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Open AccessJournal ArticleDOI

Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

Ginger Lehrman, +12 more
- 13 Aug 2005 - 
- Vol. 366, Iss: 9485, pp 549-555
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TLDR
In this article, the ability of the histone deacetylase 1 (HDAC) inhibitor valproic acid to deplete persistent, latent infection in resting CD4+ T cells was evaluated.
About: 
This article is published in The Lancet.The article was published on 2005-08-13 and is currently open access. It has received 499 citations till now. The article focuses on the topics: Enfuvirtide.

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The many roles of histone deacetylases in development and physiology: Implications for disease and therapy

Michael Haberland, +2 more
- 01 Jan 2009 - 
TL;DR: In this article, the expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programs of gene expression.
Journal ArticleDOI

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

Ya Chi Ho, +10 more
- 24 Oct 2013 - 
TL;DR: The identification of replication-competent noninduced proviruses indicates that the size of the latent reservoir-and, hence, the barrier to cure-may be up to 60-fold greater than previously estimated.
Journal ArticleDOI

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

Nancie M. Archin, +16 more
- 26 Jul 2012 - 
TL;DR: It is demonstrated that a molecular mechanism known to enforce HIV latency can be therapeutically targeted in humans, provides proof-of-concept for histone deacetylase inhibitors as a therapeutic class, and defines a precise approach to test novel strategies to attack and eradicate latent HIV infection directly.
Journal ArticleDOI

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

Liang Shan, +10 more
- 23 Mar 2012 - 
TL;DR: It is shown that after reversal of latency in an in vitro model, infected resting CD4(+) T cells survived despite viral cytopathic effects, even in the presence of autologous cytolytic T lymphocytes from most patients on HAART, demonstrating that stimulating HIV-1-specific CTLs prior to reactivating latent HIV- 1 may be essential for successful eradication efforts.
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HIV/AIDS epidemiology, pathogenesis, prevention, and treatment

Viviana Simon, +3 more
- 05 Aug 2006 - 
TL;DR: This Seminar provides an update on epidemiology, pathogenesis, treatment, and prevention interventions pertinent to HIV-1.
References
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Book

Generalized Linear Models

Peter McCullagh, +1 more
TL;DR: In this paper, a generalization of the analysis of variance is given for these models using log- likelihoods, illustrated by examples relating to four distributions; the Normal, Binomial (probit analysis, etc.), Poisson (contingency tables), and gamma (variance components).
Book

Generalized Linear Models

John H. Schuenemeyer, +2 more
Journal ArticleDOI

Generalized linear models. 2nd ed.

Peter McCullagh, +1 more
- 01 Jun 1993 - 
TL;DR: A class of statistical models that generalizes classical linear models-extending them to include many other models useful in statistical analysis, of particular interest for statisticians in medicine, biology, agriculture, social science, and engineering.
Journal ArticleDOI

Generalized Linear Models

P. J. Cheek
- 01 Nov 1990 - 
TL;DR: Generalized linear models, 2nd edn By P McCullagh and J A Nelder as mentioned in this paper, 2nd edition, New York: Manning and Hall, 1989 xx + 512 pp £30
Journal ArticleDOI

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

Diana Finzi, +14 more
- 14 Nov 1997 - 
TL;DR: In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from resting CD4+ T lymphocytes, and generally did not show mutations associated with resistance to the relevant antiretroviral drugs.
Related Papers (5)

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

Diana Finzi, +14 more
- 14 Nov 1997 - 

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

Janet D. Siliciano, +9 more
- 01 Jun 2003 - 

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

Tae Wook Chun, +15 more
- 08 May 1997 - 

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

Nancie M. Archin, +16 more
- 26 Jul 2012 - 

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

Tae-Wook Chun, +8 more
- 25 Nov 1997 -