DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
Christopher J. Yuskaitis,Jinita B Modasia,Sandra Schrötter,Leigh-Ana Rossitto,Karenna J. Groff,Christopher Morici,Divakar S. Mithal,Ram Prosad Chakrabarty,Navdeep S. Chandel,Brendan D. Manning,Mustafa Sahin +10 more
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TLDR
In this paper , the brain mTORC1 signaling is reduced after acute fasting of mice and that neuronal mTORc1 integrates GATOR1 complex-mediated amino acid and tuberous sclerosis complex (TSC)-mediated growth factor signaling.About:
This article is published in Cell Reports.The article was published on 2022-08-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Medicine & mTORC1.read more
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Intermittent fasting interventions to leverage metabolic and circadian mechanisms for cancer treatment and supportive care outcomes.
Faiza Kalam,Dara James,Yun Li,Michael P. Coleman,Violet A. Kiesel,Elizabeth M. Cespedes Feliciano,Stephen D. Hursting,Dorothy D. Sears,Amber S. Kleckner +8 more
TL;DR: In this article , the metabolic and circadian rhythm mechanisms underlying the proposed benefits of intermittent fasting for the cancer population are described, and the authors summarize epidemiological, preclinical, and clinical studies in cancer published between January 2020 and August 2022 and propose avenues for future research.
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The Effects of Dietary Interventions on Brain Aging and Neurological Diseases
TL;DR: In this paper , the effects of intermittent and periodic fasting on improving phenotypic outcomes, such as cognitive and motor-coordination decline, in the normal aging brain through an increase in neurogenesis and synaptic plasticity, and decrease in neuroinflammation, mitochondrial dysfunction and oxidative stress.
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Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease
Lu Liu,Jing Xu,Zhiyu Zhang,Dongwen Ren,Yuzheng Wu,Dan Wang,Yi Zhang,Shuwu Zhao,Qian Chen,Tao Wang +9 more
TL;DR: In this paper , an optimized protein diet strategy with concomitant management of AA homeostasis was proposed to reduce the risks of diabetic kidney disease in a setting of hyperglycemia.
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Tetrastigma hemsleyanum suppresses neuroinflammation in febrile seizures rats via regulating PKC-δ/caspase-1 signaling pathway.
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Watch Out for GATORs: Fasting, Seizures, and Nutrient Sensing
TL;DR: In this article , the authors proposed a method to solve the problem of the problem: this article ] of unstructured data.[Box: see text] [2] .
References
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Yasemin Sancak,Liron Bar-Peled,Roberto Zoncu,Andrew L. Markhard,Shigeyuki Nada,David M. Sabatini +5 more
TL;DR: It is shown that amino acids induce the movement of m TORC1 to lysosomal membranes, where the Rag proteins reside, and Rag-Ragulator-mediated translocation of mTORC1 is the key event in amino acid signaling to mtorC1.
Journal ArticleDOI
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Paul Nicklin,Philip Bergman,Bailin Zhang,Ellen Triantafellow,Henry Wang,Beat Nyfeler,Haidi Yang,Marc Hild,Charles Kung,Christine D. Wilson,Vic E. Myer,Jeffrey P. MacKeigan,Jeffrey A. Porter,Y. Karen Wang,Lewis C. Cantley,Peter Finan,Leon Murphy +16 more
TL;DR: It is shown that cellular uptake of L-glutamine and its subsequent rapid efflux in the presence of essential amino acids (EAA) is the rate-limiting step that activates mTOR.
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Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
Kenta Hara,Kazuyoshi Yonezawa,Qing-Ping Weng,Mark T. Kozlowski,Christopher Belham,Joseph Avruch +5 more
TL;DR: The present study identifies the operation of a signal tranduction pathway in mammalian cells that provides a checkpoint control, linking amino acid sufficiency to the control of peptide chain initiation, indicating that mTOR is required for the response to amino acids.
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mTOR at the nexus of nutrition, growth, ageing and disease
Grace Y. Liu,David M. Sabatini +1 more
TL;DR: This Review highlights recent advances in the understanding of the complex regulation of the mTOR pathway and discusses its function in the context of physiology, human disease and pharmacological intervention.
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Sestrin2 is a leucine sensor for the mTORC1 pathway
Rachel L. Wolfson,Lynne Chantranupong,Robert A. Saxton,Kuang Shen,Sonia M. Scaria,Jason R. Cantor,David M. Sabatini +6 more
TL;DR: In this paper, it was shown that leucine, but not arginine, disrupts the Sestrin2-GATOR2 interaction with a dissociation constant of 20 micromolar.