik Melén,Stephanie J. London +112 more
TL;DR: This large scale meta-analysis of methylation data identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
Journal ArticleDOI
MMP12, lung function, and COPD in high-risk populations.
Gary M. Hunninghake,Michael H. Cho,Yohannes Tesfaigzi,Manuel E. Soto-Quiros,Lydiana Avila,Jessica Lasky-Su,Chris Stidley,Erik Melén,Cilla Söderhäll,Jenny Hallberg,Inger Kull,Juha Kere,Magnus Svartengren,Göran Pershagen,Magnus Wickman,Christoph Lange,Dawn L. DeMeo,Craig P. Hersh,Barbara J. Klanderman,Benjamin A. Raby,David Sparrow,Steven D. Shapiro,Edwin K. Silverman,Augusto A. Litonjua,Scott T. Weiss,Juan C. Celedón +25 more
TL;DR: The minor allele of a SNP in MMP12 (rs2276109) is associated with a positive effect on lung function in children with asthma and in adults who smoke and is also associated withA reduced risk of COPD in adult smokers.
Journal ArticleDOI
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
Lavinia Paternoster,Marie Standl,Chih-Mei Chen,Adaikalavan Ramasamy,Klaus Bønnelykke,Liesbeth Duijts,Manuel A. R. Ferreira,Alexessander Couto Alves,Jacob P. Thyssen,Eva Albrecht,Hansjoerg Baurecht,Hansjoerg Baurecht,Bjarke Feenstra,Patrick M. A. Sleiman,Pirro G. Hysi,Nicole M. Warrington,Ivan Curjuric,Ronny Myhre,John A. Curtin,Maria M. Groen-Blokhuis,Marjan Kerkhof,Annika Sääf,Andre Franke,David Ellinghaus,Regina Foelster-Holst,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Stephen B. Montgomery,Stephen B. Montgomery,Holger Prokisch,Katharina Heim,Anna-Liisa Hartikainen,Anneli Pouta,Juha Pekkanen,Alexandra I. F. Blakemore,Jessica L. Buxton,Marika Kaakinen,David L. Duffy,Pamela A. F. Madden,Andrew C. Heath,Grant W. Montgomery,Philip J. Thompson,Melanie C. Matheson,Peter N. Le Souëf,Beate St Pourcain,George Davey Smith,John Henderson,John P. Kemp,Nicholas J. Timpson,Panos Deloukas,Susan M. Ring,H-Erich Wichmann,Martina Mueller-Nurasyid,Natalija Novak,Norman Klopp,Elke Rodriguez,Wendy L. McArdle,Allan Linneberg,Torkil Menné,Ellen A. Nohr,Albert Hofman,André G. Uitterlinden,Cornelia M. van Duijin,Fernando Rivadeneira,Johan C. de Jongste,Ralf J. P. van der Valk,Matthias Wjst,Rain Jögi,Frank Geller,Heather A. Boyd,Jeff Murray,Cecilia Kim,Frank D. Mentch,Michael E. March,Massimo Mangino,Tim D. Spector,Veronique Bataille,Craig E. Pennell,Patrick G. Holt,Peter D. Sly,Carla M. T. Tiesler,Elisabeth Thiering,Thomas Illig,Medea Imboden,Medea Imboden,Wenche Nystad,Angela Simpson,Jouke-Jan Hottenga,Dirkje S. Postma,Gerard H. Koppelman,Henriette A. Smit,Cilla Söderhäll,Bo L. Chawes,Eskil Kreiner-Møller,Hans Bisgaard,Erik Melén,Erik Melén,Dorret I. Boomsma,Adnan Custovic,Bo Jacobsson,Bo Jacobsson,Nicole Probst-Hensch,Nicole Probst-Hensch,Lyle J. Palmer,Daniel Glass,Hakon Hakonarson,Hakon Hakonarson,Mads Melbye,Deborah Jarvis,Vincent W. V. Jaddoe,Christian Gieger,David P. Strachan,Nicholas G. Martin,Marjo-Riitta Järvelin,Joachim Heinrich,David M. Evans,Stephan Weidinger +116 more
TL;DR: A genome-wide association meta-analysis of affected individuals and controls and the ten most strongly associated new susceptibility loci examined underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
Lavinia Paternoster,Marie Standl,Chih-Mei Chen,Adaikalavan Ramasamy,Klaus Bønnelykke,Liesbeth Duijts,Manuel A. R. Ferreira,Alexessander Couto Alves,Jacob P. Thyssen,Eva Albrecht,Hansjoerg Baurecht,Hansjoerg Baurecht,Bjarke Feenstra,Patrick M. A. Sleiman,Pirro G. Hysi,Nicole M. Warrington,Ivan Curjuric,Ronny Myhre,John A. Curtin,Maria M. Groen-Blokhuis,Marjan Kerkhof,Annika Sääf,Andre Franke,David Ellinghaus,Regina Foelster-Holst,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Stephen B. Montgomery,Stephen B. Montgomery,Holger Prokisch,Katharina Heim,Anna-Liisa Hartikainen,Anneli Pouta,Juha Pekkanen,Alexandra I. F. Blakemore,Jessica L. Buxton,Marika Kaakinen,David L. Duffy,Pamela A. F. Madden,Andrew C. Heath,Grant W. Montgomery,Philip J. Thompson,Melanie C. Matheson,Peter N. Le Souëf,Beate St Pourcain,George Davey Smith,John Henderson,John P. Kemp,Nicholas J. Timpson,Panos Deloukas,Susan M. Ring,H-Erich Wichmann,Martina Mueller-Nurasyid,Natalija Novak,Norman Klopp,Elke Rodriguez,Wendy L. McArdle,Allan Linneberg,Torkil Menné,Ellen A. Nohr,Albert Hofman,André G. Uitterlinden,Cornelia M. van Duijin,Fernando Rivadeneira,Johan C. de Jongste,Ralf J. P. van der Valk,Matthias Wjst,Rain Jögi,Frank Geller,Heather A. Boyd,Jeff Murray,Cecilia Kim,Frank D. Mentch,Michael E. March,Massimo Mangino,Tim D. Spector,Veronique Bataille,Craig E. Pennell,Patrick G. Holt,Peter D. Sly,Carla M. T. Tiesler,Elisabeth Thiering,Thomas Illig,Medea Imboden,Medea Imboden,Wenche Nystad,Angela Simpson,Jouke-Jan Hottenga,Dirkje S. Postma,Gerard H. Koppelman,Henriette A. Smit,Cilla Söderhäll,Bo L. Chawes,Eskil Kreiner-Møller,Hans Bisgaard,Erik Melén,Erik Melén,Dorret I. Boomsma,Adnan Custovic,Bo Jacobsson,Bo Jacobsson,Nicole Probst-Hensch,Nicole Probst-Hensch,Lyle J. Palmer,Daniel Glass,Hakon Hakonarson,Hakon Hakonarson,Mads Melbye,Deborah Jarvis,Vincent W. V. Jaddoe,Christian Gieger,David P. Strachan,Nicholas G. Martin,Marjo-Riitta Järvelin,Joachim Heinrich,David M. Evans,Stephan Weidinger +116 more
TL;DR: This paper conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals from 14 studies.